Arbitus 250mg (Abiraterone Acetate)

Abiraterone Acetate
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Dr. Reddy’s Laboratories

Arbitus 250mg (Abiraterone Acetate)

ManufacturerDr. Reddy’s LaboratoriesBrand nameArbitusActive substanceAbiraterone AcetateStrength250mgCategoryAnti CancerManufacturerDr.Reddy's

Description  of  Arbitus 250mg (Abiraterone Acetate 250mg)

Abiraterone is sold under brand name Arbitus 250mg (Abiraterone Acetate 250mg), the main ingredient which is used as Abiraterone. Arbitus 250mg (Abiraterone Acetate 250mg) is belongs to type of anti-cancer medicationthat will act by decline the androgen production in the body. Androgen is a male hormone that canmaintance the tumor cell in prostate glands. Actually thisdrug is given by co administration with prednisolone, a steroid which reduce the liability of side effects produced by Abiraterone.

MECHANISM OF ACTION  of  Arbitus 250mg (Abiraterone Acetate 250mg)

Androgens are balancethe production of malignant in prostate. Arbitus 250mg (Abiraterone Acetate 250mg) is belongs to anti androgen drugs, that causes to suppress the enzyme 17α-hydroxylase C 17, 20-lyase (CYP17), it is involves in androgen conglomerate. Reduce the serum testosterone level. Declined the tumor cell occurred.

ABSORPTION OF ACTION  of  Arbitus 250mg (Abiraterone Acetate 250mg)

Time to maximum plasma concentration of Arbitus 250mg (Abiraterone Acetate 250mg) tablet takes 12 hours.

DISTRIBUTION OF ACTION  of  Arbitus 250mg (Abiraterone Acetate 250mg)

Maximum bound to the human plasma protein like albumin and alpha-1 acid glycoprotein.

METABOLISM OF ACTION  of  Arbitus 250mg (Abiraterone Acetate 250mg)

Themain two metabolites of Abiraterone in human plasma are Abiraterone sulphate and N-oxide Abiraterone sulphate.

ELIMINATION OF ACTION  of  Arbitus 250mg (Abiraterone Acetate 250mg)

The drug mainly excreted in 88% feces and 5% in urine Half-life of tablet Arbitus 250mg (Abiraterone Acetate 250mg) is 12 ± 5 hours.

 SIDE EFFECTS  of  Arbitus 250mg (Abiraterone Acetate 250mg)

Common effects :
Fatigue, Arthralgia, Hypertension, Nausea, edema, Hypokalemia, Diarrhea, vomiting, Cough, headache, Glucocorticoid deficiency,Mineral corticoid deficiency, Hepatotoxicity, Hypertension, Decrease in ka level, Adrenocortical insufficiency Musculo skeletal and Connective tissue disorders:Joint swelling, discomfort, muscle discomfort General Disorder:Oedema
Cardiac disorders:Hot flush, hypertension, arrhythmias, chest pain, cardiac failure
GIT disorders:Diarrhea, dyspepsia
Infections and Infestation:UTI
Pulmonary disorder:Cough
Renal:Urinary frequency, nocturia

DRUG INTERACTION  of  Arbitus 250mg (Abiraterone Acetate 250mg)

Interaction of Arbitus 250mg (Abiraterone Acetate 250mg) with dextromethorphan will raises the Cmax and AUC of dextromethorphan Interaction Arbitus 250mg (Abiraterone Acetate 250mg) with strong CYP3A inhibitors or inducers , concomitant use with caution because pharmacokinetics is not evaluated.

OVERDOSAGE  of  Arbitus 250mg (Abiraterone Acetate 250mg)

Arbitus 250mg (Abiraterone Acetate 250mg) has no essential antidote, If overdose occurs end treatment with the drug and give general supportive measures such as monitoring arrhythmias and cardiac failure and assess liver function.

PREGNANCY  of Arbitus 250mg (Abiraterone Acetate 250mg)

Pregnancy category X: while ontherapy with Arbitus 250mg (Abiraterone Acetate 250mg) tablet if women become pregnant, immediately stop the drug and give counseling to the women. Arbitus 250mg (Abiraterone Acetate 250mg) tablet is not recommended for women.

LACTATION  of Arbitus 250mg (Abiraterone Acetate 250mg)

Arbitus 250mg (Abiraterone Acetate 250mg) is not used in women excretion in human milk is unknown and the drug effects in the nursing infant is unknown.

DOSAGE of  Arbitus 250mg (Abiraterone Acetate 250mg)

The prescribed dose of Arbitus 250mg (Abiraterone Acetate 250mg) is initial as 4 tablets given orally once daily. The drug Arbitus 250mg (Abiraterone Acetate 250mg) administrated combination with 5mg prednisolone twice daily in empty stomach. Arbitus 250mg (Abiraterone Acetate 250mg) Tablets given on an empty stomach. Foodshould not be taken for at least 2 hours before and at least 1 hour after the dose of Arbitus 250mg (Abiraterone Acetate 250mg) Tablets is taken. Swallowed whole with water. Chew the tablets or Do not crush

STORAGE  of  Arbitus 250mg (Abiraterone Acetate 250mg)

The drug stored at 15℃-30℃ Keep the drug in dry place.

MISSED DOSE of  Arbitus 250mg (Abiraterone Acetate 250mg)

if a single dose is missed, have the drug probably soon Next dose time reaches then leave the missed dose and continue the regular schedule Please consult with the doctor.

Brand name:
Active substance:
Abiraterone Acetate
Anti Cancer
120 Tablets
Product form:

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