Abevmy 400mg (Bevacizumab)

Bevacizumab
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Mylan

Abevmy 400mg (Bevacizumab)

ManufacturerMylanBrand nameAbevmyInternational trade nameAvastinActive substanceBevacizumabStrength400mg/16mlCategoryAnti Cancer

Description  of  Abevmy 400mg (Bevacizumab 400mg)

Category: Monoclonal antibody or Anti-angiogenesis drug Bevacizumab is sold under the brand name Abevmy 400mg (Bevacizumab 400mg) which belongs to vascular endothelial growth factor directed antibody, the main ingredient which is used as BevacizumabAbevmy 400mg (Bevacizumab 400mg) consist of human framework regions and murine complementarity-determining regions. Abevmy 400mg (Bevacizumab 400mg) is a combined human monoclonal antibody IgG1, that predicament to and prohibits the biological activity of human vascular endothelial growth factor (VEGF)

INDICATIONS of  Abevmy 400mg (Bevacizumab 400mg)

Abevmy 400mg (Bevacizumab 400mg)is indicated for the treatment :
• In combination with 5-fluorouracil chemotherapy administered intravenously, first or second line drug of choice for Metastatic colon or rectal cancer
• Concurrent use with carboplatin and paclitaxel as first line therapy for Non-squamous, non-small cell lung cancer
• Used in the treatment of recurrent Glioblastoma in adults
• Concurrent use with interferon alfa for Metastatic renal cell cancer
• Concurrent use with paclitaxel & cisplatin or paclitaxel & topotecan for Metastatic cervical cancer
• In combination with paclitaxel, pegylated liposomal doxorubicin or topotecan for Epithelial ovarian, fallopian tube or peritoneal cancer.

MECHANISM OF ACTION  of  Abevmy 400mg (Bevacizumab 400mg)

Abevmy 400mg (Bevacizumab 400mg)constitute an active ingredient like Bevacizumab which joined to VEGF and will not have communication of VEGF to its receptors like Flt-1 & KDR that present on the surface of the cells. While this interaction inhibits endothelial cell proliferation and new blood vessel production occurs Hence in counts discontinuation of metastatic tumor cells growth happens.

ADME of  Abevmy 400mg (Bevacizumab 400mg)

The pharmacokinetic form of Abevmy 400mg (Bevacizumab 400mg) is assayed by measuring total serum Bevacizumab concentration.
Distribution:
The volume of distribution is 2.9 (22%) L
Elimination:
The terminal half life period of Bevacizumab is 20days (11 to 50days)

 SIDE EFFECTS  of  Abevmy 400mg (Bevacizumab 400mg)

Gastrointestinal perforation and fistulae
Surgery and wound healing complication
Hemorrhage
Arterial thromboembolic events
Venous thromboembolic events
Hypertension
Posterior reversible encephalopathy syndrome
Renal injury & Proteinuria
Infusion reactions
Ovarian failure
Congestive heart failure
Neutropenia, mucosal inflammation, infection, neuropathy, Epistaxis, erythrodysaesthesia.

PRECAUTIONS  of  Abevmy 400mg (Bevacizumab 400mg)

Caution with use in the conditions like;
Previously If you have taking or ever had DPD (dihydropyrimidine dehydrogenase) deficiency of enzyme . Inform the doctor about this then your doctor may preferably inform you avoid taking Abevmy 400mg (Bevacizumab 400mg). Discuss with the doctor that you have or have ever had renal, hepatic, or cardiac problem Discuss with the doctor that are you pregnant or plan to become pregnant. Avoid planning to have children while on treatment with Abevmy 400mg (Bevacizumab 400mg). You should use a essential method of conceiving to prevent pregnancy in yourself or your partner during your treatment with Abevmy 400mg (Bevacizumab 400mg). The drug will harm the fetus. Avoid breast feeding while on treatment with Abevmy 400mg (Bevacizumab 400mg)While using Abevmy 400mg (Bevacizumab 400mg)these are some other complications occurred during therapy, care should be taken Hypertension Posterior reversible encephalopathy syndrome Gastrointestinal perforations Wound healing complications Hemorrhage Arterial thromboembolic events Venous thromboembolic events Embryo fetal toxicity occurs

DRUG INTERACTION  of  Abevmy 400mg (Bevacizumab 400mg)

If you missed a dose take it as soon as possible, if time reach for next dose, While interaction of Abevmy 400mg (Bevacizumab 400mg) with paclitaxel & Carboplatin, leads to lowering in exposure of paclitaxel after four cycles of therapy. Interaction of Abevmy 400mg (Bevacizumab 400mg) with paclitaxel & Carboplatin leads to increase the paclitaxel exposure at day 6

PREGNANCY  of Abevmy 400mg (Bevacizumab 400mg)

 

Pregnancy category: D while administrating Abevmy 400mg (Bevacizumab 400mg) in pregnant women, positive evidence on fetal risk depends on human studies but potential benefits by using the drug may have common risk against fetus.

