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Pomired - 2mg

drug

PRODUCT DETAILS

Brand name : Pomired
Active ingredient : Pomalidomide
Manufactured : Dr. Reddy’s
Strength : 2mg
Pack : 21 capsules in a container
Category : Anti-neoplastic drug

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Pomired 2mg is a product which is endorsed by FDA, containing an active anti-cancer drug called Pomalidomide.
Pomired 2mg is available as orally bioavailable thalidomide derivative with various therapeutic activities such as;
Immuno modulatory
Anti-angiogenesis
Anti-neoplastic
Pomired 2mg is like thalidomide & Lenalidomide with related to decreased rate of serum aminotransferase elevations during treatment.
This may lead to severe liver injury.
Pomired 2mg is involved in the treatment for regression & unmanageable multiple myeloma.
Pomired 2mg is used in the patients who are failing to response for Lenalidomide treatment.
Pomired 2mg is used in combination with dexamethasone.

INDICATION

The major therapeutic indication of Pomired 2mg is involved in the treatment of multiple myeloma.
This treatment is occurred by combining with dexamethasone for reducing the side effect associated with Pomired 2mgomide.
Pomired 2mg is majorly indicated in patients who are not reacts for prior two therapies like Lenalidomide & proteasome inhibitor.

DOSAGE & ADMINISTRATION

The prescribed dose of Pomired in multiple myeloma is 4mg should be administered orally as once a day on day 1 to 21 of reciprocated 28-day cycles.
Pomired 2mg should be concomitant with dexamethasone.
Pomired 2mg capsules should be taken with or without food.
During hematological toxicities;
Neutropenia;
ANC (absolute neutrophils count) <500/mcl: Postpone the Pomired therapy and provide CBC weekly
ANC more than or equal to 500/mcl: Continue the Pomired3mg daily.
Thrombocytopenia:
Platelets count <25,000/mcL: postpone the Pomired treatment & follow the CBC
>50,000/mcL: continue 3mg of Pomired
Pomired 2mg with potent CYP1A2 inhibitor:
During this combination reduce the dose of Pomired by 50%
In renal impairment:
Initial dose of Pomired is 3mg
In hepatic impairment:
Mild to moderate condition, an initial dose of Pomired is 3mg; in severe condition, the initial dose of Pomired is 2mg.

WORK AS

Pomired 2mg exhibits various activities like :
Anti-neoplastic activity:
Prohibits proliferation
Promote apoptosis of hematopoietic cancer cells
Co adjuvant with dexamethasone in both Lenalidomide sensitive & resistant myeloma cells to activate the tumor cell apoptosis
Immuno modulatory:
Boosted the T-cells & natural killer cell mediate immunity.
The drug is prohibited the formation of pro-inflammatory cytokines by monocytes.
Anti-angiogenesis:
Interfere with formation of new vessels and leads to inhibit the cell division.

WARNING

There are two major worsening condition may occur during the treatment using with Pomired 2mg.
Embryo fetal damage :
Pomired 2mg capsules are contraindicated to pregnancy period.
During the treatment, patients avoid to becoming pregnant.
Use effective contraceptives for preventing pregnancy during therapy.
Venous & arterial thromboembolism :
Patient who are receiving Pomired 2mg capsules have chance of getting deep vein thrombosis, pulmonary embolism, myocardial infarction & stroke.
This type of condition should be treated by initiating prophylactic anti-thrombotic drugs.
The patients who are acquiring this condition then thromboprophylaxis should be provided

DRUG INTERACTION

Pomalidomide metabolism is mediated by CYP1A2 & CYP3A4.
The concomitant use of Pomired 2mg with CYP1A2 drugs like Fluvoxamine causes elevation of Cmax& AUC of Pomalidomide and concludes as increased concentration of Pomired leads to higher extent of adverse effects associated with Pomalid
In this condition, reduce the dose of Pomired 2mg and recommended.

CONTRAINDICATION

Pomired 2mg should be contraindicated to pregnancy & lactating women. The pregnancy category of Pomired 2mg is X.

SIDE EFFECTS

More common effects :
If taken during pregnancy, Severe life-threatening human birth defects
Fatigue, Weakness, Low white blood cell count, Anemia, Constipation, Nausea, Diarrhea, Shortness of breath, Upper respiratory infections, Back pain, Fever.
Less common effects :
Neuropathy , Dizziness, Confusion.

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