Brand name : Pomyelo
Active ingredient : Pomalidomide
Manufactured : Intas Pharma
Strength : 4mg
Pack : 21 capsules in a container
Category : Anti-neoplastic drug
Pomyelo 4mg is a product which is endorsed by FDA, containing an active anti-cancer drug called Pomalidomide.
Pomyelo 4mg is available as orally bioavailable thalidomide derivative with various therapeutic activities such as;
Pomyelo 4mg is like thalidomide & Lenalidomide with related to decreased rate of serum aminotransferase elevations during treatment.
This may lead to severe liver injury.
Pomyelo 4mg is involved in the treatment for regression & unmanageable multiple myeloma.
Pomyelo 4mg is used in the patients who are failing to response for Lenalidomide treatment.
Pomyelo 4mg is used in combination with dexamethasone.
The major therapeutic indication of Pomyelo 4mg is involved in the treatment of multiple myeloma.
This treatment is occurred by combining with dexamethasone for reducing the side effect associated with Pomyelo 4mgomide.
Pomyelo 4mg is majorly indicated in patients who are not reacts for prior two therapies like Lenalidomide & proteasome inhibitor.
DOSAGE & ADMINISTRATION
The prescribed dose of Pomyelo in multiple myeloma is 4mg should be administered orally as once a day on day 1 to 21 of reciprocated 28-day cycles.
Pomyelo 4mg should be concomitant with dexamethasone.
Pomyelo 4mg capsules should be taken with or without food.
During hematological toxicities:
ANC (absolute neutrophils count) <500/mcl: Postpone the Pomyelo therapy and provide CBC weekly
ANC more than or equal to 500/mcl: Continue the Pomyelo3mg daily.
Platelets count <25,000/mcL: postpone the Pomyelo treatment & follow the CBC
>50,000/mcL: continue 3mg of Pomyelo
Pomyelo 4mg with potent CYP1A2 inhibitor:
During this combination reduce the dose of Pomyelo by 50%
In renal impairment:
Initial dose of Pomyelo is 3mg
In hepatic impairment:
Mild to moderate condition, an initial dose of Pomyelo is 3mg; in severe condition, the initial dose of Pomyelo is 2mg.
Pomyelo 4mg exhibits various activities like;
Promote apoptosis of hematopoietic cancer cells
Co adjuvant with dexamethasone in both Lenalidomide sensitive & resistant myeloma cells to activate the tumor cell apoptosis
Boosted the T-cells & natural killer cell mediate immunity.
The drug is prohibited the formation of pro-inflammatory cytokines by monocytes.
Interfere with formation of new vessels and leads to inhibit the cell division.
There are two major worsening condition may occur during the treatment using with Pomyelo 4mg.
Embryo fetal damage:
Pomyelo 4mg capsules are contraindicated to pregnancy period.
During the treatment, patients avoid to becoming pregnant.
Use effective contraceptives for preventing pregnancy during therapy.
Venous & arterial thromboembolism:
Patient who are receiving Pomyelo 4mg capsules have chance of getting deep vein thrombosis, pulmonary embolism, myocardial infarction & stroke.
This type of condition should be treated by initiating prophylactic anti-thrombotic drugs.
The patients who are acquiring this condition then thromboprophylaxis should be provided
Pomalidomide metabolism is mediated by CYP1A2 & CYP3A4.
The concomitant use of Pomyelo 4mg with CYP1A2 drugs like Fluvoxamine causes elevation of Cmax& AUC of Pomalidomide and concludes as increased concentration of Pomyelo leads to higher extent of adverse effects associated with Pomalid
In this condition, reduce the dose of Pomyelo 4mg and recommended.
Pomyelo 4mg should be contraindicated to pregnancy & lactating women. The pregnancy category of Pomyelo 4mg is X.
More common effects :
If taken during pregnancy, Severe life-threatening human birth defects
Fatigue, Weakness, Low white blood cell count, Anemia, Constipation, Nausea, Diarrhea, Shortness of breath, Upper respiratory infections, Back pain, Fever.
Less common effects :
Neuropathy , Dizziness, Confusion.