Tagrisso 80 Tablet

Description of Tagrisso 80 (Osimertinib 80mg) tablet

Tagrisso 80 is a tablet dosage comprising 80mg of an anticancer pharmacologic agent, osimertinib that is used primarily in the treatment of a non-small cell lung cancer (NSCLC). It is an antineoplastic drug, a member of the tyrosine kinase inhibitor (TKI) category, which selectively blocks the aberrant signalling transduction pathways, which promote uncontrolled tumour growth and spread of malignant cells. This mechanism is specifically aimed at reducing the pace of the disease and lowering the tumor load of affected patients.

Indications of of Tagrisso 80 (Osimertinib 80mg) tablet

Tagrisso 80 is administered to treat epidermal growth factor receptor (EGFR) mutant prositive non-squamous cell carcinoma of the lung (NSCLC) including those patients who have acquired resistance to previous EGFR-targeted therapy. It is usually administered in situations where molecular testing has proved to be sensitive to EGFR inhibition, or where the other therapeutic means are inappropriate.

Mechanism of action of of Tagrisso 80 (Osimertinib 80mg) tablet 

Osimertinib is a third generation tyrosine kinase inhibitor which works by selectively blocking epidermal growth factor receptor (EGFR) including the resistant mutations like T790M. The drug disrupts intracellular signalling pathways involved in the proliferation and survival of cancer cells by blocking this aberrant activity of the receptor, thus suppressing the multiplication and diffusion of cancerous cells.

How to consume of Tagrisso 80 (Osimertinib 80mg) tablet

Patients are supposed to take Osimertinib as per the prescription given to them by the clinician in terms of dosage and at the exact time. The tablet is usually administered on a daily basis either with or without food. I t is to be swallowed in large whole with water and should not be crushed, chewed or broken unless given special instructions by a medical practitioner.

Side Effects of Tagrisso 80 (Osimertinib 80mg) tablet

1. Common side effects

• Feeling tired
• Headache
• Problems with diarrhea
• Mild swelling in hands or feet
• Appetite gets lower
• Skin rash

2. Serious side effects

• Chest pain, arrhythmia
• Hepatic malfunction
• Allergic issues
• Eye irritation
• Breathing difficulty

3. Rare side effects

• Low potassium level in blood
• Muscle spasm
• Severe stomach pain

Safety Advice for Tagrisso 80 (Osimertinib 80mg) tablet

Patients on Osimertinib are supposed to be subjected to regular medical checkups to identify the risk of adverse events such as skin reaction, intense diarrhea, dyspnea, and changes in hepatic lab tests. Clinicians can also prescribe regular haematological testing and renal functional evaluation under the condition of clinical situation of the patient.

Breastfeeding: This medicine should not be administered when one is on lactation because thers is a risk of therapeutic intervention in breast milk and may lead to a teratogenic or neonatal risk. Before the commencement, consultation with a trained medical professional is necessary.

Pregnancy: This medicine should not be used during pregnancy because it may be teratogenic. Potential women need to use effective contraceptive methods and are to receive specialist counselling before beginning therapy.

Alcohol: Must be limited or avoided because it can increase the rate of hepatotoxicity and mucosal gastrointestinal irritation.

Liver: In patients having hepatic pathology, the administration of Osimertinib must be done with caution and treatment must be done under close medical supervision as it has a tendency of increasing hepatic enzymes..

Lungs: Lung pulmonary inflammation Interstitial lung disease is infrequently linked to Osimertinib. Patients who have a new cough, exacerbated cough, pyrexia, or dyspnea should consult the doctor immediately.

Kidney: Osimertinib is not recommended in patients with renal insufficiency and dosage needs to be changed based on clinical evaluation.

Driving: The drug can cause vertigo, fatigue, or blurring of the vision. In case of such manifestation, patients will be advised not to drive a vehicle or operate a heavy piece of equipment.

Interaction of Tagrisso 80 (Osimertinib 80mg) tablet

• Drug-Drug Interaction :

Apalutamide x Osimertinib

Osimertinib should not be concomitantly used, as Osimertinib increases the effect of apalutamide by altering the hepatic enzymatic metabolism.

Ciprofloxacin x Osimertinib

The use of an alternative antimicrobial must be taken into account, since ciprofloxacin augments the action of Osimertinib by inhibiting its metabolic disposition.

