Isentress 400mg (Raltegravir)

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Brand nameIsentressActive substanceRaltegravirStrength400mgCategoryHIVManufacturerMSD

Description  of  Isentress 400mg (Raltegravir 400mg)

Raltegravir is chemically sort by type as derivative of pyrrolidinone. Isentress 400mg (Raltegravir 400mg) tablets are belongs to as anti-retroviral medicine by involving an active ingredient known as Raltegravir which is efficient against HIV infection. Isentress 400mg (Raltegravir 400mg) tablets are pharmacologically classified as an inhibitor of integrase. Isentress 400mg (Raltegravir 400mg) may used in Co-administration with other anti-retroviral drugs for producing beneficial activity. Isentress 400mg (Raltegravir 400mg) tablets are prescription regimen, which is used only under guidance of medical practitioner.

INDICATIONS of  Isentress 400mg (Raltegravir 400mg)

Isentress 400mg (Raltegravir 400mg) tablets are indicated to treat of HIV-1 infection by concomitant use with other anti-retroviral medicines. Hence the evidence is based on investigating the plasma HIV-1 RNA levels. The usage of Isentress 400mg (Raltegravir 400mg) is based on evalution of safety, tolerability, pharmacokinetic parameters & efficacy of Raltegravir.

MECHANISM OF ACTION  of  Isentress 400mg (Raltegravir 400mg)

Isentress 400mg (Raltegravir 400mg) consist of Raltegravir targeted the integrase which is an enzyme that assimilate the viral genetic material into human chromosome, a demanding step in HIV pathogenesis.

Absorption of Isentress 400mg (Raltegravir 400mg)

High plasma concentration time is almost 3 hours.

Distribution of Isentress 400mg (Raltegravir 400mg)
Raltegravir is largely bound to human serum protein by 83%. The drug is dispersed in red blood cells at minor range.

Metabolism of Isentress 400mg (Raltegravir 400mg)
Majorly in liver metabolism of Isentress 400mg (Raltegravir 400mg) is occurs

Elimination of Isentress 400mg (Raltegravir 400mg)
The Raltegravir excretion route is occurs through feces & urine. The Raltegravir half life period is 9 hours.

 SIDE EFFECTS  of  Isentress 400mg (Raltegravir 400mg)

While using with drug most people affect with some side effect. Some of them are listed below :
Decreased in platelets count Elevation of blood glucose level Increased bilirubin Increased serum AST, ALT Increased alkaline phosphatase Insomnia Abnormal dreams Fatigue Neutropenia Anemia Headache Nausea Asthenia Abdominal pain Gastritis Hepatitis Hypersensitivity Stevens Johnson syndrome Herpes zoster Dizziness Renal failure Suicidal ideation Rash

PRECAUTION  of  Isentress 400mg (Raltegravir 400mg)

Immune reconstitution syndrome: This lethal condition is generally occurred in patients who are receiving anti-retroviral treatment. Give safety measures In severe condition, stop the treatment. Phenylketonurics: Raltegravir is a chewable medication which consist of a component like phenylalanine (aspartame component) which is responsible for this fatal case. Severe skin reactions & anaphylactic reactions: Skin reactions like Stevens Johnson syndrome & toxic epidermal necrolysis are some of fatal cases occur. Provided life threatening condition, therapy should be discontinue and provide the general supportive therapy. Clinical wise status should be suitably monitored for decreasing the manifestations.

DRUG INTERACTION  of  Isentress 400mg (Raltegravir 400mg)

Interaction with atazanavir causes increasing the concentration of Raltegravir. The drug Raltegravir is not prevents the CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 or 3A. Raltegravir not prevents the P-gp mediated transport. Isentress 400mg (Raltegravir 400mg) tablets are interaction with rifampin leads to depletion of plasma concentration of Raltegravir. In case of this consolidation, the dose of Isentress 400mg (Raltegravir 400mg) should be increased for lowering this adverse problem. Interaction of Isentress 400mg (Raltegravir 400mg) with atazanavir/ritonavir, causes increasing concentration of Raltegravir Concurrently use of Isentress 400mg (Raltegravir 400mg) tablets with Efavirenz leads to cause decreasing the concentration of Raltegravir. Interaction of Isentress 400mg (Raltegravir 400mg) tablets with tipranavir/ritonavir, causes deminish the effect of concentration of Raltegravir. Co administration with gastric regulators should be avoided, because this combination leads to increase the effect of concentration of Raltegravir.

OVERDOSAGE  of  Isentress 400mg (Raltegravir 400mg)

The highest dose of Isentress 400mg (Raltegravir 400mg) is 1600mg as a single dose The highest dose of Isentress 400mg (Raltegravir 400mg) is 800mg as two times a day. Even if over dosage of Isentress 400mg (Raltegravir 400mg) occur patient must be; Start with supportive measures and excrete the unabsorbed dose from GI tract. Monitor the manifestation occurs due to over dosage

PREGNANCY & LACTATION  of Isentress 400mg (Raltegravir 400mg)

Category C: In Animal reproduction studies have shown adverse effect on fetus while in human there is no adequate and well controlled studies, but probable use may warrant the drug in pregnant women produce possible risk.

Breastfeeding is not recommended while using this drug


DOSAGE of  Isentress 400mg (Raltegravir 400mg)


Isentress 400mg (Raltegravir 400mg)  tablet should be taken with or without food. Isentress 400mg (Raltegravir 400mg) tablet should be taken with or without food. In adult, the usual dose is 400mg of Isentress 400mg (Raltegravir 400mg) should be given as a two times a day. In pediatrics; 12 years or older: The usual dose is 400mg of Isentress 400mg (Raltegravir 400mg) should be consumed as two times a day. 6 to less than 12 years of age: At least 25kg: One tablet of Isentress 400mg (Raltegravir 400mg) 400mg should be taken orally administer as two times a day ≥ 40kg: the drug Isentress 400mg (Raltegravir 400mg) 400mg should be administered two times a day.

STORAGE  of  Isentress 400mg (Raltegravir 400mg)

The drug should be kept at 20℃ to 25℃

Protect from light

Keep in dry & cool place

MISSED DOSE of  Isentress 400mg (Raltegravir 400mg)

Isentress 400mg (Raltegravir 400mg) is an anti-retroviral medicine, On condition of missed dose, the patient should be consult with medical practitioner and maintain the guidance Or skip missed dose and Maintain the regular dosing schedule

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