Imatikast 100 Tablet

Description of Imatikast 100 (Imatinib 100mg) Tablet

Imatinib 100mg is an anticancer therapeutic used in the treatment of particular hematologic and gastrointestinal cancer. The compound is sold as a tablet by various commercial names such as Imatikast 100. It is a Tyrosine Kinase Inhibitor (TKI) and its antitumor activity is due to selective inhibition of malignant cellular proliferation through the selective blockage of the aberrant protein signaling pathways. As a result, the agent decreases the tumor mass and retards the development of malignant cells.

Indications of Imatikast 100 (Imatinib 100mg) tablet

Imatikast 100 tablet can be used in the treatment o a variety of malignancies such as chronic myeloid leukaemia, acute lymphoblastic leukaemia, gastrointestinal stromal tumours and some types if myeloprolliferative disorders. Prescription of the drug is common amongst patients who have these kinds of malignancies and it can also be used when other forms of therapy have not worked or they are not appropriate.

Mechanism of action of Imatikast 100 (Imatinib 100mg) tablet

Imatinib is a Tyrosine Kinase Inhibitor that suppresses the protein function of abnormal tyrosine kinases especially the BCR-ABL protein that participates in excessive cell proliferation of leukemic cells. Bloackage of these kinases interferes with proliferative and survival cues delivered to malignant cells and slows down their multiplication, as well as contributes to the management of disease progression.

How to consume of Imatikast 100 (Imatinib 100mg) tablet

Use of Imatinib must be in the correct dosing and time as prescribed by a certified medical practitioner. The medicine is usually administered once or twice per day, and it is best using meals and one full glass of water to reduce gastrointestinal irritation. The tablet should also not be crushed or chewed nor broken unless such a directive is given by the prescribing physician..

Side Effects of Imatikast 100 (Imatinib 100mg) tablet

1. Common side effects

• Feeling tired
• Nausea or vomiting
• Problems with diarrhea
• Mild swelling in hands or feet
• Appetite gets lower

2. Serious side effects

• Chest pain, arrhythmia
• Abnormalities of hepatic functioning
• Severe anemia or major decrease of the peripheral blood cell counts
• Severe bleeding

3. Rare side effects

• Irregular heart rhythmical conduction
• Muscle spasm
• Severe stomach pain

Safety Advice for Imatikast 100 (Imatinib 100mg) tablet

Patients under imatinib are advised to have periodic cheque-ups which entail total blood examination, liver function examination, kidney examination, and assessment of fluid condition. The managing clinician recommends regular evaluation in the labs by serials.

Breastfeeding: Imatinib must not beused during lactation period since it may be transferred into breast milk and may cause harm to the baby. It is a decision that a competent medical worker should be consulted .

Pregnancy: Imatinib should not be used in pregnancy since it is tetratogenic.

Alcohol: The use of alcohol should be reduced or avoided because alcohol can increase hepatic-related adverse events.

Liver: Imatinib should be used in patients with established hepatic impairment with close observation by the physician.

Lungs: Patients who have a history of lung disorders are supposed to notify their clinician before they start getting treated.

Kidney: In patients with renal failure, the use of reasonable dose might be necessary to reduce the possible negative effects.

Driving: It is possible that the medication will cause dizziness or vision problems that will lead to a lack of driving ability.

Interaction of Imatikast 100 (Imatinib 100mg) tablet

• Drug-Drug Interaction :

Dihydroergotamine x Imatinib

It is contraindicated to use this medicine because the use of imatinib increases the effect of dihydroergotamine by affecting hepatic enzyme metabolism.

Deferiprone x Imatinib

Use alternative drug because the use of combination of this  medicines either increases the toxicity of the other by pharmacodynamic synergism.

Erdafitinib x Imatinib

Use alternative drug because the use of erdafitinib will increase the effect of imatinib by P-glycoprotein efflux transporter.

Acetaminophen x Imatinib

Therapy should be administered with caution because the use of imatinib will decreases the effect of acetaminophen by decreasing its hepatic clearance.

Dichlorphenamide x Imatinib

Therapy should be administered with caution because the combination of this medicine may decrease the serum potassium level.

• Drug-Food Interaction:

Food:

Do not take grapefruit while you are receiving this medicine because grapefruit may increase the blood levels which leads to slow heart rate. Kindly contact doctor if you have experience dizziness, lightheadedness, shortness of breath, bleeding, weight loss, chills, and diarrhea.

