Bortenat 3.5mg (Bortezomib)

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Natco Pharma Ltd.

Bortenat 3.5mg (Bortezomib)

ManufacturerNatco Pharma Ltd.Brand nameBortenatInternational trade nameVelcadeActive substanceBortezomibStrength3.5mgCategoryAnti Cancer

Description  of  Bortenat 3.5mg (Bortezomib 3.5mg)

Bortezomib is a drug sold under the brand name of Bortenat 3.5mg (Bortezomib 3.5mg) which belongs to anti-neoplastic medicine, the main ingredient which is used as Bortezomib, which is available in the form of lyophilized powder Bortenat 3.5mg (Bortezomib 3.5mg) is a prime benign proteasome inhibitor; proteasome is a biological structure that clefts the proteins Pharmacological grouped as: anti-neoplastic agent or proteasome inhibitor The drug is an prescription drug given under the supervision of pharmacist

INDICATIONS of  Bortenat 3.5mg (Bortezomib 3.5mg)

Bortenat 3.5mg (Bortezomib 3.5mg) is majorly indicated for the treatment for patients suffering by following disease. Multiple myeloma Mantle cell lymphoma

MECHANISM OF ACTION  of  Bortenat 3.5mg (Bortezomib 3.5mg)

The drug Bortenat is a type of chymotrypsin like activity which is in form of unstable prohibitor of the 26S proteasome in human cells. The 26S proteasome is a group of protein that reduces the agglutinated proteins The various proteins are weakens by proteasome enzymes that make difficult to tumor cells persistence like cyclins, tumor suppressors, BCL-2 & cyclin dependent kinase inhibitors The functioning site of proteasome has Postglutamyl peptide hydrolysis activity Chymotrypsin like Trypsin like Prevention of these degenerations, sensitizes cells to apoptosis and cell arrest and leads to cell lysis

Absorption of  Bortenat 3.5mg (Bortezomib 3.5mg)

The Bortenat 3.5mg (Bortezomib 3.5mg) peak plasma level occurs as 509ng/ml

Distribution of  Bortenat 3.5mg (Bortezomib 3.5mg)

The Bortenat 3.5mg (Bortezomib 3.5mg) has nearly 83% of human plasma protein binding.

Metabolism of  Bortenat 3.5mg (Bortezomib 3.5mg)

Primarily metabolic pathway of Bortenat 3.5mg (Bortezomib 3.5mg) is occurs by deboronation to form 2-deboronated metabolites which are inactive as 26S proteasome inhibitors. In liver Bortenat 3.5mg (Bortezomib 3.5mg) is metabolized with the help of cytochrome P 450 enzymes 3A4, 2C19, & 1A2 by oxidation

Excretion of  Bortenat 3.5mg (Bortezomib 3.5mg)

The half life period of Bortenat 3.5mg (Bortezomib 3.5mg) occurs at 9 to 15 hours In single dose IV;


 SIDE EFFECTS  of  Bortenat 3.5mg (Bortezomib 3.5mg)

Most common side effects occurred after administration of Bortenat 3.5mg (Bortezomib 3.5mg) includes; Burning, crawling, itching, numbness, prickling ; Chest pain ; Black tarry stools; Bleeding gums ; Blood in urine ; Blurred vision ; Body aches, dizziness, faintness, nerve pain, painful urination, pale skin, runny nose, sore throat, stuffy nose, swollen glands, sunken eyes, ulcer, dry mouth, Cough producing mucus, ear congestion, loss of voice

Belching, bone pain, difficulty with moving & bowel movements, cold and shivering, loss of appetite, loss of taste, muscle cramps, muscle pain, stomach discomfort. Vomiting, loss of weight discomfort, increased sensitivity of pain & touch, irregular breathing, heart beats, swelling of peripheral organs, thickening of bronchial secretions


PRECAUTIONS  of  Bortenat 3.5mg (Bortezomib 3.5mg)

