Azel 160mg Tablet

Description of Azel 160mg (Enzalutamide 160mg) Capsule 

Azel 160mg capsule  contains  active medical substances  enzalutamide 160mg, which is used to treat the prostate cancer in the men. This drug acts as an androgen receptor inhibitor and tries to block the male hormones known as androgens, which usually help cancer cells to grow.

Indications of Azel 160mg (Enzalutamide 160mg) capsule 

Men who have metastatic castration-resistant prostate cancer are most often recommended the Azel 160 mg (Enzalutamide 160 mg) capsule. It can also be given to certain people with non-metastatic castration-resistant prostate cancer if their circumstances are kind of appropriate.

Mechanism of action of Azel 160mg (Enzalutamide 160 mg) capsule 

Enzalutamide assists by stopping signals from the androgen receptors, which reduces the ability of androgens to assist the growth of prostate cancer cells. This interruption leads to less spreading of cancer cells and more of the cells dying.

How to consume Azel 160mg (Enzalutamide 160mg) capsules 

People must use the enzalutamide capsule strictly in the amount the doctor decides for you. Most often, the drug is taken one time every day, and you can take it with food or without having any food. You have to make sure about swallowing each capsule whole and should not break, chew, or open it.

Side Effects of Azel 160mg (Enzalutamide 160mg) Capsule

1. Common side effects

• Feeling tired
• Experiencing hot flashes
• Problems with diarrhea
• Joint hurting
• Appetite gets lower

2. Serious side effects

• Having seizures sometimes
• Indications of liver trouble (like having yellow skin or eyes)
• Allergic issues (rashes, itchiness, or swelling)

3. Rare side effects

• Heart-related cases (myocardial infarct, for example)
• Bones can break.
• Mood or action changes

Safety Advice for Azel 160mg (Enzalutamide 160mg) Capsule

People who are using enzalutamide need proper checking for probable bad impacts, for example, nerve symptoms including seizures. The doctor might ask for frequent checking of the liver working too.

Breastfeeding: Azel 160mg Capsule is not safe to use during lactation. There are Datas available for toxicity in infants depending upon the level of dosage of drug being used. Azel 160mg Capsule is not safe during lactation. Please consult your doctor for more details

Pregnancy :Use of Azel 160mg Capsule is contraindicated in pregnant women as it has positive evidence of increased risk of fetal occurrence. However, it can be prescribed by physicians if the risk, benefit analysis shows its use more desirable.

Alcohol: There must be a reduction in taking alcohol since it might give a higher risk of some impacts.

Liver: Patients having liver problems should use with care.

Lungs: If some lung disease is already there, it must be talked about with your doctor before you start.

Kidney: Patients having kidney problems should use with care.

Driving: Tiredness and feeling dizzy can be possible, so machines and driving must be done with care.

Interaction of Azel 160mg (Enzalutamide 160mg) capsule 

• Drug-Drug Interaction: 

Gemfibrozil x Enzalutamide

It is contraindicated to use this medicine because the use of gemfibrozil will increase the effect of enzalutamide by decreasing its metabolism.

Voriconazole x Enzalutamide

It is contraindicated to use this medicine because the use of voriconazole will increase the effect of enzalutamide by affecting its hepatic enzyme metabolism.

Amlodipine x Enzalutamide

Use an alternative drug because the use of enzalutamide will decrease the effect of amlodipine by affecting its hepatic enzyme metabolism.

Calcifediol x Enzalutamide

Therapy should be administered with caution because the use of enzalutamide may stimulate the microsomal hydroxylation, which reduces the half-life of calcifediol.

• Drug-Food Interaction:

Caffeine

Kindly avoid consuming caffeine like coffee, tea, or energy drinks while you are receiving this medicine because the use of this medicine may cause insomnia, anxiety, and restlessness in some patients.

Alcohol:

Consuming alcohol while you are receiving this medicine may cause confusion, drowsiness, and dizziness, which may increase the risk of accidents.

• Drug-Disease Interaction:

Renal Impairment:

Therapy should be administered with caution because the use of enzalutamide has not been studied in patients who are with severe or end-stage kidney diseases.

Seizures:

Therapy should be administered with caution in patients who have a history of seizures, trauma, head injury, cerebrovascular accident, brain tumor, or infection because the use of this medicine may cause seizures, so kindly discontinue the medicine if you have a history of seizures or develop seizures during treatment.

Contraindication of Azel 160mg (Enzalutamide 160mg) Capsule 

It is contraindicated to use this medicine in patients with a history of seizures.

The use of this medicine may cause posterior reversible encephalopathy syndrome.

Dosage of Azel 160mg (Enzalutamide 160mg) capsule 

The usual suggested amount stays at 160 mg orally each day. The doctor may make changes depending upon personal tolerance and how the treatment is working.

Storage of Azel 160mg (Enzalutamide 160 mg) capsules 

Capsules of enzalutamide need to be kept somewhere with average room temperature conditions, protecting them from too much moisture or heat. You should always have them inside the packet they are in and out of reach of children.

Missed Dose of Azel 160mg (Enzalutamide 160mg) Capsules

If you miss one capsule, just use the next planned dose on the regular schedule. Taking two capsules together to replace a missed one is not required. Do not try to increase your next dose for this.

Other General Information of Azel 160mg (Enzalutamide 160mg) Capsules 

 The use of Azel 160mg Capsule might create dry skin, so using proper moisturizer is recommended by the doctors. Stay hydrated by drinking water and eat as balanced as you can. Attending frequent checkups with a doctor is important during treatment; you should report any strange side effects as soon as possible. If you want further instructions or details for your case, contact your doctor.

FAQs about  Azel 160mg (Enzalutamide 160mg) capsule

1. What needs to be done if you have missed your dose?

If you missed the dose, take it as soon as possible unless it is time for the next scheduled dose. Kindly avoid taking two tablets at once.

2. Is it possible to use Enzalutamide with other medicines?

You should always let the doctor know about any medicines you take so that unwanted interactions are prevented.

3. What is necessary if an overdose happened?

If you take too much of the medicine, immediately talk with your doctor for medical help.

4. Can I take other medicine along with Enzalutamide?

Kindly inform your doctor about your medication history during consultation because some drugs may increase the side effects.

5. Should I continue if I feel better?

No, do not stop this medicine once you feel better because sudden withdrawal with completing the full course of treatment may make the cancer cells to grow faster.

 

Fact Box of Azel 160mg Capsule:

 

Field	Details
Generic/Molecule Name	Enzalutamide
Therapeutic Class	Anti-androgen
Pharmacological Class	Androgen receptor blocker
Dosage form	Capsule
Habit forming	No
Indication	1.      Metastatic prostate cancer can be managed by using hormone therapy or surgery  which reduce the level of testosterone 2.      Non-metastatic prostate cancer with high risk of spreading.

 

 

References

• Enzalutamide. [Accessed 27 Mar. 2019] (online) Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Enzalutamide
• Netherlands: Astellas Pharma Europe B.V.; [Accessed on 27 Mar. 2019] (online) Available from: https://www.ema.europa.eu/en/documents/product-information/xtandi-epar-product-information_en.pdf
• [Internet]. Medlineplus.gov. 2018 [cited 19 December 2018]. Available from: https://medlineplus.gov/druginfo/meds/a612033.html
• [Internet]. Drugbank.ca. 2018 [cited 19 December 2018]. Available from: https://go.drugbank.com/drugs/DB08899