Mofilet-S 360mg - Description , Uses , Prices , Side effects.

Mofilet-S 360mg (Mycophenolate Mofetil)

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composition: Mycophenolate Mofetil

Mofilet-S 360mg (Mycophenolate Mofetil)

ManufacturerEmcure Pharmaceuticals LtdBrand nameMofilet-SActive substanceMycophenolate MofetilStrength360mgCategoryNephrologyManufacturerEmcure Pharmaceuticals Ltd

Description of Mofilet-S 360mg (Mycophenolate Mofetil 360mg)

Mycophenolic acid is belonging to immunosuppressive medicine.
Mofilet-S 360mg (Mycophenolate Mofetil 360mg) is an inactive form of mycophenolic acid (MPA). Following oral administration, Mofilet-S 360mg (Mycophenolate Mofetil 360mg) is fastly absorbed and hydrolysedchange into MPA.
MPA is the effective metabolite which has pharmacological action.
Mofilet-S 360mg (Mycophenolate Mofetil 360mg) which is used as prescription medicine provided under the guidance of doctors.

Medical use /Indication of Mofilet-S 360mg (Mycophenolate Mofetil 360mg)

Mofilet-S 360mg (Mycophenolate Mofetil 360mg) is an immunosuppressant medicine which is prescribed for the prophylaxis of organ refusal in patients getting allogeneic renal, cardiac or hepatic transplants.

Mechanism of Action Mofilet-S 360mg (Mycophenolate Mofetil 360mg)

Mycophenolate Mofetil consist ofmorpholino ethyl ester of mycophenolic acid (MPA) with effective immunosuppressive properties mycophenolic blocks T-cell and B-cell multiplicationvia selective prohibition of the de novo pathway of purine biosynthesis. In vivo, the effective metabolite, MPA, reversibly prevents inosine 5’-monophosphate dehydrogenase, an enzyme contains in the de novo synthesis of guanine nucleotides. MPA show high lymphocyte specificity and cytotoxicity because of higher dependence of stimulation lymphocytes on both salvage and de novo synthesis of guanine nucleotides relative to other cell types. (NCI04)

ADME of Mofilet-S 360mg (Mycophenolate Mofetil 360mg)

Rapidly absorbed and bioavailability are 94% for oral Mycophenolate mofetil

the active metabolite MPA bounded to plasma protein is 98%.

Primarily metabolised by glucuronic transferase to form inactive phenolic glucuronide of MPA.

Mofilet-S 360mg (Mycophenolate Mofetil 360mg) is totally recovered with 93% dose in urine and 6% via feces and 87% administrated dose eliminated via urine as MPAG

Half-life of Mofilet-S 360mg (Mycophenolate Mofetil 360mg) is 13-17 hours

Side effects of Mofilet-S 360mg (Mycophenolate Mofetil 360mg)

Mofilet-S 360mg (Mycophenolate Mofetil 360mg) Common side effects :

Diarrhoea
Vomiting
Pain
Abdominal pain
Hypertension
Swelling of the ankles or feet, lower legs.

Serious side effects :

Infection
Infection in blood
Pharyngitis
Low RBC, and WBC

Precautions of Mofilet-S 360mg (Mycophenolate Mofetil 360mg)

Embryofoetal Toxicity Mofilet-S 360mg (Mycophenolate Mofetil 360mg) can leads fetal harm when given to a pregnant female. While Use of Mofilet-S 360mg (Mycophenolate Mofetil 360mg) during pregnancy is along with an high risk of first trimester pregnancy loss and increased risk of congenital malformations

Lymphoma and Malignancy :

When Patients getting immunosuppressive medicine including co administration of medicines, contains Mofilet-S 360mg (Mycophenolate
Mofetil 360mg), as part of an immunosuppressive regimen have increase of developing lymphomas and other malignancies, especially effect the skin

Pregnancy Exposure Prevention and Planning :

Females of reproductive possible should be made aware of the high risk of lack of first trimester pregnancy and congenital malformations and must be advise about pregnancy stopping and planning.

Drug interaction of Mofilet-S 360mg (Mycophenolate Mofetil 360mg)

Concomitant use of Mofilet-S 360mg (Mycophenolate Mofetil 360mg) with acyclovir or ganciclovir may causes high blood levels
Mofilet-S 360mg (Mycophenolate Mofetil 360mg) and interacting medicines elimination through kidneys the medicines complete with each other
Mofilet-S 360mg (Mycophenolate Mofetil 360mg) concomitant use with antacid may reduce MPA blood levels
Combination with proton pump may reduce blood levels by binding in the intestine.
Mofilet-S 360mg (Mycophenolate Mofetil 360mg) concomitant use with birth control pills may reduce the effectiveness of some oral contraceptives

Contraindication of Mofilet-S 360mg (Mycophenolate Mofetil 360mg)

Mofilet-S 360mg (Mycophenolate Mofetil 360mg) is contraindicated to the patients having with;

Hypersensitivity to mycophenolate mofetil

Allergic to polysorbate 80 (tween)
Pregnant women
Breastfeeding women

Pregnancy of Mofilet-S 360mg (Mycophenolate Mofetil 360mg)

Pregnancy category D

When use of Mofilet-S 360mg (Mycophenolate Mofetil 360mg) during pregnancy will have high risk of 1st trimester loss and congenital malformations occurred.

Lactation of Mofilet-S 360mg (Mycophenolate Mofetil 360mg)

Do not use Mofilet-S 360mg (Mycophenolate Mofetil 360mg) during breast feeding to infants.

Dosage of Mofilet-S 360mg (Mycophenolate Mofetil 360mg)

Mofilet-S 360mg (Mycophenolate Mofetil 360mg) is primarily necessary for inhibition of organ transplant of kidney, heart and liver, the dosage as follows

Kidney transplantation :

For Adult the recommended dose for kidney transplantation is 1 g given orally or intravenously (over no less than 2 hours) twice a day.
For pediatric (3 months to 18 years of age) the recommended dose of the oral suspension is 600 mg/m2 given twice daily (maximum daily dose of 2 g/10 ml).
Dosage also calculated according to body surface area
Capsule dose of 750 mg twice daily administers to Patients with a body surface area of 1.25 m2 to 1.5 m2.
Capsules or tablets at a 1 g dose twice daily is administrated to Patients with a body surface area >1.5 m2.

Heart transplantation :

For Adults the prescribed dose for heart transplantation is 1.5 g given twice daily intravenously over no less than 2 hours or 1.5 g administrated orally twice daily.

Liver Transplantation :

For Adults the prescribed dose for Liver Transplantation is 1 g twice daily given via intravenously over no less than 2 hours or 1.5 g orally twice daily.
For Geriatrics (elderly patients) the recommended orally is 1 g dose twice daily for renal transplant patients, 1.5 g dose given twice daily for heart transplant patients, and 1 g dose twice in a day administered intravenously or 1.5 g dose twice in a day given orally in liver transplant patients.