Acivir 800mg (Aciclovir)
Description of Acivir 800mg (Acyclovir 800mg)
Acivir 800mg (Acyclovir 800mg) is also called as Acycloguanosine, which is belongs to antiviral medication.
Acivir 800mg (Acyclovir 800mg) is a type of nucleoside analogs (group of synthetic medicines), will inhibit the symptoms of infection contains Herpes Simplex Virus (HSV), this infection will cause herpes simplex or type of herpes virus VZV (varicella-Zoster virus) and thereby causes shingles and chickenpox.
Acivir 800mg (Acyclovir 800mg) is a prescription medicines administrated orally which is used under the supervision of medical practioners. Acivir 800mg (Acyclovir 800mg) is used with combination of other medications.
Medical use /Indication of Acivir 800mg (Acyclovir 800mg)
Acivir 800mg (Acyclovir 800mg) is used to reduce pain and fast healing of sores or blisters which is caused by varicella (chickenpox), Herpes Zoster.
Acivir 800mg (Acyclovir 800mg) is also used for the treatment of herpes virus infection which causes sore to form around the genitals and rectum from time to time (genital herpes) and hence prevents the outbreaks of genital herpes in people affected by virus.
Mechanism of Action Acivir 800mg (Acyclovir 800mg)
Acivir is stimulated by phosphorylation before to that medicine will inhibits the viral DNA synthesis .
Acivir converted by addition of phosphate group to a viral enzyme known as thymidine kinase has more affinity.
HSV-TK or VZV-TK converts into acyclovir triphosphate by phosphorylation then fused into viral DNA, thereby stops further synthesis of DNA.
Since Acivir attack to a selective type of viral kinase, the medicines enters and works on those cells infected with HSV or VZV, hence it will disorganize the formation of herpesvirus DNA At high concentration has less activity in uninfected cells, Therefore HSV-TK or VZV-TK mutation will leads resistance to acyclovir.
ADME of Acivir 800mg (Acyclovir 800mg)
Absorption of Acivir 800mg (Acyclovir 800mg)
Poorly water soluble, peak plasma concentration after 1-2 hours and bioavailability 15-30%.
Distribution of Acivir 800mg (Acyclovir 800mg)
Plasma protein binding is ranging between 9 to 33%.
Elimination of Acivir 800mg (Acyclovir 800mg)
Half life based according to age group neonates have t1/2 4 hours, children’s have 2-3 hours and for adults t1/2 3 hours
Side effects of Acivir 800mg (Acyclovir 800mg)
Common side effects :
- Weakness
- Vomiting
- Nausea
- Diarrhea
- Headache
SERIOUS SIDE EFFECTS
- Unusal changes in mood like aggressive behavior, confusion, speaking trouble, hallucinations, seizures, Coma.
- Reduced RBC and Platelets like fatigue
- Liver problems
- Myalgia
- Skin reaction like hair loss, rash, breaking or loosening of skin, hives
- Changes in your vision
- Kidney failure like flank pain, bloody urine
Precautions of Acivir 800mg (Acyclovir 800mg)
- Acivir 800mg (Acyclovir 800mg) cause allgeric reaction like breathing trouble, swelling of throat or tongue, rash, hives. Inform your doctor if symptoms occurs.
- Discuss with your consultant about planning to become pregnant or pregnancy because medicine can be used if possible benefits clarify possible risk to the patients.
- Discuss with doctor If you had kidney disease because the excretion of medicine will not perform well, Acivir 800mg (Acyclovir 800mg) will decrease the kidney function.
Drug interaction of Acivir 800mg (Acyclovir 800mg)
- When concomitant with probenecid will decrease tubular secretion of acyclovir and rise the blood plasma and half- life of acyclovir.
- Concomitant use with nephrotoxic medicines may cause increase the risk in renal function
- Interact with immunostimulators will enhancing effects of acyclovir
Contraindication of Acivir 800mg (Acyclovir 800mg)
Acivir is contraindicated in patients who causes hypersensitivity to acyclovir or valacyclovir.
Pregnancy of Acivir 800mg (Acyclovir 800mg)
Category B: In animal studies it has not shown risk to the fetus and In human no enough studies carried out in pregnant women to describe the risk to the fetus. Medicine used only if possible benefits clarify possible risk to the patients.
Lactation of Acivir 800mg (Acyclovir 800mg)
Mother should decided whether to stop medication or breastfeeding because Acivir 800mg (Acyclovir 800mg) may pass into breast milk and cause adverse reaction to the infants who is feeding.
Dosage of Acivir 800mg (Acyclovir 800mg)
Herpes simplex- mucocutaneous/ immunocompetent host
For adult dose: 200mg orally every 4 hours or 5 times a day for 10 days.
For 5 to 10 days 400mg orally 3 times a day is given.
For pediatric dose: less than 12 years 40 to 80mg/kg/day orally, it can be divided into 3 to 4 times a day, max 5 to 10 days
Max dose up to 1000mg/day
12yrs or older: 200mg orally 5 times a day every 4 hours
400mg orally 3 times a day
Duration: 7 – 10 days
Herpes simplex - mucocutaneous/ immunocompromised host
For adult dose: 400mg orally 3 times a day
Duration: up to 5 to 10 days
Severe disease: 5mg/kg IV every 8 hours
Episodic treatment: 400mg orally 3 times a day upto 5 to 14 days
For pediatric dose: <12 years: 10 mg/kg IV for every 8 hours upto 7 days
12 years or older: 5 mg/kg IV for every 8 hours upto 7 days
continues HIV infection
Mild Symptomatic Gingivostomatitis:20 mg/kg orally 4 times a day for 7 to 10 days ; Maximum dose: 400 mg
Moderate to Severe Gingivostomatitis:5 to 10 mg/kg IV 3 times a day
Herpes Simplex Encephalitis
For adult dose: 10mg/kg IV for every 8 hours
Duration: 10days and center for disease control and prevention recommends 21 days
For pediatric dose: 3 months to 12 years old : IV 10 to 20 mg/kg for every 8 hours
12 years or older: 10mg/kg IV every 8 hours
Duration: 10days and center for disease control and prevention recommends 21 days
Herpes Zoster
For adult dose: 800mg orally every 4 hours ( 5 times a day) for 7 to 10 days
Immunocompromised host:10 mg/kg IV every 8 hours for 7 days
Treatment Duration 7 to 14-day course (oral plus IV)
For pediatric dose: Immunocompetent Host:
Parenteral:
< 1 year: 10 mg/kg IV every 8 hours for 7 to 10 days
1 year or older: 500 mg/m2 IV every 8 hours for 7 to 10 days
Oral: 12 years or older: 800 mg orally 5 times a day for 5 to 7 days
Immunocompromised Host: 10 mg/kg IV every 8 hours for 7 to 10 days
Over dosage of Acivir 800mg (Acyclovir 800mg)
Acivir 800mg (Acyclovir 800mg) involving ingestion of 100 capsules ( 20g) have been reported has agitation, coma, seizures and lethargy
Storage of Acivir 800mg (Acyclovir 800mg)
Store at 15℃ to 25℃
Keep away from light
Avoid storing of medicine in moist or damp areas.
Missed dose of Acivir 800mg (Acyclovir 800mg)
If dose missed: immediately administer the medicine as you remember. If next dose time reaches swap the missed dose and continue the regular schedule. avoid taking double dose at a time. Please consult the doctor for further details.
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