Lindoshil 10mg (Lenalidomide)

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Brand nameLindoshilActive substanceLenalidomideStrength10mgCategoryAnti CancerManufacturerShilpa Medicare Ltd

Description  of  Lindoshil 10mg (Lenalidomide 10mg)

The indications of Lindoshil 10mg (Lenalidomide 10mg) are; Lindoshil 10mg (Lenalidomide 10mg) combination with dexamethasone is indicated to treat the patients suffered from multiple myeloma, the main ingredient which is used as Lenalidomide. Lindoshil 10mg (Lenalidomide 10mg) is indicated for the patients having transfusion-dependent anemia because of intermediate 1 risk myelodysplastic syndrome along with deletion 5q cytogenetic abnormality without or without addition cytogenetic abnormalities Lindoshil 10mg (Lenalidomide 10mg) is used to treat the patients with mantle cell lymphoma in which its used whose the disease was relapsed or progressed after two before treatment, especially the disease not response with the bortezomib therapy.

MECHANISM OF ACTION  of  Lindoshil 10mg (Lenalidomide 10mg)

Lindoshil 10mg (Lenalidomide 10mg) involves in the prudence of tumor and factor alpha arrangement, thatreinforcement the T-cells and leads to lessening plasma levels of cytokines vascular endothelial growth factor and fundamental fibroblast growth factor. Lindoshil 10mg (Lenalidomide 10mg) is moreover engaged with the stave off angiogenesis. Lenalidomide is further more authorize G1 cell cycle capture and apoptosis of ruinous cells.

ABSORPTION OF ACTION  of  Lindoshil 10mg (Lenalidomide 10mg)

absorbed rapidly with peak plasma concentration is between 0.625 and 1.5 hrs. combining with food will not change the prolong of absorption but dose decrease in C max.

DISTRIBUTION OF ACTION  of  Lindoshil 10mg (Lenalidomide 10mg)

bounding of plasma protein is 30%

METABOLISM OF ACTION  of  Lindoshil 10mg (Lenalidomide 10mg)

mainly metabolized in two metabolites is hydroxy-lenalidomide and N-acetyl-lenalidomide.

ELIMINATION OF ACTION  of  Lindoshil 10mg (Lenalidomide 10mg)

primarily eliminated in renal route and the dose excreted via urine 90% and feces 4% and half-life is 3hrs

 SIDE EFFECTS  of  Lindoshil 10mg (Lenalidomide 10mg)

Second primary malignancies Hepatotoxicity , Hypersensitivity reactions, Thyroid dysfunction, Fetal toxicity, Hematological toxicity, Tumor lysis syndrome, Tumor flare reactions, Increase of mortality rate.
Common side effects;
Diabetes mellitus, Rash, Insomnia, Depression, Deep vein thrombosis, Myocardial infraction, Renal failure, Squamous cell carcinoma, Basal cell carcinoma, Fatigue, Asthenia, Pyrexia, Pain, Diarrhea, Dyspepsia, Bone pain, Neck pain, Respiratory infections, UTI, Influenza, Sepsis, Headache, Anemia, Loss of appetite, Hypokalemia, Hyperglycemia, Hypocalcaemia, Dehydration, Gout.

PRECAUTION  of  Lindoshil 10mg (Lenalidomide 10mg)

The some of the common life-threatening condition like
Venous & arterial thromboembolism
Blood clotting effects
Embryo fetal damage
Hypersensitivity reactions
Hematological disorders
For all these conditions, some supportive measures should be used and provide safety measures.

DRUG INTERACTION  of  Lindoshil 10mg (Lenalidomide 10mg)

Interaction of Lindoshil 10mg (Lenalidomide 10mg)  with digoxin leads to increased concentration of digoxin causes increased risk of adverse effects related to digoxin. Interaction of Lindoshil 10mg (Lenalidomide 10mg) with Erythropoietic agents, cause to produced rises in risk of thrombosis. Discuss with the patients prior to starting this combination treatment. Interaction of Lindoshil 10mg (Lenalidomide 10mg) with warfarin, will produce increased exposure of hemorrhage disorders. check the INR value & prothrombin time.

OVERDOSAGE  of  Lindoshil 10mg (Lenalidomide 10mg)

Over dosage of Lindoshil 10mg (Lenalidomide 10mg) will cause neutropenia& thrombocytopenia as mainly common side effects. Give the patient general supportive treatment. check the blood cells counts regularily during the treatment.

CONTRAINDICATION of  Lindoshil 10mg (Lenalidomide 10mg)

When pregnancy period the drug is contraindicated The patients are contraindicated to hypersensitivity reaction and the Lindoshil 10mg (Lenalidomide 10mg) component.

PREGNANCY  of Lindoshil 10mg (Lenalidomide 10mg)

Pregnancy category X Lindoshil 10mg (Lenalidomide 10mg) will produce serious fetal damage leads to death

LACTATION  of Lindoshil 10mg (Lenalidomide 10mg)

While on Lindoshil 10mg (Lenalidomide 10mg) treatment ,Breast feeding should not be recommended

DOSAGE of  Lindoshil 10mg (Lenalidomide 10mg)

The adult usual dose of Lindoshil 10mg (Lenalidomide 10mg) in myelodysplastic syndromes is 10mg and adminisrated once a day. For renal damaged patients; CrCl>60ml/minIn Patients should not needed dosage adjustment of Lindoshil 10mg (Lenalidomide 10mg) CrCl 30 to 60ml/minIn Patients, 5mg of Lindoshil 10mg (Lenalidomide 10mg)  should administre orally as once daily CrCl<30ml/minIn Patient, 2.5mg of Lindoshil 10mg (Lenalidomide 10mg)should be given orally as a once daily. Dosage variation;
Drops to <50000/mcL, treatment should be interrupted. Back to > or equal to 50000/mcL, follow the Lindoshil 10mg (Lenalidomide 10mg) of 5mg per day.
Drops to <500/mcL, treatment should be delayed. Back to > or equal to 500/mcL, treatment should be follow to 5mg per day.
Multiple myeloma
In this disease, concomitant use of dexamethasone with Lindoshil 10mg (Lenalidomide 10mg). The regular dose of Lindoshil 10mg (Lenalidomide 10mg) is 25mg should be given as once in a day on day 1 to 21. The dose of dexamethasone; Dexamethasone 40mg should be continued on day 1 to 4, 9 to 12 & 17 to 20 of each period of28-day cycles. Patient with greater than 75 years, dexamethasone20mg should be prescribed on day 1, 8, 15, & 22.

STORAGE  of  Lindoshil 10mg (Lenalidomide 10mg)

The drug stored at 20℃ to 25℃. Store the container from light Protect away from moisture & heat.

MISSED DOSE of  Lindoshil 10mg (Lenalidomide 10mg)

if a single dose is missed, have the drug probably soon Next dose time reaches then leave the missed dose and continue the regular schedule Please consult with the doctor.

Brand name:
Active substance:
Anti Cancer
Shilpa Medicare Ltd
10 Capsules
Product form:

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