This medication is used to treat ovarian cancer. It is a chemotherapy drug that works by slowing the growth of cancer cells. It may also be used for other conditions as determined by your doctor. Lynparza (Olaparib) is a PARP enzyme inhibitor. It works by killing certain cancer cells.
Lynparza (Olaparib) is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, including PARP1, PARP2, and PARP3. PARP enzymes are involved in normal cellular homeostasis, such as DNA transcription, cell cycle regulation, and DNA repair. Lynparza (Olaparib) has been shown to inhibit growth of select tumor cell lines in vitro and decrease tumor growth in mouse xenograft models of human cancer both as monotherapy or following platinum-based chemotherapy. Increased cytotoxicity and anti-tumor activity following treatment with Lynparza (Olaparib) were noted in cell lines and mouse tumor models with deficiencies in BRCA. In vitro studies have shown that Lynparza (Olaparib)-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complex, resulting in disruption of cellular homeostasis and cell death.
Nausea, vomiting, loss of appetite, diarrhea, constipation, bad taste in your mouth, dizziness, or joint/back/muscle pain may occur. Rarely, nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals or limiting activity may help lessen nausea and vomiting. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Store Lynparza (Olaparib) at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Avoid temperatures higher than 104 degrees F (40 degrees C). Do not take Lynparza (Olaparib) if it has been at a temperature higher than 104 degrees F (40 degrees C). Keep Lynparza (Olaparib) out of the reach of children and away from pets.
Before starting Lynparza (Olaparib) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
Do not receive any kind of immunization or vaccination without your doctor's approval while taking Lynparza (Olaparib).
Lynparza (Olaparib) is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.