Efamat 600mg (Efavirenz)

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Efamat 600mg (Efavirenz)

ManufacturerMYLAN PHARMACEUTICALS PVT LTDBrand nameEfamat International trade nameSustiva Active substanceEfavirenz Strength600mgCategoryHIV

Description of Efamat 600mg (Efavirenz 600mg)

Efavirenz is sold under the brand name Efamat 600mg (Efavirenz 600mg) and belongs to antiretroviral medication. Efamat 600mg (Efavirenz 600mg) tablet in concomitant use with other drugs to treat the infection caused by HIV. Efamat 600mg (Efavirenz 600mg) suppress the HIV replication of virus cell and despite the destruction of the immune system. Efamat 600mg (Efavirenz 600mg) may help to delay the problems arises from AIDS/HIV diseases. Efamat 600mg (Efavirenz 600mg)will not curable or preventable HIV/AIDS. The drug is prescription medicine provided under the guidance of medical practioners

Medical use /Indication of Efamat 600mg (Efavirenz 600mg)

Efamat 600mg (Efavirenz 600mg) tablets are anti-retroviral drug which is used in HIV infection, by combining with other anti-retroviral drugs used in adult and childerns 3 months old / weight of 3.5kg

Mechanism of Action Efamat 600mg (Efavirenz 600mg)

The pharmacology of efavirenz is similar to lamivudine. Efavirenz is show activity by prohibiting the activity of viral RNA directed DNA polymerase enzyme which is a reverse transcriptase. The alteration occurs intracellularily to form active triphosphorylated which is specific for the activity of Efavirenz. The phosphorylation occurs based up on the cell type,. The production of DNA duplicates of viral RNA is mediate by inhibition of reverse transcriptase. This generation is necessary for production of new viral assembly. Finally the prohibition causes cell division termination.

Side effects of Efamat 600mg (Efavirenz 600mg)

Psychiatric symptoms, Nervous system symptoms, Rash. Lab abnormalities :
Elevation of AST, ALT, Elevation amylase, Increased glucose level, Neutropenia. The common side effects of efavirenz are :
Anorexia, Nausea, Vomiting , Diarrhea, Dyspepsia, Abdominal pain, Anxiety, Fatigue, Pain, Dizziness, Headache, Insomnia, Abnormal dreams, Depression. Post marketing :
Allergic reactions, Fat redistribution, Ataxia, Convulsions, Hyposthenia, Paresthesia, Neuropathy, Tremor, Vertigo, Gynecomastia, Constipation, malabsorption, Palpitations, An increased hepatic enzyme leads to hepatic failure, Hypercholestremia, Dyspnea, Abnormal in vision.

Precautions of Efamat 600mg (Efavirenz 600mg)

Check the patients with these problems and inform the healthcare providers :
Cholesterol and triglycerides. Redistribution/accumulation of body fat, including central obesity, dorsocervical fat enlargement, peripheral wasting, facial wasting, breast enlargement.. LFTs in patients with history of hepatitis B and/or C.Hepatic Function Use. Immune reconstitution syndrome. Lipids Increases in total cholesterol and triglycerides have been checked, Monotherapy Resistant virus may emerge rapidly. Convulsions Use with caution in patients with history of seizures.. CNS symptoms Liver enzymes in patients with suspected past of hepatitis B or C infection and liver toxicity. Psychiatric symptoms psychiatric disorders may be at greater risk. Some occasional reports of death by suicide, delusions, and psychosis-like behavior. Skin rash Reported in 26% of adults and 46% of children. Over dosage Symptoms Increased CNS symptoms, involuntary muscle contractions.

Drug interaction of Efamat 600mg (Efavirenz 600mg)

Efamat 600mg (Efavirenz 600mg) with psychoactive drugs leads to additive CNS effects and change plasma warfarin concentrations with warfarin. Interaction with HIV integrase inhibitors (dolutegravir), other HIV NNRTIs ( etravirine), HMG-CoA reductase inhibitors ( simvastatin) reduce plasma concentration Efamat 600mg (Efavirenz 600mg) with voriconazole ,plasma concentrations of efavirenz is high and voriconazole is decreased when given continuity. Serious, life-threatening events (e.g. cardiac arrhythmias, respiratory depression) may produce when Efamat 600mg (Efavirenz 600mg) given with terfenadine, astemizole, cisapride, midazolam, triazolam, pimozide, bepridil or ergot alkaloids (ergotamine)

Pregnancy of Efamat 600mg (Efavirenz 600mg)

Efavirenz has category D: Based on adverse effects by investigation and experience studies in humans a positive identification of human fetal risk is reported.

Dosage of Efamat 600mg (Efavirenz 600mg)

The normal advice recommended dose of Efamat 600mg (Efavirenz 600mg)in adults is 600mg of tablet should be administered orally as a single dose by combining with protease inhibitors or nucleoside analogue reverse transcriptase inhibitors. The efavirenz concentration of should be elevated when the Efamat 600mg (Efavirenz 600mg) tablet should be administered with food which leads to increase the adverse effects associated to Efamat 600mg (Efavirenz 600mg). The up take drug at bed time should elevate the tolerability of nervous system symptoms.

Dose alteration :

Concomitant use of Efamat 600mg (Efavirenz 600mg)with voriconazole, the continuance dose of voriconazole should be elevated to 400mg for every 12 hours and the Efamat 600mg (Efavirenz 600mg)dose should be depletes to 300mg as a single dose. Efamat 600mg (Efavirenz 600mg)tablets should not be broke, chew or crush. In combination with rifampin, the dose of Efamat 600mg (Efavirenz 600mg)is 800mg

In pediatrics :

The dose of Efamat 600mg (Efavirenz 600mg)should be suggested for the pediatric patients with the age of 3 years. 10 to < 15kg: given 200mg of efavirenz 15 to <20kg: given 250mg of efavirenz 20 to <25kg: given 300mg of efavirenz 25 to <32.5kg: given 350mg of efavirenz 32.5 To <40kg: given 400mg of efavirenz At least 40kg: given 600mg of efavirenz

Storage of Efamat 600mg (Efavirenz 600mg)

Efamat 600mg (Efavirenz 600mg)store in a closed container at room temperature 25℃

Keep from freezing and reach of children.

Kept away the medicine Efamat 600mg (Efavirenz 600mg) from heat, moisture, and direct light.

Do not uses after expiry date

Ask your consultant about how should dispose of any medicine you do not use.

Missed dose of Efamat 600mg (Efavirenz 600mg)

If missed to take a dose, leave the dose and take your next dose at the normal time or take it as soon as you remember and take your next dose at the normal time. Do not have the extra dose to make up for a missed dose. Please consult with the doctor.

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