Atazor 300mg capsules (Atazanavir)

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Emcure Pharmaceuticals Ltd

Atazor 300mg capsules (Atazanavir)

ManufacturerEmcure Pharmaceuticals LtdBrand nameAtazorActive substanceAtazanavirStrength300mgCategoryHIVManufacturerEmcure Pharmaceuticals Ltd

Description of Atazor 300mg (Atazanavir 300mg)

Atazor300mg (Atazanavir 300mg)consist of a peak composition known as Atazanavir, it is an anti-retroviral agent. Anti-retroviral property of the drug Atazanavir demostrated by prevention of the protease enzyme activity. It works by decreasing the amount of HIV virus in blood by interfering with maturation of cells. Atazor300mg (Atazanavir 300mg)is not a monotherapy; it may combine with other anti-retroviral medicines like Ritonavir. Atazor300mg (Atazanavir 300mg) capsule is a prescription medicine;

Medical use /Indication of Atazor300mg (Atazanavir 300mg)

Atazor300mg (Atazanavir 300mg) is an anti retroviral drugs indicated for the treatment of HIV type I infection. Atazor300mg (Atazanavir 300mg) helps to decrease the amount of HIV virus in blood. It lowers the chance of getting AIDS

Mechanism of Action Atazor300mg (Atazanavir 300mg)

Atazor300mg (Atazanavir 300mg) is a belongs to a protease inhibitor, this enzyme includes in cleavage of viral polyprotein Atazor300mg (Atazanavir 300mg)is competent against HIV type I infection, it prohibits the cleavage of Gag-Pol polyprotein. This prevention occurs by Atazanavir active form of Atavir, link to protease enzyme and blocks the action produced by that appropriate enzyme So the prevention of cleavage causes to formation of immature cells.

Absorption of Atazor300mg (Atazanavir 300mg)

The high serum concentration of the drug Atazanavir is occurred within 2.5 hours

Distribution of Atazor300mg (Atazanavir 300mg)

Highly bound to human plasma protein of Atazor300mg (Atazanavir 300mg)at nearly 86%. If Atazor300mg (Atazanavir 300mg) taken with food, it may raises the bioavailability and decrease pharmacokinetic variability.

Metabolism of Atazor300mg (Atazanavir 300mg)

In liver Atazor300mg (Atazanavir 300mg) is largely metabolized and the two major biotransformation pathways in Atazor300mg (Atazanavir 300mg) is Mono-oxygenation Di-oxygenation

Elimination of Atazor300mg (Atazanavir 300mg)

The excretion exist via feces and urine. The Atazor300mg (Atazanavir 300mg) half life of the drug is approximately 6 hours.

Side effects of Atazor300mg (Atazanavir 300mg)

>10% :
Total bilirubin level elevated Fever Rash Increased cholesterol Nausea CPK increased Cough Diarrhea Neutrophils counts depleted Jaundice Headache Peripheral neuropathy Insomnia Myalgia Abdominal pain Depression Dizziness Vomiting Prolonged PR interval Diabetes mellitus Edema QTc prolongation, pancreatitis, hepatic function abnormalities, cholelithiasis, arthralgia, alopecia.

Precaution of Atazor300mg (Atazanavir 300mg)

Atazor300mg (Atazanavir 300mg) interaction with proton pump inhibitor should not used in treatment experienced patients. if patient getting severe rash or other anaphylactic reactions tablet Atazor300mg (Atazanavir 300mg)should be stop Caution should be taken in case of Hepatic impairment Renal impairment High bilirubin levels   

Drug interaction of Atazor300mg (Atazanavir 300mg)

Atazor300mg (Atazanavir 300mg) interaction with some of the list; Carbamazepine, lovastatin, Alfuzosin, astemizole, , Cisapride, Cobimetinib, dihydroergotamine, ivabradine, simvastatin, , pimozide, Phenobarbital, phenytoin, rifampin, sildenafil etc

Contraindication of Atazor300mg (Atazanavir 300mg)

Patients are contraindicated to the ingredients present in the Atazor300mg (Atazanavir 300mg)tablet Anaphylactic reaction occurs Atazor300mg (Atazanavir 300mg) is contraindicated in the conditions; Chronic hepatitis B, C Diabetes Lactic acidosis Hemophilia Gallstones Kidney impairment High amount of bilirubin

Pregnancy & Lactation of Atazor300mg (Atazanavir 300mg)

Pregnancy category: B

Treatment experienced pregnant women during II or III trimester: co administration of Atazor300mg (Atazanavir 300mg)with H2 receptor antagonist or tenofovir, a dose of 400mg with 100mg ritonavir as a single use

Dosage of Atazor300mg (Atazanavir 300mg)

In adults:

HIV-1 infection

Treatment naive :
Atazor300mg (Atazanavir 300mg) is concomitant use with other anti-retroviral medicine like, Ritonavir The usual dose is 300mg should be given orally as a single dose with Ritonavir 100mg If patient taking Ritonavir is not able to tolerate, 400mg of Atazor300mg (Atazanavir 300mg) should be taken once a day with food While combination of Efavirenz with Atavir: 400mg PO with 100mg ritonavir qDay
Treatment experienced :
prescribed dose is 300mg orally as a single dose concomitant use with H2 receptor antagonist and Tenofovir is administeres 400mg PO with 100mg ritonavir qDay
Hepatic impairment :
For Mild hepatic impairment is given 400mg PO qDay For Moderate hepatic impairment is 300mg PO qDay Severe: not recommended
Renal impairment :
300mg PO with 100mg ritonavir qDay for Final stage of renal disease hemodialysis: In pediatric: 6-18 years (treatment naïve and treatment experienced) Atazor300mg (Atazanavir 300mg)is not recommended for <15kg: 200mg PO with 100mg ritonavir qDay for 15kg to <35kg weighing patients 300mg PO with 100mg ritonavir qDay for ≥35kg ≥13 years (patient non tolerated to ritonavir) 400mg PO qDay for patient weighing ≥40kg

Storage of Atazor300mg (Atazanavir 300mg)

Atazor300mg (Atazanavir 300mg) should be stored at room temperature, 68℉ to 77℉(20℃ to 25℃).

Container should be keep away from moisture, heat and light

Missed dose of Atazor300mg (Atazanavir 300mg)

if patient fail to administer the dose, advice them to take within a time. Otherwise the missed dose should be skipped and follow the regular drug schedule

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Emcure Pharmaceuticals Ltd
30 capsules
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