Myhep DVIR (Sofosbuvir and Daclatasvir )

Sofosbuvir and Daclatasvir
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Mylan

Myhep DVIR (Sofosbuvir and Daclatasvir )

ManufacturerMylanBrand nameMyhep DVIRInternational trade nameSovodakActive substanceSofosbuvir and Daclatasvir Strength400mg & 60mg CategoryHepatitis C

Description of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg)

Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) tablets are hostile to viral medicine Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) tablets are single measurements treatment, it is a doctor prescribed medication utilized by the patients just under the information of restorative expert who are all around rehearsed Daclatasvir isn't utilized alone, for better activity it ought to be joined with Sofosbuvir tablet. In some condition Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) is joined with ribavirin, a hostile to viral pharmaceutical utilized as a part of decompensated (Child Pugh B or C) cirrhosis

Medical use /Indication of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg)

The primary sign of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) is; This mix tablets are utilized to treat the constant hepatitis C viral disease caused by genotype I or III The significant restriction happened while utilizing Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) tablets are lessening of steady virological reaction rate in hepatitis C genotype I or III contaminated patients.

Mechanism of Action Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg)

The activity of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) tablets are occurred by involving in some mechanism;

Sofosbuvir

Sofosbuvir containing sofosbuvir has hostile to hepaciviral movement, which is specifically acting medication displays its activity by disallowing NS5B RNA dependent RNA polymerase protein; fundamental for hepatitis viral duplication. Sofosbuvir is processed to frame uridine triphosphate, a fundamental dynamic metabolite which uncovered a hostile to viral action. The mixture of this dynamic metabolite into hepatitis viral RNA with the assistance of NS5B polymerase and causes viral chain cessation

Daclatasvir

Daclatasvir containing Daclatasvir removes hostile to viral action by restricting NS5A protein which is needful in viral generation and virion collection

Side effects of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg)

The most common side effects occurred during the therapy;
Headache, Loss of appetite, Irritability, Neutropenia, Anemia, Chills, Influenza like symptoms, Pyrexia, Myalgia, Pancytopenia, Fatigue, Nausea, Diarrhea, Elevation of lipase, Cardiac problems like symptomatic bradycardia , Insomnia, Pruritus, Asthenia, Rashes, on the grounds that almost 99% of medication limited to human plasma protein . 

Drug interaction of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg)

While consolidating Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) with solid CYP3A inducers causes loss of virological response rate of Daclatasvir CYP3A solid inducers like st Johns wort, rifampin, phenytoin or carbamazepine In the event that Sofosbuvir joins with P-gp or BCRP inhibitors prompts cause rise of Sofosbuvir plasma focus. Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) tablets attendant with amiodarone causes genuine symptomatic bradycardia. Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) tablets attendant with hostile to convulsants, against mycobacterials or natural items like st Johns wort causes diminish as a result of fixation Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) with HMG CoA reductase inhibitors, this mix prompts because expanding the presentation of these medications (statins)

Precaution of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg)

While taking Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) tablets, with CYP3A solid inducers causes loss of remedial reaction of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) tablets. Stay away from this accompanying to diminish the unfriendly impacts Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) causes genuine bradycardia while simultaneous use with amiodarone, to keep this condition some elective solution is given or ends the amiodarone if conceivable. Insight the patients about the introduction of bradycardia amid the treatment Utilizing Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) with ribavirin, ought not be prescribed in pregnancy condition as a result of creating fetal harm because of ribavirin

Over dosage of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg)

The over dose of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) tablets are happened because of missed measurement , if once finished dose happens the patients must be observed oftentimes for support of harmfulness and give wellbeing measures Hemodialysis is a technique used to take out the part from body, sofosbuvir evacuates with partition coefficient of 54% though Daclatasvir is hazardous

Contraindication of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg)

A few contraindications happens while utilizing Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) tablets In decompensated cirrhosis, joins with ribavirin contraindicated in pregnancy condition Some anaphylactic response happens if patients are contraindicated to the segments show in Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg)

Pregnancy & Lactation of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg)

Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) use in pregnancy, considered as effective. The pregnancy category is B1 While concomitant with ribavirin, not suggested for pregnancy Pregnancy category: X, causes fetal harm Breast feeding should not be recommended

Dosage of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg)

Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) tablets are given with or without food, in the condition of chronic hepatitis C viral infection originated by genotype I or III Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) is single dose therapy

Dosage regimens

Daclatasvir normally is not used alone treatment, it is combined with Sofosbuvir The suggested dosage of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) is one tablet should be taken as a single dose If Sofosbuvir is discontinued, Daclatasvir also get stopped Genotype I Patient suffered without cirrhosis or with compensated cirrhosis: The recommended usual dosage of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) is one tablet should be taken as a single dose with or without food In decompensated cirrhosis patients: Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) should be altogether with ribavirin as a single dose

Genotype III

Patient suffered without cirrhosis or with compensated cirrhosis: The recommended usual dosage of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) is one tablet should be administered as a single dose with or without food In decompensated cirrhosis patients: Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) should be concomitant with ribavirin as a once a day The dosage of ribavirin; The hemoglobin level of patients, dose can be calculated on basis of body weight. Below 75kg: The dosage is 1000mg of ribavirin; suggested for genotype I or III 600mg of ribavirin as an primary dose and followed as 1000mg/per Slightly 75 kg: The dose of 1200mg of ribavirin administrated In decompensated cirrhosis given as twice daily. The safety and efficacy of Daclatasvir has not been established <18 years Sofosbuvir used in ≥12 years or weight of ≥35kg

Storage of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg)

The storage condition of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) should be stored at room temperature below 30℃ (86℉) & 20℃and 25℃ (68℃ and 77℉) respectively Container should be keep away from heat, light and moisture

Missed dose of Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg)

Both Myhep DVIR (Sofosbuvir 400mg & Daclatasvir 60mg) tablets are single dosage treatment, if tolerant neglects to take the measurement of these tablets, must counsel the doctor and take the measurement inside the time according to the direction given by therapeutic expert Generally the missed measurement ought to be skipped and take after the standard dosing plan

Brand name:
Myhep DVIR
International trade name:
Sovodak
Active substance:
Sofosbuvir and Daclatasvir
Strength:
400mg & 60mg
Category:
Hepatitis C
Manufacturer:
Mylan
Packaging:
28 Tablets
Product form:
Tablet

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