Atavir 300mg capsules (Atazanavir)

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Cipla Ltd

Atavir 300mg capsules (Atazanavir)

ManufacturerCipla LtdBrand nameAtavir Active substanceAtazanavirStrength300mgCategoryHIVManufacturerCipla Ltd

Description of Atavir300mg (Atazanavir 300mg)

Atavir 300mg (Atazanavir 300mg) consist of a peak composition known as Atazanavir, it is an anti-retroviral agent. Anti-retroviral property of the drug Atazanavir demostrated by prevention of the protease enzyme activity. It works by decreasing the amount of HIV virus in blood by interfering with maturation of cells. Atavir 300mg (Atazanavir 300mg) is not a monotherapy; it may combine with other anti-retroviral medicines like Ritonavir. Atavir 300mg (Atazanavir 300mg) tablet is a prescription medicine;

Medical use /Indication of Atavir300mg (Atazanavir 300mg)

Atavir 300mg (Atazanavir 300mg) is an anti retroviral drugs indicated for the treatment of HIV type I infection. Atavir 300mg (Atazanavir 300mg) helps to decrease the amount of HIV virus in blood. It lowers the chance of getting AIDS

Mechanism of Action Atavir300mg (Atazanavir 300mg)

Atavir 300mg (Atazanavir 300mg) is a belongs to a protease inhibitor, this enzyme includes in cleavage of viral polyprotein Atavir 300mg (Atazanavir 300mg) is competent against HIV type I infection, it prohibits the cleavage of Gag-Pol polyprotein. This prevention occurs by Atazanavir active form of Atavir, link to protease enzyme and blocks the action produced by that appropriate enzyme So the prevention of cleavage causes to formation of immature cells.

Absorption of Atavir300mg (Atazanavir 300mg)

The high serum concentration of the drug Atazanavir is occurred within 2.5 hours

Distribution of Atavir300mg (Atazanavir 300mg)

Highly bound to human plasma protein of Atavir 300mg (Atazanavir 300mg) at nearly 86%. If Atavir 300mg (Atazanavir 300mg) taken with food, it may raises the bioavailability and decrease pharmacokinetic variability.

Metabolism of Atavir300mg (Atazanavir 300mg)

In liver Atavir 300mg (Atazanavir 300mg)is largely metabolized and the two major biotransformation pathways in Atavir 300mg (Atazanavir 300mg)is Mono-oxygenation Di-oxygenation

Elimination of Atavir300mg (Atazanavir 300mg)

The excretion exist via feces and urine. The Atavir 300mg (Atazanavir 300mg)half life of the drug is approximately 6 hours.

Side effects of Atavir300mg (Atazanavir 300mg)

>10% :
Total bilirubin level elevated Fever Rash Increased cholesterol Nausea CPK increased Cough Diarrhea Neutrophils counts depleted Jaundice Headache Peripheral neuropathy Insomnia Myalgia Abdominal pain Depression Dizziness Vomiting Prolonged PR interval Diabetes mellitus Edema QTc prolongation, pancreatitis, hepatic function abnormalities, cholelithiasis, arthralgia, alopecia.

PRECAUTIONS of  Atavir 300mg (Atazanavir 300mg)

Atavir 300mg (Atazanavir 300mg) interaction with proton pump inhibitor should not used in treatment experienced patients. if patient getting severe rash or other anaphylactic reactions tablet Atavir 300mg (Atazanavir 300mg)should be stop Caution should be taken in case of Hepatic impairment Renal impairment High bilirubin levels   

Drug interaction of Atavir300mg (Atazanavir 300mg)

Atavir 300mg (Atazanavir 300mg) interaction with some of the list; Carbamazepine, lovastatin, Alfuzosin, astemizole, , Cisapride, Cobimetinib, dihydroergotamine, ivabradine, simvastatin, , pimozide, Phenobarbital, phenytoin, rifampin, sildenafil etc

Contraindication of Atavir300mg (Atazanavir 300mg)

Patients are contraindicated to the ingredients present in the Atavir 300mg (Atazanavir 300mg) tablet Anaphylactic reaction occurs Atavir 300mg (Atazanavir 300mg) is contraindicated in the conditions; Chronic hepatitis B, C Diabetes Lactic acidosis Hemophilia Gallstones Kidney impairment High amount of bilirubin

Pregnancy & Lactation of Atavir300mg (Atazanavir 300mg)

Pregnancy category: B

Treatment experienced pregnant women during II or III trimester: co administration of Atavir 300mg (Atazanavir 300mg)with H2 receptor antagonist or tenofovir, a dose of 400mg with 100mg ritonavir as a single use

Dosage of Atavir300mg (Atazanavir 300mg)

In adults:

HIV-1 infection

Treatment naive :
Atavir 300mg (Atazanavir 300mg)is concomitant use with other anti-retroviral medicine like, Ritonavir The usual dose is 300mg should be given orally as a single dose with Ritonavir 100mg If patient taking Ritonavir is not able to tolerate, 400mg of Atavir 300mg (Atazanavir 300mg)should be taken once a day with food While combination of Efavirenz with Atavir: 400mg PO with 100mg ritonavir qDay
Treatment experienced :
prescribed dose is 300mg orally as a single dose concomitant use with H2 receptor antagonist and Tenofovir is administeres 400mg PO with 100mg ritonavir qDay
Hepatic impairment :
For Mild hepatic impairment is given 400mg PO qDay For Moderate hepatic impairment is 300mg PO qDay Severe: not recommended
Renal impairment :
300mg PO with 100mg ritonavir qDay for Final stage of renal disease hemodialysis: In pediatric: 6-18 years (treatment naïve and treatment experienced) Atavir 300mg (Atazanavir 300mg)is not recommended for <15kg: 200mg PO with 100mg ritonavir qDay for 15kg to <35kg weighing patients 300mg PO with 100mg ritonavir qDay for ≥35kg ≥13 years (patient non tolerated to ritonavir) 400mg PO qDay for patient weighing ≥40kg

STORAGE  of  Atavir 300mg (Atazanavir 300mg)

Atavir 300mg (Atazanavir 300mg) should be stored at room temperature, 68℉ to 77℉(20℃ to 25℃).

Container should be keep away from moisture, heat and light

Missed dose of Atavir300mg (Atazanavir 300mg)

if patient fail to administer the dose, advice them to take within a time. Otherwise the missed dose should be skipped and follow the regular drug schedule


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Cipla Ltd
30 capsules
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