Indivan 400mg (Indinavir )

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Cipla Ltd

Indivan 400mg (Indinavir )

ManufacturerCipla LtdBrand nameIndivanInternational trade nameCrixivanActive substanceIndinavir Strength400mgCategoryHIV

Description of Indivan 400mg (Indinavir 400mg)

Indivan 400mg (Indinavir 400mg) capsule which belongs to a human immunodeficiency protease inhibitor. Indivan 400mg (Indinavir 400mg) is a type of antiviral drug that blocks HIV from replication in our body Indivan 400mg (Indinavir 400mg) is not used for HIV and Aids and it is prescription drug sold under the supervision of doctor

Medical use /Indication of Indivan 400mg (Indinavir 400mg)

Indivan 400mg (Indinavir 400mg) primarily indicated with combination of other antiretroviral for the treatment of HIV infection. The drug uses is based on two clinical trials essentially foe 1 year duration which describes :
Reduction in the risk of AIDS-defining illness or death
A prolonged elimination of HIV RNA.

Mechanism of Action Indivan 400mg (Indinavir 400mg)

An enzyme HIV-1 protease is necessary for the proteolytic gap of the viral polyprotein precursors coalesce to the individual functional proteins create in HIV-1 infectious. Indinavir interpolated to the protease active site and prevents the activity of the enzyme. This hindrance prevents cleavage of the viral polyproteins causing in the formation of immature non-infectious viral particles.

Absorption of Indivan 400mg (Indinavir 400mg) 

Fastly absorbed, time to maximum plasma protein is 0.8±0.3 hrs

Distribution of Indivan 400mg (Indinavir 400mg)

Bounding of human plasma protein of Indivan 400mg (Indinavir 400mg) is 60%

Metabolism of Indivan 400mg (Indinavir 400mg)

In hepatic is metabolized

Elimination of Indivan 400mg (Indinavir 400mg)

< 20% of indinavir is eliminated in the urine unchanged. Half life of Indivan 400mg (Indinavir 400mg) is 1.8 (±0.4) hours.

Side effects of Indivan 400mg (Indinavir 400mg)

More common :
Blood in urine, Just below ribs severe back pain.
Less common :
Abdominal pain, Chills, Loss of appetite, Dizziness, Fever, Headache, Unpleasant breath odor, Vomiting of blood, Rare cases, Confusion, dehydration, dry or itchy skin, fruity mouth odor, increased hunger, increased urination, pale skin, troubled breathing with exertion, unusual bleeding or bruising, unusual tiredness or weakness, vomiting, weight loss.

Drug interaction of Indivan 400mg (Indinavir 400mg)

Concomitant use with drugs that induce CYP3A4 activity will raises the clearance of indinavir, reports in lowering of plasma concentrations of indinavir Interaction of indinavir with drugs metabolized by CYP3A4 wills increases plasma concentration of the other drugs.

Precaution of Indivan 400mg (Indinavir 400mg)

Hemolytic Anemia : Acute hemolytic anemia includes cases result in death. Hence stop the course of Indivan 400mg (Indinavir 400mg) capsules
Hepatitis : The patient having hepatitis has been treated with Indivan 400mg (Indinavir 400mg) will leads to hepatic failure and death
Nephrolithiasis/ urolithiasis : Nephrolithiasis events cumulative frequency increase with increasing exposure of Indivan 400mg (Indinavir 400mg) hence risk over time remains the same
Fat redistribution: The mechanism and long term consequence of these events are currently unknown. A causal relationship has not been established.

Contraindication of Indivan 400mg (Indinavir 400mg)

Indivan 400mg (Indinavir 400mg) contraindicated in Hypersensitivity to any of its components Inhibition of CYP3A4

Pregnancy of Indivan 400mg (Indinavir 400mg)

There have no sufficient and well controlled studies in pregnant women. It should be used when possible benefit clarify the potential risk of the fetus

The drug is unknown whether excreted in human milk, breast feeding mothers to be advice to stop if they receive Indivan 400mg (Indinavir 400mg)

Lactation of Indivan 400mg (Indinavir 400mg)

While taking  Indivan 400mg (Indinavir 400mg) , Breast feeding should not be recommended.

Dosage of Indivan 400mg (Indinavir 400mg)

The prescribed dosage for adult is Indivan 400mg (Indinavir 400mg) is 800mg administer as two 400mg capsules given orally every 8 hours in concomitant use with other antiretrovirals to treat HIV infections. Combination with Ritonavir then 800mg plus Ritonavir 100mg to 200mg twice a day The patients taking Indivan 400mg (Indinavir 400mg) must be take intervals of 8 hours Indivan 400mg (Indinavir 400mg) should given without food with water 1 hour before or 2 hours after meal. It can be also taken with other liquids such as skim milk,juice,coffee or tea or with a light meal The patients ensure adequate hydration its prescribed adults drinks at least 1.5 liters of liquids during the course of 24 hours

Storage of Indivan 400mg (Indinavir 400mg)

Indivan 400mg (Indinavir 400mg) tablets container should be stored at room temperature at below 30 ℃ (86 ℉)  Indivan 400mg (Indinavir 400mg) containers should be keep away from moisture, heat and light

Missed dose of Indivan 400mg (Indinavir 400mg)

If patients missed a dose then have the drug while you remember before next dose timing or skip the missed dose and follow regular schedule Please consult with the doctor 

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Cipla Ltd
30 capsules
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