Celofos 1000mg (Ifosfamide)
Description of Celofos 1gm (Ifosfamide 1gm)
Ifosfamide is generic form of brand name Celofos. Celofos 1gm (Ifosfamide 1gm) is an antineoplastic agent chemically associated to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. Celofos 1gm (Ifosfamide 1gm) is a prescription medicine which is used under the supervision of medical oncologist
INDICATIONS of Celofos 1gm (Ifosfamide 1gm)
- Celofos 1gm (Ifosfamide 1gm)is used for the treatment in patientswith relapsed testicular cancer and germ cell tumors
• Celofos 1gm (Ifosfamide 1gm) is used for the treatment in patients with Sarcomas (soft-tissue, osteogenic sarcoma, Ewing's sarcoma)
• Celofos 1gm (Ifosfamide 1gm) is used for the treatment in patients with Non-Hodgkin's lymphoma
• Celofos 1gm (Ifosfamide 1gm) is used for the treatment in patients with Hodgkin's disease
• Celofos 1gm (Ifosfamide 1gm) is used for the treatment in patients with Non-small cell and small cell lung cancer
• Celofos 1gm (Ifosfamide 1gm) is used for the treatment in patients with Bladder cancer
• Celofos 1gm (Ifosfamide 1gm) is used for the treatment in patients with Head and neck cancer
• Celofos 1gm (Ifosfamide 1gm) is used for the treatment in patients with Cervix cancer
MECHANISM OF ACTION of Celofos 1gm (Ifosfamide 1gm)
The proper mechanism of Ifosfamide has not been described but occur to be like other alkylating agents. Ifosfamide mechanism by sticking the cancer cell’s DNA (the cell’s genetic code) composed so which it can't come apart again. This means which the cell will not multiply and grow.
ADME of Celofos 1gm (Ifosfamide 1gm)
Time to high plasma of Celofos 1gm (Ifosfamide 1gm) is 20-30 minutes and the bioavailability are 90-100%
Volume of distribution is 33L
Celofos 1gm (Ifosfamide 1gm) is extensively metabolized and has metabolites of 3-dechloroethylifosfamide, 2- dechloroethylifosfamide and carboxyifosfamide
Celofos 1gm (Ifosfamide 1gm) is eliminated at high dose of 5000mg/m2 in urine 70-86% and at low dose 1600-2400 about 12-16%.
Half- life for high dose of 3800-5000mg/m2 is 15hr and 7hr for low dose of 1800-2400 mg/m2
SIDE EFFECTS of Celofos 1gm (Ifosfamide 1gm)
- Alopecia
• Malaise
• Dysphagia
• Low WBC count
• Low platelet count
• Loss of hair
• Menopause
• Fertility loss
• Vomiting and nausea
• Hypotension
• Central neurotoxicity
PRECAUTIONS of Celofos 1gm (Ifosfamide 1gm)
- With Celofos 1gm (Ifosfamide 1gm)causes Haemorrhagic cystitis reported
• Stop treatment if it occurs Confusion and coma due to CNS toxicity have been associated with therapy.
• While treatment with Celofos 1gm (Ifosfamide 1gm)may occur Bone marrow suppression
• Dose-related serious myelosuppression occurred
DRUG INTERACTION of Celofos 1gm (Ifosfamide 1gm)
When Celofos 1gm (Ifosfamide 1gm) interaction with CYP3A4 inducers may increase the metabolism of Ifosfamide to its active alkylating metabolites When Celofos 1gm (Ifosfamide 1gm) interaction with CYP3A4 inhibitors may decrease the metabolism of Ifosfamide to its active alkylating metabolites perhaps reducing the effectiveness of Ifosfamide treatment
CONTRAINDICATION of Celofos 1gm (Ifosfamide 1gm)
Celofos 1gm (Ifosfamide 1gm) is contraindicated in patients with Known hypersensitivity
Celofos 1gm (Ifosfamide 1gm) is contraindicated in patients with Urinary outflow obstruction
PREGNANCY OF Celofos 1gm (Ifosfamide 1gm)
Celofos 1gm (Ifosfamide 1gm) will have pregnancy category D
Advice the pregnant women about potential hazard to the fetus and using during pregnancy time is contraindicated
LACTATION of Celofos 1gm (Ifosfamide 1gm)
Avoid breastfeed during the treatment with Celofos 1gm (Ifosfamide 1gm) because potential hazard to the fetus may occur.
DOSAGE of Celofos 1gm (Ifosfamide 1gm)
- Usual adult dose for testicular cancer is 1.2 g/m2, diluted to 50mg/mL IV over 30 minutes once a day with mesna administrated via IV, Oral, or continuous IV infusion given just before and 4 and 8 hours after each dose and aggressive hydration 2 to 4 L/day.
• Celofos 1gm (Ifosfamide 1gm) is commonly administrated for 5days.
Repeated every 3 to 4 weeks :
• The usual dosefor cervical cancer in combination with other cancer medicines as a part of the BIP regimen is 5000mg/m2 over 24 hours on day 2
Cycle repeated every 21 days :
• The usual dose for cervical cancer in combination with other cancer medicines as a part of the BIC regimen is 2000 mg/m2IV on day 1 through 3
Cycle repeated every 21 days :
• Paediatric dose for Malignant disease: The recommended dose is 1200 to 1800mg/m2IV for 3 to 5 days every 21 to 28 daysOr administrated has 5000mg/m2 over 24 hours infusion or 3g/m2/ day for 2 days
STORAGE of Celofos 1gm (Ifosfamide 1gm)
Store the Celofos 1gm (Ifosfamide 1gm) 2 ℃ to 8 ℃
MISSED DOSE of Celofos 1gm (Ifosfamide 1gm)
If the patient fails to take a dose of medicine or missed to take a dose, then should not take an extra dose, but to take the next dose at the regular time, leave the missed dose.
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