Dasashil 50mg (Dasatinib)

Dasatinib
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Brand nameDasashilActive substanceDasatinibStrength50mgCategoryAnti CancerManufacturerShilpa Medicare Ltd

Description  of  Dasashil 50mg (Dasatinib 50mg)

Dasashil 50mg (Dasatinib 50mg) belongs to oral dual BCR/ABL and Src group of tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukaemia (CML). The main aim of Sprycel, are BCRABL, SRC, Ephrin’s and GFR.
Dasashil 50mg (Dasatinib 50mg) is a prescription drug which used under the supervision of doctor.

INDICATIONS of  Dasashil 50mg (Dasatinib 50mg)

Dasashil 50mg (Dasatinib 50mg) is indicated for the treatment of adult patients having chronic myeloid leukaemia.
Dasashil 50mg (Dasatinib 50mg) is indicated for the treatment of adult patients having acute lymphoblastic leukaemia

 

MECHANISM OF ACTION  of  Dasashil 50mg (Dasatinib 50mg)

Dasatinib is a group of drug which belongs to protein tyrosine kinase inhibitor (TKI). Tyrosine kinases are proteins which work as chemical messengers to stimulate cancer cells to develop. Dasatinib inhibits the tyrosine kinases from passing chemical signals which tell the cells to develop.

Absorption of  Dasashil 50mg (Dasatinib 50mg)

Not available

Distribution of  Dasashil 50mg (Dasatinib 50mg)

volume of distribution 2505 L and plasma protein binding is 96%

Metabolism of  Dasashil 50mg (Dasatinib 50mg)

Extensively metabolized in humans, mainly by the cytochrome P450 enzyme 3A4.

Excretion of  Dasashil 50mg (Dasatinib 50mg)

Dasatinib excreted through the feces.
Half-life is 3-5 hours

 SIDE EFFECTS  of  Dasashil 50mg (Dasatinib 50mg)

  • Skin rash
    • Infection
    • Nausea
    • Dyspnea
    • Anorexia
    • Arthralgia
    • Asthenia
    • Constipation
    • Dizziness
    • Musculoskeletal pain
    • Anemia
    • Febrile neutropenia
    • Thrombocytopenia
    • Mucosal inflammation
    • Diarrhea
    • Headache
    • Haemorrhage
    • Fatigue
    • Pyrexia

 

PRECAUTIONS  of  Dasashil 50mg (Dasatinib 50mg)

Using of Dasashil 50mg (Dasatinib 50mg)  will results in Tumor lysis syndrome; maintain sufficient hydration and correct uric acid levels before to starting treatment
Dasashil 50mg (Dasatinib 50mg)  will causes Risk of fluid retention and pleural/pericardial effusion; manage with supportive care measures and/or dose modification
Myelosuppression which involves severe thrombocytopenia, neutropenia and Anemia may occurs; may manage by dose interference, dose reduction, or blocking of treatment; hematopoietic growth factor has been used with resistant myelosuppression
Advise females of reproductive possible to do not become pregnancy, which may contains the use of effective contraceptive methods, during treatment with Dasashil 50mg (Dasatinib 50mg)  and for 30 days after the final dose.
Certain patients with chronic phase CML and paediatric Ph+ ALL, reveals complete blood cell counts (CBCs) q2Weeks for 12 weeks, then q3Months thereafter, or as clinically indicated; show CBCs for the first 2 months weekly after that monthly,

DRUG INTERACTION of  Dasashil 50mg (Dasatinib 50mg)

Dasashil 50mg (Dasatinib 50mg) concomitant use with CYP3A4 inhibitors will increase Dasatinib plasma concentration.
Dasashil 50mg (Dasatinib 50mg) combination with CYP3A4 inducers will reduces Dasatinib plasma concentration.
Dasashil 50mg (Dasatinib 50mg) combination with antacids will decrease Dasatinib plasma concentration.
Dasashil 50mg (Dasatinib 50mg) combination with H2 antagonists/proton pump inhibitors will decrease Dasatinib plasma concentration.
Dasashil 50mg (Dasatinib 50mg) Interaction with CYP3A4 substrates will have their plasma concentration altered by Dasatinib.

 

PREGNANCY  of Dasashil 50mg (Dasatinib 50mg)

Dasashil 50mg (Dasatinib 50mg) will cause fetal harm while using during pregnancy. Advise a pregnant woman of the possible risk to a foetus.

LACTATION  of Dasashil 50mg (Dasatinib 50mg)

Avoid breast feeding during Dasashil 50mg (Dasatinib 50mg) treatment

DOSAGE of  Dasashil 50mg (Dasatinib 50mg)

Chronic Myeloid Leukaemia :
Dasashil 50mg (Dasatinib 50mg)  indicated for adults with Philadelphia chromosome-positive (Ph+) chronic myeloid leukaemia (CML) in chronic phase and Used for treatment of chronic, accelerated, or myeloid or lymphoid blast phase Ph+ CML with support or intolerance to before therapy contains imatinib
Newly diagnosed
Starting dose with 100 mg PO qDay (morning or evening).
May raised to 140 mg qDay if insufficient response.
Advanced CML:
Starting dose with 140 mg PO qDay
May increase to 180 mg qDay if insufficient reactions
Acute Lymphoblastic Leukaemia :
Dasashil 50mg (Dasatinib 50mg)   indicated for Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukaemia (ALL) with resistance or intolerance to prior therapy
Initiate 140 mg PO qDay
May increase to 180 mg PO qDay if insufficient reactions.


STORAGE  of  Dasashil 50mg (Dasatinib 50mg)

Store at 20℃ to 25℃. Keep away from the children Use the drug before expiry date Protect from direct sunlight. Discard the unused drug by asking the advice from doctor or pharmacist.


MISSED DOSE of  Dasashil 50mg (Dasatinib 50mg)

In case of missed dose, patients must consult with medical oncologist and follow the regular dosing schedule

Brand name:
Dasashil
Active substance:
Dasatinib
Strength:
50mg
Category:
Anti Cancer
Manufacturer:
Shilpa Medicare Ltd
Packaging:
60 Tablets
Product form:
Tablet

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