Ninlib 200 Capsule

Description of Ninlib 200 (Nilotinib 200mg) capsule

Nilotinib 200mg in Ninlib 200 capsule form in pharmacologic agent used to treat chronic myeloid leukaemia and acute lymphoid leukaemia. This is a tyrosine-kinase inhibitor (TKI) with antitumor property that selectively acts by inhibiting the growth and spread of tumour cells and decreasing tumour burden.

Indications of Ninlib 200 (Nilotinib 200mg) capsule

Ninlib 200 capsule is given for treatment for certain type of blood cancer such as chronic myeloid leukemia (CML), and acute lymphoblastic leukaemia (ALL). This medicine is used in patients who could not be treated with other medicine for leukemia.

Mechanism of action of Ninlib 200 (Nilotinib 200mg) capsule 

Nilotinib capsule is a tyrosine kinase inhibitor that produces its action by inhibiting the abnormal protein which is required for the growth of cancer cell.

How to consume of Ninlib 200 (Nilotinib 200mg) capsule

People must use Nilotinib capsule strictly in amount the doctor decides for you. Most often, drug is taken twice every day, and you can take without having any food. You have to make sure about swallowing each capsule whole and should not break, chew or open it.

Side Effects of Ninlib 200 (Nilotinib 200mg) capsule

1. Common side effects

• Feeling tired
• Headache
• Problems with diarrhea
• Mild swelling in hands or feet
• Appetite gets lower

2. Serious side effects

• Chest pain, arrhythmia
• Hepatic malfunction
• Allergic issues
• Severe bleeding

3. Rare side effects

• Low potassium level in blood
• Muscle spasm
• Severe stomach pain

Safety Advice for Ninlib 200 (Nilotinib 200mg) capsule

People who are using Nilotinib need proper checking for probable bad impacts, for example, low blood cell counts, bleeding, or accumulation of fluid around the lungs. The doctor might ask for often checking of the liver and kidney working too.

Breastfeeding: The use of the drug is regarded as contraindicated during lactation. It is recommended to consult a clinician in order to get additional information.

Pregnancy: The usage of the drug is contraindicated in case of pregnancy because it may have teratogenic effects. It is recommended to consult a clinician to have more information.

Alcohol: There must be a reduction in taking alcohol since it might give higher risk of some impacts.

Liver: Patients having liver problems should use with care.

Lungs: If some lung disease is already there, it must be talked with your doctor before you start.

Kidney: Patients having kidney problems should use with care.

Driving: Sometimes the drug can also cause dizziness or blurring of sight. When such symptoms manifest, patients are advised not to drive or do heavy machinery.

Interaction of Ninlib 200 (Nilotinib 200mg) capsule

• Drug-Drug Interaction :

Dihydroergotamine x Nilotinib

It is contraindicated to use this medicine because the use of nilotinib increases the effect of dihydroergotamine by affecting hepatic enzyme metabolism.

Deferiprone x Nilotinib

Use alternative drug because the use of combination of this  medicines either increases the toxicity of the other by pharmacodynamic synergism.

Dichlorphenamide x Nilotinib

Therapy should be administered with caution because the combination of this medicine decrease the level of serum potassium.

Loperamide x Nilotinib

Therapy should be administered with caution because the combination of this medicine increase the QTc interval.

Acetaminophen x Nilotinib

Therapy should be administered with caution because the use of nilotinib will decreases the effect of acetaminophen by decreasing its hepatic clearance.

• Drug-Food Interaction:

Food:

Do not take grapefruit while you are receiving this medicine because grapefruit may increase the blood levels which leads to slow heart rate. Kindly contact doctor if you have experience dizziness, lightheadedness, shortness of breath, bleeding, weight loss, chills, and diarrhea.

• Drug-Disease Interaction:

Cardiovascular disease:

There should be caution in the administration of this therapeutic agent and its administration has been linked to arterial and peripheral vascular occlusive events, and ischemic cerebrovascular incidents.

Fluid retention:

Therapy should be administered with caution in patients with congestive heart failure because the use of this medicine may cause pericardial effusion, pleural effusion, pulmonary edema and peripheral edema.

Bone marrow suppression:

Pharmacologic exposure to this agent in persons with a history of bone marrow suppression will cause thrombocytopenia, aplastic anaemia, agranulocytosis, and neutropenia and thus therapeutic intervention should be done cautiously.

Pulmonary arterial hypertension:

The clinical information suggests that the exposure to its agent is associated with an increased risk of pulmonary arterial hypertension that has such symptoms as dyspnea, fatigue, hypoxia, and fluid retention.

Contraindication of Ninlib 200 (Nilotinib 200mg) capsule

It is contraindicated to use this medicine in patients with hepatic impairment, low potassium and magnesium level.

QT interval cardiovascular events, and tumor lysis syndrome were reported.

Therapy should be administered with caution in patients with history of pancreatitis.

The use of this medicine may cause hypophosphatemia, hypokalemia, hyperkalemia, hypocalcemia, and hyponatremia.

Dosage of Knilonat 200 (Nilotinib 200mg) capsule

Dose depends on the type of cancer. The doctor may make changes depending upon personal tolerance and how the treatment is working.

Storage of Ninlib 200 (Nilotinib 200mg) capsule

Capsules of Nilotinib need to be kept somewhere with average room temperature conditions, protecting it from too much moisture or heat. You should always have them inside packet they are in and out of reach of children.

Missed Dose of Ninlib 200 (Nilotinib 200mg) capsule

If you miss one capsule, just use planned next dose on the regular schedule. Taking two capsules together to replace a missed one is not required. Do not try to increase your next dose for this.

Other General Information of Ninlib 200 (Nilotinib 200mg) capsule 

The use of Ninlib 200 capsule might create dry skin, so using proper moisturizer is recommended by the doctors. Stay hydrated by drinking water and eat with more balanced as much as you can. Attending frequent checkups with doctor is important during treatment; you should notify any strange side effects as soon as possible. If you want further instructions or details for your case, contact your doctor.

FAQs of Ninlib 200 (Nilotinib 200mg) capsule 

1. What about when one feels extremely tired or lightheaded?

It is advisable that the person should alert his doctor when he experiences such symptoms. The doctor will then alter the dose of the same.

2. When Nilotinib is administered, it may be done either in the morning or at night?

The point that should not be overlooked is that the drug should be taken at the same time every day. It is crucial to have a regular schedule.

3. Is Nilotinib high-speed capsule known to cause bleeding?

Yes, it is possible that the use of this medicine can increase the risk of bleeding. Please tell your physician whether or not you have had blood in your stools.

4. Is it possible to concomitant Nilotinib with other medicine?

You should tell your doctor about the history of your medication on consultation given that there are drugs that can amplify the side effects.

5. Does Nilotinib have an impact on fertility?

No, the prescription of this drug can lower the fertility rates of both men and women. Please also advise your physician in case you are going to have a baby.

Fact Box of Ninlib 200 (Nilotinib 200mg) capsule:

Field	Details
Generic/Molecule Name	Nilotinib
Therapeutic Class	Anti-neoplastic agent
Pharmacological Class	Tyrosine kinase inhibitor
Dosage form	capsule
Habit forming	No
Indication	Blood cancer

 

References

• Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 953.
• Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 980-82.
• Nilotinib [Summary of Product Characteristics]. Dublin, Ireland: Novartis Europharm Limited.