Brespal 125 Capsule

Description of Brespal 125 (Palbociclib 125mg) capsule 

Palbociclib 125mg capsules (Brespal) is a therapeutic agent that is used in the treatment of the selected subtypes of breast-cancer. Its pharmacologic effect is exerted by inhibition of cyclin related kinases, thus hindering the activity of proteins that are very fundamental in the proliferation and the spread of malignant cells.

Indications of Brespal 125 (Palbociclib 125mg) capsule 

Brespal 125 capsule is used in the treatment of HER2-negative advanced or metastatic breast cancer. It is given along with hormonal therapies such as letrozole or fulvestrant. This capsule helps the patient whose diseases is progressed after early treatment.

Mechanism of action of Brespal 125 (Palbociclib 125mg) capsule 

Brespal 125 capsule is a cyclin dependent kinase inhibitor that produces its action by inhibiting the certain chemical messengers cyclin dependent kinase 4 and 6 which helps to arrest the cycle of cancer cell.

How to consume of Brespal 125 (Palbociclib 125mg) capsule

People must use Palbociclib 125mg capsule strictly in amount the doctor decides for you. Most often, drug is taken one time every day, and you can take it with food. You have to make sure about swallowing each capsule whole and should not break, chew or open it.

Side Effects of Brespal 125 (Palbociclib 125mg) capsule 

1. Common side effects

• Feeling tired
• Nausea or vomiting
• Problems with diarrhea
• Mild hair loss
• Appetite gets lower

2. Serious side effects

• Shortness of breath
• Indications of liver trouble (like having yellow skin or eyes)
• Allergic issues (rashes itchy, or swelling)
• Severe bleeding

3. Rare side effects

• Breathing difficulty
• Tiredness due to low red blood cells
• Severe stomach pain

Safety Advice for Brespal 125 (Palbociclib 125mg) capsule

People who are using Palbociclib need proper checking for probable bad impacts, for example, low blood cell counts, tiredness or risk of infection. The doctor might ask for often checking of the liver and kidney working too. You must notify your doctor in case you have a fever, chills, or infection when taking this drug.

Breastfeeding: Taking of this drug is regarded as not safe during breastfeeding. There are animal studies which suggest possible teratogenic effects and would advise against this drug during the nursing peroid.

Pregnancy: The drug is not to be used during pregnancy or in the case of a planned baby as it can pose a danger to the development of the foetus. It is best to seek advice with a trained medical practitioner.

Alcohol: The concomitant effect of this drug with alcohol is not well known in terms of its safety.

Liver: Patients having liver problems should use with care.

Lungs: If some lung disease is already there, it must be talked with your doctor before you start.

Kidney: Patients having kidney problems should use with care.

Driving: Tiredness and feeling dizzy can be possible, so machines and driving must be done with care.

Interaction of Brespal 125 (Palbociclib 125mg) capsule 

• Drug-Drug Interaction :

Palbociclin x Clarithromycin

The other agent should be the clarithromycin since it can increase the effect of palbociclib by changing the enzymatic pathways of the liver and intestine.

Vaccine Cholera x Palbociclib

The combination of palbociclib and the cholera vaccine should be approached with caution as palbociclib can lead to the weakening of the vaccine because of its ability to make a person more susceptible to infection.

Palbociclib x Dichlorphenamide

Careful therapy is to be used since the interaction of dichlorphenamide and palbociclib can lower potassium levels in the blood.

Palbociclib x Carbamazepine 

Another form of therapy is to be used because carbamazepine is known to reduce the plasma concentration of palbociclib.

Mavorixafor x Palbociclib 

Careful therapy is needed, as mavorixafor can increase the action of palbociclib by alteration of the P -glycoprotein efflux transporter.

• Drug-Food Interaction:

Alcohol:

Consuming alcohol while you are receiving this medicine may cause confusion, drowsiness and dizziness which may increase the risk of accidents.

• Drug-Disease Interaction:

Lung toxicity:

Therapy should be administered with caution in patients with history of lung toxicity because the use of this medicine may cause interstitial lung disease, and pulmonary fibrosis.

Hepatic impairment:

Therapy should be administered with caution in patient with liver dysfunction because the pharmacokinetics of this medicine have not been studied in moderate or severe liver impairment.

Neutropenia:

Therapy should be administered with caution because the use of this medicine may cause neutropenia sp kindly monitor the patients complete blood counts before initiating the treatment.

Contraindication of Brespal 125 (Palbociclib 125mg) capsule 

This drug should be used in individuals who portray the hypersensibility to the medication.

The use of this treatment agent is linked with neutropenia, pneumonitis, and the embryo-fetal toxicity.

Dosage of Brespal 125 (Palbociclib 125mg) capsule 

Dose depends on the type of cancer. The doctor may make changes depending upon personal tolerance and how the treatment is working.

Storage of Brespal 125 (Palbociclib 125mg) capsule 

Palbociclib capsules must be stored in ambient room temperature to avoid the capsules becoming overly moist or hot. You should always have them inside packet they are in and out of reach of children.

Missed Dose of Brespal 125 (Palbociclib 125mg) capsule 

If you miss one capsule, just use planned next dose on the regular schedule. Taking two capsules together to replace a missed one is not required. Do not try to increase your next dose for this.

Other General Information of Brespal 125 (Palbociclib 125mg) capsule 

The use of Brespal 125 Capsule might create dry skin, so using proper moisturizer is recommended by the doctors. Stay hydrated by drinking water and eat with more balanced as much as you can. Attending frequent checkups with doctor is important during treatment; you should notify any strange side effects as soon as possible. If you want further instructions or details for your case, contact your doctor.

FAQs of Brespal 125 (Palbociclib 125mg) capsule 

1.Which measures are to be considered in case of feeling especially tired or lightheaded?

When either of the two symptoms is met, it is necessary to inform the treating physician immediately so that the correct dosage can be adjusted.

2.Is it possible to use Palbociclib with other pharmacological drugs concomitantly?

The clinician should be informed by the patient of all the medications that she is currently taking to prevent possible adverse drug interactions.

3.Which is the ideal span of Palbociclib treatment?

It is recommended to take the dosage in the intervals prescribed by the medical professional; sudden withdrawal can trigger too severe side effects.

 4.Do the side effects of Brespal 125 mg capsules being irreversible?

In most cases, these effects are reversible and they are most likely to be cured when the medication is stopped.

 5.Is Brespal 125 mg capsules administration associated with blood count follow-up?

In fact, this drug may reduce haematological values; hence, leukocytes, erythrocytes, and platelets in treatment should be monitored at the start of the treatment.

Fact Box of Brespal 125 (Palbociclib 125mg) capsule:

References

• DrugBank – Palbociclib: Uses, Interactions, Mechanism of Action
  https://go.drugbank.com/drugs/DB09073
• FDA / IBRANCE® (Palbociclib) Prescribing Information (Detailed Indications & Usage)
  https://labeling.pfizer.com/ShowLabeling.aspx?id=13352
• Drugs.com – Palbociclib: Uses, Dosage, Side Effects, Warnings
  https://www.drugs.com/palbociclib.html
• MedlinePlus – Palbociclib Drug Information
  https://medlineplus.gov/druginfo/meds/a615013.html
• Cancer Research UK – Palbociclib (Ibrance) Information for Patients
  https://www.cancerresearchuk.org/about-cancer/treatment/drugs/palbociclib