LACTATION  of Abevmy 400mg (Bevacizumab 400mg)

Abevmy 400mg (Bevacizumab 400mg)is excreted into breast milk taking account on this, discussion should done on whether to discontinue the breast feeding or the drug. While using the drug is unsafe during breast feeding to their infants

DOSAGE of  Abevmy 400mg (Bevacizumab 400mg)

Key point :
Avoid administrating Abevmy 400mg (Bevacizumab 400mg) before at least 28 days following surgery and the wound is completely cured
Metastatic colorectal carcinoma :
The Abevmy 400mg (Bevacizumab 400mg)usual dosage by concomitant with 5-fluorouracil based chemotherapy. Abevmy 400mg (Bevacizumab 400mg)5mg/kg for every 2 weeks IV in concomitant with bolus IFL Abevmy 400mg (Bevacizumab 400mg)10mg/kg for every 2 weeks IV in combination with FOLFOX4 Abevmy 400mg (Bevacizumab 400mg)5mg/kg IV for every 2 weeks or Abevmy 400mg (Bevacizumab 400mg)7.5 mg/kg as IV every 3 weeks by concurrently take with fluoropyrimidine Irinotecan or fluoropyrimidine oxaliplatin based therapy
Non-small cell lung cancer :
The patients regular dosage of Abevmy 400mg (Bevacizumab 400mg)is 15mg/kg IV for every 3 weeks by interacting with carboplatin and paclitaxel
Glioblastoma :
Abevmy 400mg (Bevacizumab 400mg)10mg/kg administered IV for every 2 weeks
Metastatic renal cell cancer :
Concurrent use with interferon alfa.: The usual dose of Abevmy 400mg (Bevacizumab 400mg)is 10mg/kg IV for every 2 weeks
Metastatic cervical cancer :
The usual dose of Abevmy 400mg (Bevacizumab 400mg)Abevmy 400mg (Bevacizumab 400mg)15mg/kg given intravenously for every 3 weeks by combining with paclitaxel and cisplatin or with paclitaxel and topotecan
Epithelial ovarian, fallopian tube or peritoneal cancer :
The usual dose of Abevmy 400mg (Bevacizumab 400mg)for Platinum opposing:; 10mg/kg of Abevmy 400mg (Bevacizumab 400mg)for every 2 weeks by concurrent use with paclitaxel, pegylated liposomal doxorubicin or topotecan Or The regular dosage of Abevmy 400mg (Bevacizumab 400mg); 15mg/kg of Abevmy 400mg (Bevacizumab 400mg)given through IV for every 3 weeks by combining with topotecan The usual dose of Abevmy 400mg (Bevacizumab 400mg)for Platinum responsive; 15mg/kg given IV for 3 weeks in concomitant with carboplatin and paclitaxel for 6 to 8 cycles The recommended dosage of Abevmy 400mg (Bevacizumab 400mg); 15mg/kg of Abevmy 400mg (Bevacizumab 400mg)given IV for 3 weeks by combining with gemcitabine & carboplatin for 6 to 10 cycles.


STORAGE  of  Abevmy 400mg (Bevacizumab 400mg)

Abevmy 400mg (Bevacizumab 400mg)vial should be stored at 2 to 8℃ (36 to 46℉) Single use vial Discard the left out medicine under guidance of pharmacist


MISSED DOSE of  Abevmy 400mg (Bevacizumab 400mg)

If patient fail to take the dose or missed the cycle means must consult with oncologist and follow the regular dosing schedule Do not take overdose.

Brand name:
Abevmy
International trade name:
Avastin
Active substance:
Bevacizumab
Strength:
400mg/16ml
Category:
Anti Cancer
Manufacturer:
Mylan
Packaging:
16ml in 1 Vial
Product form:
Infusion

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