• Drug-Disease Interaction:

Cardiovascular disease:

There is a need to exercise caution when administering this therapeutic agent which has been known to cause arterial and peripheral vascular occlusive, and ischemic cerebrovascular incidents.

Fluid retention:

In Congestive heart failure, close attention should be paid to observation since imatinib treatment can trigger pericardial effusion, pleural effusion, pulmonary edema, or peripheral edema.

Bone marrow suppression:

Pharmacologic exposure to this agent in persons with a history of bone marrow suppression will cause thrombocytopenia, aplastic anaemia, agranulocytosis, and neutropenia and thus therapeutic intervention should be done cautiously. Pulmonary arterial hypertension: The use of this agent has been linked to a high incidence of developing pulmonary arterial hypertension and this may occur through symptoms that include dyspnea, fatigue, hypoxia and retention of fluid.

Pulmonary arterial hypertension:

The clinical information suggests that the exposure to its agent is associated with an increased risk of pulmonary arterial hypertension that has such symptoms as dyspnea, fatigue, hypoxia, and fluid retention.

Contraindication of Imatikast 100 (Imatinib 100mg) tablet

It is contraindicated to use this medicine in patients with hepatic impairment.

The use of this medicine may cause cardiac adverse reactions, tumor lysis syndrome, embroyofetal toxicity, and bleeding.

The use of this medicine increase the risk of fluid retention and pleural effusion.

Groeth retaedation were reported in children

Dosage of Imatikast 100 (Imatinib 100mg) tablet

Dose depends on the type of cancer. The doctor may make changes depending upon personal tolerance and how the treatment is working.

Storage of Imatikast 100 (Imatinib 100mg) tablet

tablets of Imatinib need to be kept somewhere with average room temperature conditions, protecting it from too much moisture or heat. You should always have them inside packet they are in and out of reach of children.

Missed Dose of Imatikast 100 (Imatinib 100mg) tablet

If you miss one tablet, just use planned next dose on the regular schedule. Taking two tablets together to replace a missed one is not required. Do not try to increase your next dose for this.

Other General Information of Imatikast 100 (Imatinib 100mg) tablet

The use of Imatikast 100 tablet might create dry skin, so using proper moisturizer is recommended by the doctors. Stay hydrated by drinking water and eat with more balanced as much as you can. Attending frequent checkups with doctor is important during treatment; you should notify any strange side effects as soon as possible. If you want further instructions or details for your case, contact your doctor.

FAQs of Imatikast 100 (Imatinib 100mg) tablet

1. When Imatinib is administered, it may be done either in the morning or at night?

The point that should not be overlooked is that the drug should be taken at the same time every day. It is crucial to have a regular schedule.

2. What happens if I miss a dose?

In case of an omission of dose, the following should be considered, any dose should be omitted within a gap of 6-8 hours, but dose should be taken at once, an omission of dose after this period should not be taken and regular dose schedule should be observed. It is not advisable that one should take twice the dose.

3. Can Imatinib cause weight gain?

Imatinib is capable of causing fluid retention that is then translated into swelling and subsequent gain of body weight. A sudden weight gain is to be reported immediately to a medical worker.

4. Is it possible to concomitant Imatinib with other medicine?

You should tell your doctor about the history of your medication on consultation given that there are drugs that can amplify the side effects.

5. Does Imatinib have an impact on fertility?

No, the prescription of this drug can lower the fertility rates of both men and women. Please also advise your physician in case you are going to have a baby.

Fact Box of Imatikast 100 (Imatinib 100mg) tablet:

Field	Details
Generic/Molecule Name	Imatinib
Therapeutic Class	Anti-neoplastic agent
Pharmacological Class	Tyrosine kinase inhibitor
Dosage form	Tablet
Habit forming	No
Indication	Blood cancer

 

References

• Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 953.
• Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 692-94.
• Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Imatinib. [Updated 2018 Oct 31]. [Accessed 18 Feb. 2020] (online) Available from https://www.ncbi.nlm.nih.gov/books/NBK501457/
• Natco Pharma Limited. Safety Data Sheet: Imatinib Mesylate. 2019. [Accessed 05 Jul. 2023]. (online) Available from: https://www.lupin.com/US/pdf/19/07/sds-imatinib-mesylate-tablets-march-2019.pdf