Leuben 100mg (Bendamustine)

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Hetero Drugs Ltd

Leuben 100mg (Bendamustine)

ManufacturerHetero Drugs LtdBrand nameLeubenInternational trade nameBendeka, Treanda, BelrapzoActive substanceBendamustineStrength100mgCategoryAnti Cancer

Description of Leuben 100mg (Bendamustine 100mg)

Bendamustine belongs to bifunctional mechlorethamine derivative accomplished of forming electrophilic alkyl groups which covalently bond to other molecules. Over this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death.

It is active against both active and quiescent cells, even though the exact mechanism of action is unknown.

Leuben 100mg (Bendamustine 100mg)  is a prescription medicine which is used under the guidance of medical supervision

Medical use /Indication of Leuben 100mg (Bendamustine 100mg)

Leuben 100mg (Bendamustine 100mg) is used for the treatment for Chronic lymphocytic Leukaemia in patients. Leuben 100mg (Bendamustine 100mg) is used for the treatment for Indolent B-cell non-Hodgkin’s lymphoma in patients

Mechanism of Action Leuben 100mg (Bendamustine 100mg)

Bendamustine belongs to alkylating agent, a chemical which can be internalized by cell and cause abnormal bonds between strands of DNA. This is an irreversible process whichinhibits the cell from replicating and causes the affected cell to die.

Bendamustine works in both cancerous and healthy cells.

Absorption of Leuben 100mg (Bendamustine 100mg)

Time to peak plasma: At end of infusion, Protein bound: 94-96%

Distribution of Leuben 100mg (Bendamustine 100mg)

Volume of distribution: 25L

Metabolism of Leuben 100mg (Bendamustine 100mg)

Metabolized by CYP1A2

Excretion of Leuben 100mg (Bendamustine 100mg)

feces 90%; Urine 1-10%
Half-life: 40min

Side effects of Leuben 100mg (Bendamustine 100mg)

Common side effects :

  • Nausea
  • Vomiting
  • Fatigue
  • Diarrhae
  • Rash
  • Decreased blood counts
  • Infusion reaction
  • Fever.

Some rare side effects :

  • Infertility.

Precautions of Leuben 100mg (Bendamustine 100mg)

Serious infusion and anaphylactic reactions resulted; check clinically and stopstreatment; premeditate in consecutive cycles for milder reactions
While on treatment will causes tumor lysis syndrome occurs; acute renal failure and death may reported; anticipate and use supportive measures
Probably of anaphylactic/infusion reactions: serious in rare cases
Myelosuppression may report; decrease dose; restart treatment based on ANC and platelet count recovery; difficult situation of myelosuppression may lead to death
Check further fever and other signs of infection and treat promptly.

Drug interaction of Leuben 100mg (Bendamustine 100mg)

Leuben 100mg (Bendamustine 100mg)  co administration with CYP1A2 inhibitors will have probably to increase plasma concentration of bendamustine and decrease plasma concentration of active metabolites.

Leuben 100mg (Bendamustine 100mg)  co administration with CYP1A2 inducers will have probably to decrease plasma concentration of bendamustine and increase plasma concentration of active metabolites.

Contraindication of Leuben 100mg (Bendamustine 100mg)

Known hypersensitivity to bendamustine and its metabolites

Pregnancy of Leuben 100mg (Bendamustine 100mg)

Pregnancy category is D

Based on adverse reaction, there is a positive symptom of human fetal risk

Do not use Leuben 100mg (Bendamustine 100mg)  during pregnancy.

Lactation of Leuben 100mg (Bendamustine 100mg)

The medicine excreted into human milk is unknown and effects in the new born baby are unknown
Hence use is contraindicated.

Dosage of Leuben 100mg (Bendamustine 100mg)

For chronic lymphocytic Leukaemia: The usual dose is 100mg/m2 IV infusion on days 1 and 2 of 28-day cycle, repeated for up to 6 cycles
Non-Hodgkin Lymphoma: Theusual dose is 120mg/m2 IV infusion on days 1 and 2 of 21-day cycle repeated for up to 8 cycles

Storage of Leuben 100mg (Bendamustine 100mg)

Store in refrigerator at 2℃ to 8℃ keep in original containers until time of use.

Missed dose of Leuben 100mg (Bendamustine 100mg)

If dose is missed, then have immediately before the reaching of next dose time or swap the missed dose and continue regular schedule. Consult the doctors for more information

Brand name:
International trade name:
Bendeka, Treanda, Belrapzo
Active substance:
Anti Cancer
Hetero Healthcare Ltd
1 Vial
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