Cyclomune 50mg (Cyclosporine)

Cyclosporine
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Sun Pharmaceutical Industries

Cyclomune 50mg (Cyclosporine)

ManufacturerSun Pharmaceutical IndustriesBrand nameCyClomuneActive substanceCyclosporineStrength50mgCategoryNephrologyManufacturerSun Pharmaceuticals

Description of Cyclomune 50mg (Cyclosporine 50mg)

Cyclomune 50mg (Cyclosporine 50mg) belongs to the classification of immunosuppressant medicine largely used in post-allogeneic organ transplant to decrease the action of the patient's immune system and so the organ rejection risk. It has been designed in transplants of skin, heart, kidney, lung, pancreas, bone marrow and small intestine.
Cyclomune 50mg (Cyclosporine 50mg) which used as prescription medicine under the supervision of medical oncologist.

Medical use /Indication of Cyclomune 50mg (Cyclosporine 50mg)

  • Cyclomune 50mg (Cyclosporine 50mg)is used for the treatment ofProphylaxis of organ rejection in kidney, liver, and heart allogeneic transplants; has been used in combination with azathioprine and corticosteroids
  • Cyclomune 50mg (Cyclosporine 50mg) isIndicated for the treatment of severe active, rheumatoid arthritis where the disease has not adequately responded to methotrexate; may be used in combination with methotrexate.
  • Cyclomune 50mg (Cyclosporine 50mg) in adultis Indicated for treatment for nonimmune compromised patients with serious, recalcitrant, plaque psoriasis who have failed to behave to at least 1 systemic treatment.

Mechanism of Action Cyclomune 50mg (Cyclosporine 50mg)

Cyclosporine works by decrease your immune system. White blood cells, part of your immune system, normally fight substances in your body which aren’t there naturally, such as a transplanted organ. Cyclosporine blocks white blood cells from capturing a transplanted organ.
In the case of RA or psoriasis, cyclosporine interruptsyour immune system from wronglyattaching your own body tissues.

ADME of Cyclomune 50mg (Cyclosporine 50mg)

The time to peak plasma concentration is 1.5-2.0 hours and bioavailability is 30%

The medicine has plasma protein bound about 90%

In liver broadly metabolized by the cytochrome P450 3A enzyme system. To lesser degree is metabolized in gastrointestinal tract and kidney.

Mostly excreted in biliary and in urine 6% and 0.1% eliminated in urine as unchanged medicine.

In adults Half-life is 19 hours and in children is 7 hours

Side effects of Cyclomune 50mg (Cyclosporine 50mg)

Serious side effects :

Liver damage :

  • blood in urine
  • dark urine
  • pale stools
  • skin becomes yellow colour or the whites of your eyes
  • pain in your upper abdomen

Kidney damage :

  • blood in urine

Heart problems :

  • swelling of your feet or lower legs

Lung problems :

  • trouble breathing.

More common side effects :

  • In kidneys, blood clots occur
  • Pain in Stomach
  • Hair growth
  • Acne
  • Tremors
  • Headache
  • Hypertension
  • Magnesium level is low in body
  • Gums size increased.

Precautions of Cyclomune 50mg (Cyclosporine 50mg)

  • When usage of Cyclomune 50mg (Cyclosporine 50mg) may have high risk of serious infections. It may also raise the risk of developing a tumor or skin cancer.
  • When Cyclomune 50mg (Cyclosporine 50mg)  treatment reduce the immune system. If you administer this medication, you may be at higher risk for infections from bacteria, fungus, and viruses. These infections may be serious or life-threatening
  • Some patient if have psoriasis and have been treated with either psoralen plus ultraviolet A therapy, methotrexate, coal tar, radiation therapy, or ultraviolet light therapy, you may have anincreased chance of occurring a skin disease while taking Cyclomune 50mg (Cyclosporine 50mg) capsules.
  • When Cyclomune 50mg (Cyclosporine 50mg) treatment may cause hypertension and renal disease.
  • When Cyclomune 50mg (Cyclosporine 50mg) treatment may cause liver repair and liver failure, specifically if you take high doses. It may even be fatal.

