Evertor 5mg (Everolimus)
Description of Evertor 5mg (Everolimus 5mg)
Evertor 5mg (Everolimus 5mg) is belongs to class of anti-cancer drugs Evertor 5mg (Everolimus 5mg) contains of an active compound known as Everolimus which is interfere with development of cancer cell and process is slows down. Evertor 5mg (Everolimus 5mg) tablets is not a curable medication, which is helps to slow their spreading into the body.
INDICATIONS of Evertor 5mg (Everolimus 5mg)
The drug Evertor 5mg (Everolimus 5mg) is mainly used for the treatment of following disease • kidney carcinoma • Breast carcinoma • Brain carcinoma Evertor 5mg (Everolimus 5mg) is also used to treat in various advanced stage cancer in stomach, intestines or pancreas.
MECHANISM OF ACTION of Evertor 5mg (Everolimus 5mg)
Everolimus is an prohibitor of mTOR, links at peak compatibility to FK506 binding protein 12, through producing drug complex which prevents the productive of mTOR. This inhibition reduces the activity of effectors downstream, which may lead to stoppage of cell progression from G1 into S phase, finally causes cell growth arrest and apoptosis. Evertor 5mg (Everolimus 5mg) also prohibits the expression of hypoxia-inducible factor, causing to a reduces in the expression of vascular endothelial growth factor. The results of everolimus prevention of mTOR is a reduction in cell multiplication, angiogenesis, and glucose uptake.
ABSORPTION OF ACTION of Evertor 5mg (Everolimus 5mg)
The time to peak plasma concentration of Evertor 5mg (Everolimus 5mg) occurs between 1 to 2 hours.
DISTRIBUTION OF ACTION of Evertor 5mg (Everolimus 5mg)
The drug Evertor 5mg (Everolimus 5mg) has Albumin human plasma protein bound of 74%.
METABOLISM OF ACTION of Evertor 5mg (Everolimus 5mg)
In hepatic Evertor 5mg (Everolimus 5mg) metabolism is take place, which is a substrate of CYP3A4. The Evertor 5mg (Everolimus 5mg) metabolism will occur through 3 processes; • Three monohydroxylated metabolite, • Two hydrolytic rings opened products, • Phosphatidylcholine conjugate of Everolimus.
ELIMINATION OF ACTION of Evertor 5mg (Everolimus 5mg)
The drug excretion primarily through 5% in urine; the parent compound has been detected in urine or feces. The drug half-life period is 30 hours.
SIDE EFFECTS of Evertor 5mg (Everolimus 5mg)
Nephrotoxicity
• Thrombocytopenia
• Hypersensitivity reactions
• Hyperlipemia
• Angioedema
• Lymphomas & other malignancy
• Male infertility
• Proteinuria
• New commencement of diabetes
• Serious infections
• Kidney graft thrombosis
• Hepatic artery thrombosis
• Interstitial lung disease.
DRUG INTERACTION of Evertor 5mg (Everolimus 5mg)
Interaction of Evertor 5mg (Everolimus 5mg) with strong inhibitor of CYP3A4, or P-gp, cause reducing the efflux of Everolimus and high plasma concentration of Everolimus. Concomitant use of Evertor 5mg (Everolimus 5mg) with strong CYP3A4 inducers, will increasing the disclosure of Everolimus. Interaction of Evertor 5mg (Everolimus 5mg) with cyclosporine will increasing the AUC level of Everolimus frequently. Interaction of ketoconazole with Evertor 5mg (Everolimus 5mg) tablet or other CYP3A4 inhibitors will increasing the plasma concentration and AUC of Everolimus. Combination of Evertor 5mg (Everolimus 5mg) with verapamil leads to increasing the plasma concentration of Everolimus. Interaction of Evertor 5mg (Everolimus 5mg) with Atorvastatin or pravastatin leads to rhabdomyolysis, due to increasing concentration of lipid lowering agents. When Evertor 5mg (Everolimus 5mg) combination with rifampicin will reduces the AUC of Everolimus
OVERDOSAGE of Evertor 5mg (Everolimus 5mg)
The over dosage of Everolimus is limited, If over dosage occurs patient must be provide with supportive measures. And monitor evidence of toxicity in Everolimus over dosage
PREGNANCY of Evertor 5mg (Everolimus 5mg)
pregnancy category of everolimus c : in patients Evertor 5mg (Everolimus 5mg) is used only after knowing the benefits to the mother exceed the risk to fetus.
LACTATION of Evertor 5mg (Everolimus 5mg)
Breast feeding should not be suggested
DOSAGE of Evertor 5mg (Everolimus 5mg)
Evertor 5mg (Everolimus 5mg) tablets should be given with or without food. Dosage regimen of Evertor 5mg (Everolimus 5mg) ; In breast cancer, renal cell cancer, pancreatic cancer, Neuro endocrine cancer: The prescribed dosage is 10mg should be taken as a single dose. In Brain or intracranial cancer: The prescribed dosage of Evertor 5mg (Everolimus 5mg) as a single dose. is 4.5mg/m2 given orally In pediatric: The pediatric dosage of Evertor 5mg (Everolimus 5mg) as a single dose in brain or intracranial tumor is 4.5mg/m2 should be given orally.
STORAGE of Evertor 5mg (Everolimus 5mg)
Evertor 5mg (Everolimus 5mg) tablet store at 25℃ Protect the medicine away from moisture, heat and light.
MISSED DOSE of Evertor 5mg (Everolimus 5mg)
if a single dose is missed, have the drug probably soon Next dose time reaches then leave the missed dose and continue the regular schedule Please consult with the doctor.
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