Dichlorphenamide x Osimertinib

The combination should be used with caution as the interaction lowers the levels of serum potassium.

Dexlansoprazole x Osimertinib

Another acid-suppressing drug is also advised, since dexlansoprazole reduces the impact of Osimertinib by increasing gastric pH.

Siponimod x Osimertinib

It is recommended that clinical vigilance be observed because the combination might increase the risk of infection.

• Drug-Food Interaction:

Food:

Grapefruit must be avoided, if in the process of treatment, it may increase the levels ofsystemic drugs and as a result, induce bradycardia. The patient will need to visit the doctor immediately in case of the emergence of such symptoms like dizziness, feeling light-headed, dyspnea, bleeding, weight loss, chills, or diarrhea.

• Drug-Disease Interaction:

Dermatologic toxicities:

Prescription of this drug needs caution as reversible cutaneous reactions have been reported. To reduce sun induced dermatitis patients are recommended to cover their skin with sunscreen and hats.

GI disorders:

Prudent use of the drug is observed in people whose history of peptic ulceration because the drug is linked with gastrointestinal perforation.

Pulmonary toxicities:

Patients with the history of interstitial pneumonitis have to be considered carefully because the drug can trigger interstitial lung disease or fibrosis of the lungs.

Contraindication of Tagrisso 80 (Osimertinib 80mg) tablet

Tagrisso 80 tablet contraindications include interstitial lung disease, myocardial infarction, cerebrovascular accident, microangiopathic hemolytic anemia, gastrointestinal perforation and bullous eruptions.

Dosage of Tagrisso 80 (Osimertinib 80mg) tablet

Dose depends on the type of cancer. The doctor may make changes depending upon personal tolerance and how the treatment is working.

Storage of Tagrisso 80 (Osimertinib 80mg) tablet

Tablets of Osimertinib need to be kept somewhere with average room temperature conditions, protecting it from too much moisture or heat. You should always have them inside packet they are in and out of reach of children.

Missed Dose of Tagrisso 80 (Osimertinib 80mg) tablet

If you miss one tablet, just use planned next dose on the regular schedule. Taking two tablets together to replace a missed one is not required. Do not try to increase your next dose for this.

Other General Information of Tagrisso 80 (Osimertinib 80mg) tablet 

The long-term use can cause xerosis, hence use of an appropriate moisturizer. Enough hydration by drinking water and eating a proper diet must be promoted. Patients have to inform their physicians of any abnormal adverse events and they are supposed to do this regularly. To seek further advice depending on the case scenario, one is recommended to consult the prescribing clinician.

FAQs of Tagrisso 80 (Osimertinib 80mg) tablet 

1. What is the common cause of Osimertinib to cause skin rash?

Epidermal growth factor receptors that Osimertinib targets are also found in epithelial cells of the skin. As a result, acneiform rashes or xerosis can be experienced. Mild eruptions are common and can indicate the effectiveness of the treatment but severe ones require medical treatment.

2. Is it safe to use sunscreen in combination with Osimertinib?

Yes, broad-spectrum sunscreen hats or protective clothing are highly encouraged because the drug enhances photosensitivity of the skin, and lowers the risk of irritation and hyperpigmentaion .

3. What type of food should I avoid taking when an Osimertinib?

Foods with grapefruit or grapefruit juice are to be avoided since they increase the plasma drug levels and increase the chances of side effects, especially spicy or rich foods can contribute to gastrointestinal problems like diarrhea.

4. Does Osimertinib have any impact on breathing?

In some extreme cases, pulmonary inflammation can present. The clinician must be informed immediately on the occurrence of new onset cough, chest tightness, or dyspnea.

5. Is it possible to use antacids or acidity tablet with Osimertinib?

Osimertinib may be reduced by the concurrent use of antacids or proton-pump inhibitors, the use of these types of agents should be approved by the prescribers before starting.

Fact Box of Tagrisso 80 (Osimertinib 80mg) tablet:

References

• AGRISSO® (osimertinib) Tablets, FDA Prescribing Information https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/208065s030lbl.pdf
• TAGRISSO Summary of Product Characteristics (EMA)
  https://www.ema.europa.eu/en/documents/product-information/tagrisso-epar-product-information_en.pdf
• Osimertinib – DrugBank Profile https://go.drugbank.com/drugs/DB09330