While taking Bortenat 3.5mg (Bortezomib 3.5mg) some adverse effects occurs care should be taken in the conditions like Cardiac toxicity Pulmonary toxicity like Acute Respiratory Distress Syndrome, pneumonitis, interstitial pneumonia, lung infiltration. Posterior reversible encephalopathy syndrome-stop the Bortenat 3.5mg (Bortezomib 3.5mg) therapy Bortenat 3.5mg (Bortezomib 3.5mg) leads to peripheral neuropathy like burning sensation, hyperesthesia, hypoesthesia, paresthesia, neuropathic pain Manage postural Hypotension by altering the antihypertensive agents, hydration, and administration of mineralocorticoids or sympathomimetics Gastrointestinal toxicity-fluid or electrolyte replacements have to take Thrombocytopenia and neutropenia Tumor lysis syndrome Hepatic toxicity Embryo fetal toxicity

DRUG INTERACTION of  Bortenat 3.5mg (Bortezomib 3.5mg)

Avoid interaction with st. Johns wort to decrease the exposure of Bortenat 3.5mg (Bortezomib 3.5mg) while concomitant with CYP3A4 inhibitors: there is a chance of getting Bortenat 3.5mg (Bortezomib 3.5mg) toxicity; so to reduce the dose of Bortenat 3.5mg (Bortezomib 3.5mg) Interaction with Strong CYP3A4 inducers: decrease the exposure of Bortenat 3.5mg (Bortezomib 3.5mg) while concomitant with melphalan-prednisone or dexamethasone alone No clinical effect on Bortenat 3.5mg (Bortezomib 3.5mg) exposure.

CONTRAINDICATION of  Bortenat 3.5mg (Bortezomib 3.5mg)

Bortenat 3.5mg (Bortezomib 3.5mg) is administer through IV bolus or subcutaneous; whereas intrathecal administration is contraindicated to the patients who are receiving Bortezomib Hypersensitivity reaction occurs in patients who are contraindicated to Bortenat 3.5mg (Bortezomib 3.5mg), boron, boric acid or glycine

PREGNANCY  & LACTATION  of Bortenat 3.5mg (Bortezomib 3.5mg)

Bortenat 3.5mg (Bortezomib 3.5mg) is not recommended in pregnancy condition. Bortenat 3.5mg (Bortezomib 3.5mg) causes fetal harm and leads to some adverse effect Breast feeding is not recommended

DOSAGE of  Bortenat 3.5mg (Bortezomib 3.5mg)

In adults:
Multiple myeloma:
Previously untreated multiple myeloma In the therapy: Bortenat dose 1.3mg/m2 should be given as 3 to 5 seconds via IV bolus or subcutaneous by interacting with tablet melphalan and prednisolone for nine 6 weeks treatment cycles Bortenat is taken for two times weekly, (day 1, 4, 8, 11, 22, 25, 29 and 32) for Cycles 1 over 4 Bortenat is taken once a week (day 1, 8, 22, and 29) for Cycles 5 over 9 Duration of Bortenat is 72 hours
In Relapse stage:
The usual dose of Bortenat is 1.3mg/m2 should be given via IV bolus or subcutaneous as two times for two weeks (day1, 4, 8, and 11) followed by a ten day rest course (day 12 through 21) Schedule of Treatment increased above 8 cycles may be taken once weekly for 4 weeks (day 1, 8, 15, and 22), followed by 13 day rest (day 23 over 35)
Important points:
Bortenat administrated alone or combination with dexamethasone therapy cycle require of Three week course

STORAGE  of  Bortenat 3.5mg (Bortezomib 3.5mg)

Bortenat 3.5mg (Bortezomib 3.5mg) vial should be stored at 20℃ to 25℃ (68℉ to 77℉); excursion between 15℃ to 30℃ (59℉ to 86℉) Keep away from light and heat

MISSED DOSE of  Bortenat 3.5mg (Bortezomib 3.5mg)

If missed a dose the have it as soon possible or Missed dose should be swapped and continue the regular dosing schedule for avoiding adverse conditions. If missed dose occurs, it should not be resume and continue the next schedule.

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Active substance:
Anti Cancer
Natco Pharma Ltd
1 Vial
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