Zevtaxel 60 Injection

Description of Zevtaxel 60mg/ml (Cabazitaxel 60mg/ml) injection   

Zevtaxel 60 mg/ml Injection is the anticancer agent Cabazitaxel that is mostly used in treating advanced or metastatic prostate cancer. It is a part of the group of taxane antitumor agents and works by its therapeutic action by stabilising the microtubules thus preventing their normal disaggregation during mitosis. This selective inhibition of the cell division impairs tumour cell growth, which ultimately leads to slowing down of disease progression and lessening the tumour burden among the affected patients.

Indications of Zevtaxel 60mg/ml (Cabazitaxel 60mg/ml) injection 

The main indications of the use of Zevtaxel 60 mg/ml injection include the treatment of advanced prostate cancer marked by metastasis in the bones and blood that has developed resistance to castration therapy. It is regularly given to patients that have already received Docetaxel-based therapy and have to receive further targeted cytotoxic treatment.

Mechanism of action of Zevtaxel 60mg/ml (Cabazitaxel 60mg/ml) injection 

Zevtaxel is injected through a qualified health care expert in hospital or cancer care environment. The dose and infusion time is decided by the treating oncologist basing on the surface area of the body, clinical response and tolerance of the patient. Antihistamines, corticosteroids, and H2 antagonists are normally premedicated to minimise the chances of hypersensitivity reaction.

How to consume of Zevtaxel 60mg/ml (Cabazitaxel 60mg/ml) injection 

Zevtaxel 60mg/ml is administered as an intravenous injection by one of the qualified health-care professionals in a hospital or oncology clinic. The oncologist determines dosage and infusion duration based on aspects such as body surface area, tumour type and patient tolerance. Prophylactic pre-medications, including corticosteroids and antihistamines, are often given in order to reduce the chances of infusion-related hypersensitivity.

Side Effects of Zevtaxel 60mg/ml (Cabazitaxel 60mg/ml) injection 

1. Common side effects

• Hair loss
• Infusion Fever and Chills
• Mild diarrhea
• Nausea or vomiting
• Headache

2. Serious side effects

• Pain in the chest
• Irregular heartbeat
• Increased infection risk

3. Rare side effects

• Extreme increase in liver enzymes
• Severe skin reactions
• Hearing disturbances

Safety Advice for Zevtaxel 60mg/ml (Cabazitaxel 60mg/ml) injection 

Cardiac examination (eg. Echocardiography or left ventricular ejection fraction) and regular liver and blood tests need to be performed on patients treated with Cabazitaxel to identify its side effects in the first place.

Breastfeeding: Interaction with the agent during lactation is not advisable since the agent may be released into breast milk and be dangerous to the baby.

Pregnancy: Cabazitaxel is not to be used in pregnant women because of the likelihood of harming a child, contraception should be used with effectiveness.

Alcohol: Intake of alcohol should be limited since it could increase the effect of hepatotoxicity.

Liver: Patients who have a history of hepatic disorders must use Cabazitaxel cautiously and with strict medical care as the drug may increase the level of hepatic enzymes.

Lungs: New cough, dyspnea and chest discomfort should be reported as soon as possible.

Kidney: Care should be taken in patients with severe renal failure.

Driving: It is possible that patients feel dizzy or fatigued, in this case the patients should avoid driving

Interaction of Zevtaxel 60mg/ml (Cabazitaxel 60mg/ml) injection 

• Drug-Drug Interaction :

Apalutamide x Cabazitaxel 

It should be considered to use some alternative pharmacologic agents because the simultaneous use of apalutamide can reduce the therapeutic effects of Cabazitaxel by influencing the activity of enzymes in the liver.

Eluxadoline x Cabazitaxel

Use alternative drug because the use of Cabazitaxel will increase the effect of eluxadoline by decreasing it metabolism.

Dichlorphenamide x Cabazitaxel

The combination is to be used with caution, since the interaction lowers the serum potassium levels

Siponimod x Cabazitaxel

It is recommended that clinical vigilance be observed because the combination can increase the risk of infection.

Phenytoin x Cabazitaxel 

The use of Cabazitaxel should be thought out, as it may decrease the exposure of phenytoin by increasing the metabolic clearance of the latter.

• Drug-Food Interaction:

Food:

There is no reported food interaction that is significant however, a balanced diet should be maintained.

• Drug-Disease Interaction:

Infections: 

This medicine should not be used in patients with active infections as it can cause myelosuppression that will worsen the existing infections.

Conduction disorders: 

The warning features of this therapeutic agent should be given special attention, as severe conduction abnormalities may occur during the usage of this therapeutic agent.

Peripheral neuropathy: 

The treatment plan should be adopted accurately since it has a chance of causing peripheral neuropathy.

Hepatic dysfunction: 

Patients with a defective hepatic function must be handled with a lot of care, as moderate to severe hepatic dysfunction predisposes one to hepatotoxicity.

Contraindication of Zevtaxel 60mg/ml (Cabazitaxel 60mg/ml) injection 

Zevtaxel 60 mg/ ml injection should be contraindicated in hypersensitivity to Cabazitaxel, severe neutropenia or uncontrolled infections.

Dosage of Zevtaxel 60mg/ml (Cabazitaxel 60mg/ml) injection  

Dose Zevtaxel 60 mg/ml injection will depend upon the type of cancer, weight of the patient and response of the patient. The oncologist may change the treatment according to the tolerance and efficacy of the treatment.

Storage of Zevtaxel 60mg/ml (Cabazitaxel 60mg/ml) injection 

The storage requirements of Zevtaxel 60mg per ml injection include refrigeration between 2-8 o C and light exclusion. Preparation must not be frozen and children must not be allowed to reach the preparation.

Missed Dose of Zevtaxel 60mg/ml (Cabazitaxel 60mg/ml) injection 

In case of a missed infusion, call the healthcare provider so as to reschedule. Do not give two ties its dose.

Other General Information of Zevtaxel 60mg/ml (Cabazitaxel 60mg/ml) injection 

The long-term treatment can trigger exhaustion, neuropathy or xerosis. It is necessary to keep the patient hydrated properly, balance nutrition, and regularly cheque the progress. Atypical manifestations should be reported as soon as possible by the patients.

FAQs of Zevtaxel 60mg/ml (Cabazitaxel 60mg/ml) injection 

1. What is the reason behind the loss of hair with Cabazitaxel?

The drug interferes with the rapidly growing mass of cells, such as the dermal papilla cells of the hair follicles.

2. Is neuropathy reversible?

In many cases, treatment of neuropathic symptoms improves after withdrawal of treatment, in spite of the urgency of reporting the symptoms early.

3. Do you have allergic reactions?

Infusion reactions can take place; concomitant premedication is used to prevent this adverse effect.

4. Is it possible to maintain normal functioning?

The normal activities can be generally continued, as long as the severe fatigue or dizziness do not arise.

5. Is it taken either in isolation or in combination with other substances?

The agent is commonly used together with platinum based chemotherapeutics to improve therapy results.

Fact Box of Zevtaxel 60mg/ml (Cabazitaxel 60mg/ml) injection 

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