Brand name : Pomacel
Active ingredient : Pomalidomide
Manufactured : Glenmark Pharma
Strength : 2mg
Pack : 21 capsules in a container
Category : Anti-neoplastic drug


Pomacel 2mg is a Glenmark Pharmaceuticals product which is endorsed by FDA, containing an active anti-cancer drug called Pomalidomide.
Pomacel 2mg is available as orally bioavailable thalidomide derivative with various therapeutic activities such as;
Immuno modulatory
Pomacel 2mg is like thalidomide & Lenalidomide with related to decreased rate of serum aminotransferase elevations during treatment. This may lead to severe liver injury.
Pomacel 2mg is involved in the treatment for regression & unmanageable multiple myeloma.
Pomacel 2mg is used in the patients who are failing to response for Lenalidomide treatment.
Pomacel 2mg is used in combination with dexamethasone.


The major therapeutic indication of Pomacel 2mg is involved in the treatment of multiple myeloma. This treatment is occurred by combining with dexamethasone for reducing the side effect associated with Pomacel 2mgomide.
Pomacel 2mg is majorly indicated in patients who are not reacts for prior two therapies like Lenalidomide & proteasome inhibitor.


The prescribed dose of Pomacelin multiple myeloma is 4mg should be administered orally as once a day on day 1 to 21 of reciprocated 28-day cycles.
Pomacel 2mg should be concomitant with dexamethasone.
Pomacel 2mg Capsules should be taken with or without food.
During hematological toxicities:
ANC (absolute neutrophils count) <500/mcl: Postpone the Pomaceltherapy and provide CBC weekly
ANC more than or equal to 500/mcl: Continue the Pomacel3mg daily.
Platelets count <25,000/mcL: postpone the Pomaceltreatment & follow the CBC
>50,000/mcL: continue 3mg of Pomacel
Pomacel 2mg with potent CYP1A2 inhibitor:
During this combination reduce the dose of Pomacelby 50%
In renal impairment:
Initial dose of Pomacel is 3mg
In hepatic impairment:
Mild to moderate condition, an initial dose of Pomacelis 3mg; in severe condition, the initial dose of Pomacel is 2mg.


Pomacel 2mg exhibits various activities like;
Anti-neoplastic activity:
Prohibits proliferation
Promote apoptosis of hematopoietic cancer cells
Co adjuvant with dexamethasone in both Lenalidomide sensitive & resistant myeloma cells to activate the tumor cell apoptosis
Immuno modulatory:
Boosted the T-cells & natural killer cell mediate immunity.
The drug is prohibited the formation of pro-inflammatory cytokines by monocytes.
Interfere with formation of new vessels and leads to inhibit the cell division.


There are two major worsening condition may occur during the treatment using with Pomacel 2mg.
Embryo fetal damage :
Pomacel 2mg Capsules are contraindicated to pregnancy period.
During the treatment, patients avoid to becoming pregnant.
Use effective contraceptives for preventing pregnancy during therapy.
Venous & arterial thromboembolism:
Patient who are receiving Pomacel 2mg Capsules have chance of getting deep vein thrombosis, pulmonary embolism, myocardial infarction & stroke.
This type of condition should be treated by initiating prophylactic anti-thrombotic drugs.
The patients who are acquiring this condition then thromboprophylaxis should be provided


Pomalidomide metabolism is mediated by CYP1A2 & CYP3A4.
The concomitant use of Pomacel 2mg with CYP1A2 drugs like Fluvoxamine causes elevation of Cmax& AUC of Pomalidomide and concludes as increased concentration of Pomacelleads to higher extent of adverse effects associated with Pomalid
In this condition, reduce the dose of Pomacel 2mg and recommended.


Pomacel 2mg should be contraindicated to pregnancy & lactating women. The pregnancy category of Pomacel 2mg is X.


More common effects of Pomacel 2mg :
If taken during pregnancy, Severe life-threatening human birth defects
Low white blood cell count
Shortness of breath
Upper respiratory infections
Back pain
Less common effects of Pomacel 2mg

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