Drug interaction of Cyclomune 50mg (Cyclosporine 50mg)

  • Concomitant use ofAdalimumab with Cyclomune 50mg (Cyclosporine 50mg) both increase immunosuppressive effects and cause risk of infection. Avoid the usage of medicine
  • Concomitant use of Cyclomune 50mg (Cyclosporine 50mg) with carbamazepine will reduce the level or effect of cyclosporine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid the usage of medicine or Use Alternate Medicine.
  • Concomitant use of Acyclovir with Cyclomune 50mg (Cyclosporine 50mg) both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.
  • Concomitant use of Azathioprine with Cyclomune 50mg (Cyclosporine 50mg) both increase immunosuppressive effects and cause risk of infection

Contraindication of Cyclomune 50mg (Cyclosporine 50mg)

Cyclomune 50mg (Cyclosporine 50mg) is a contraindicated;

  • Hypersensitivity
  • Breastfeeding
  • Rheumatoid Arthritis (RA)/Psoriasis usage of medicine while in Abnormal renal function, uncontrolled hypertension, malignancies
  • Co administration of PUVA, UVB radiation, coal tar, methotrexate, other immunosuppressants will cause psoriasis

Pregnancy of Cyclomune 50mg (Cyclosporine 50mg)

  • Cyclomune 50mg (Cyclosporine 50mg) Pregnancy category is C
  • The medicine has no sufficient studies done in humans to be certain how the medicine might affect the fetus.
  • Use with caution during treatment with Cyclosporin 50mg

Lactation of Cyclomune 50mg (Cyclosporine 50mg)

The medicine Cyclomune 50mg (Cyclosporine 50mg) excreted via breast milk and may leads to serious bad effects.

Avoid using Cyclomune 50mg (Cyclosporine 50mg) during breastfeeding.

Dosage of Cyclomune 50mg (Cyclosporine 50mg)

Solid Organ Transplantation :

Safety measures of organ rejection in kidney, liver,andheart allogeneic transplants; has been required in concomitant usewith azathioprine and corticosteroids.

In Oral route :

  • The regular dose for4-12 hours pre-transplant is 15 mg/kg orally for 1 dose required
  • The regular dose for 1-2 weeks post-transplant is 15 mg/kg/day orally divided twice daily required.
  • The regular dose for reduce 5% per week until can tolerateis 5-10 mg/kg/day orally divided twice daily required

In Intravenous (IV) route :

  • The regular dose for 4-12 hours pre-transplant IV is 5-6 mg/kg IV for 1 dose over 2-6 hours required.
  • The regular dose for Post-transplant, until can tolerate oral therapy is 5-6 mg/kg IV once/day required.

Solid Organ Transplantation, Pediatric (Off-Label) :

  • In 6 months, young children have getting cyclomune to prevents solid organ transplant rejection.
  • Dosage is same as adults, even if children may need higher mg/kg dose than adults

In Oral route :

  • The regular dose for 4-12 hours pre-transplant is 15 mg/kg orally for 1 dose required
  • The regular dose for 1-2 weeks post-transplant is 15 mg/kg/day orally divided twice daily required.
  • The regular dose for reduce 5% per week until is 5-10 mg/kg/day orally divided twice daily required.

In Intravenous (IV) route :

  • The regular dose for 4-12 hours pre-transplant IV is 5-6 mg/kg IV for 1 dose over 2-6 hours required
  • The regular dose for Post-transplant, until can tolerate oral therapy is 5-6 mg/kg IV once/day required

Rheumatoid Arthritis :

  • Used for severe active, rheumatoid arthritis where the disease has not adequate responded to methotrexate; may be required in
  • concomitant use with methotrexate.
  • Cyclomune 50mg (Cyclosporine 50mg)  the regular dose is 1.25 mg/kg orally twice daily; may increase by 0.5-0.75 mg/kg/day after 8
  • weeks and again after 12 weeks if needed, not to exceed 4 mg/kg/day
  • Stop if no improvement observed by 16 weeks
  • Lowers the dose by 25-50% at any time to regulate adverse effects (e.g., hypertension, elevations in serum creatine greater than 30% pre-treatment level

Psoriasis :

  • The regular dose of Cyclomune 50mg (Cyclosporine 50mg)  is 1.25 mg/kg orally twice daily; may raise by 0.5 mg/kg/day after 4 weeks and every 2 weeks if needed, not to exceed 4 mg/kg/day
  • Stop if no improvement seen at 6 weeks on maximum daily dose of 4 mg/kg/day
  • Lowers the dose by 25-50% at any time to regulateside effects (e.g., high blood pressure, elevations in serum creatine greater than 30% pre-treatment level

Storage of Cyclomune 50mg (Cyclosporine 50mg)

The medicine stored at 20℃ - 25℃.

Do not place medicine in moist or damp areas.

Keep away from light and high temperature.

Missed dose of Cyclomune 50mg (Cyclosporine 50mg)

The patients forget to take a dose then have it soon the missed dose or leave the missed dose and follow regular schedule. Avoid taking extra dose Consult the doctor for more details

Brand name:
CyClomune
Active substance:
Cyclosporine
Strength:
50mg
Category:
Nephrology
Manufacturer:
Sun Pharmaceuticals
Packaging:
50 Capsules
Product form:
Capsules

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