Nelvir 250mg (Nelfinavir)

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Cipla Ltd

Nelvir 250mg (Nelfinavir)

ManufacturerCipla LtdBrand nameNelvirInternational trade nameViraceptActive substanceNelfinavirStrength250mgCategoryHIV

Description of Nelvir 250mg (Nelfinavir 250mg)

Nelvir 250mg (Nelfinavir 250mg) is type of HIV-1 protease inhibitor and includes in group of anti-retroviral drugs. Nelvir 250mg (Nelfinavir 250mg) needed for inhibition of HIV from reproducing in your body. The drug also required to treat a virus which cause acquired immunodeficiency syndrome. Nelvir 250mg (Nelfinavir 250mg) is not cure for HIV or AIDS. Nelvir 250mg (Nelfinavir 250mg) is prescription drug which is used under supervision of medical practioners.

Medical use /Indication of  Nelvir 250mg (Nelfinavir 250mg)

Nelvir 250mg (Nelfinavir 250mg) is used to treat patients affected by HIV-1 infection with combination of other antiretroviral drugs.

Mechanism of action  Nelvir 250mg (Nelfinavir 250mg)

Nelvir 250mg (Nelfinavir 250mg) which will join to the site of HIV-1 protease activity and inhibits cleavage of viral Gag-Pol polyprotein precursors into divide the functional proteins necessary for infectious HIV. This will causes to immature formation, noninfectious viral particles.

Absorption of  Nelvir 250mg (Nelfinavir 250mg)

AUC of Nelvir 250mg (Nelfinavir 250mg) is highly variable in pediatric patients because increased clearance, problems with compliance and inconsistent food intake with dosing. The time to high plasma concentration is 2 to 4 hours.

Distribution of  Nelvir 250mg (Nelfinavir 250mg)

Volume of distribution is 2 to 7 L/kg

Metabolism of  Nelvir 250mg (Nelfinavir 250mg)

Mainly metabolized through Hepatic via CYP2C19 and 3A4

Excretions of  Nelvir 250mg (Nelfinavir 250mg) 

The elimination of drug through feces 98% to 99% and as metabolite 78% and unchanged drug as 22% and through urine 1% to 2%.

Side effects of Nelvir 250mg (Nelfinavir 250mg)

Side effects by Clinical trials experience- adult and adolescents (13 yrs and older) Hemic/lymphatic system: anemia, leucopenia and thrombocytopenia Metabolic/nutritional: liver function test abnormalities amylase, SGOT, SGPT, hypoglycemia, dehydration Digestive system: diarrhea, nausea, flatulence, epigastric pain Skin /appendages: rash Musculoskeletal system: arthralgia, arthritis, cramps,myalgia Respiratory: dyspnae, pharyngitis, rhinitis, and sinusitis. Special sense: acute iritis and eye disorder.

Qtc prolongation Jaundice Hypersensitivity reaction Bilirubinemia, metabolic acidosis.

Drug interaction of  Nelvir 250mg (Nelfinavir 250mg)

Concomitant use with antacids, Phenobarbital, carbamazepine, aminoglutethimide, phenytoin, rifampicin, nafcillin, nevirapine, omeprazole will reduce the levels of nevimune Interaction of Nelvir 250mg (Nelfinavir 250mg) with antifungal agents, cimetidine, Efavirenz wills increases serum levels. Reduced plasma effects while concomitant use with hormonal contraceptives, methadone, theophylline derivatives

Over dosage of  Nelvir 250mg (Nelfinavir 250mg)

The highest dose of Nelvir 250mg (Nelfinavir 250mg) is 1600mg as a single dose The highest dose of Nelvir 250mg (Nelfinavir 250mg) is 800mg as two times a day. Even if over dosage of Nelvir 250mg (Nelfinavir 250mg) occur patient must be; Start with supportive measures and excrete the unabsorbed dose from GI tract. Monitor the manifestation occurs due to over dosage

Precaution of  Nelvir 250mg (Nelfinavir 250mg)

If patients have Diabetes mellitus/hyperglycemia. Inform the doctor before taking treatment with Nelvir 250mg (Nelfinavir 250mg) Hemophilia: increased bleeding level with nelfinavir treatment Fat distribution Risk of serious adverse reaction due to drug interaction Hepatic impairment: the drug should not be used Phenylketourics ; nelfinavir contains phenylalanine which is harmful to patients with phenylketouria. Immune Reconstitution Syndrome 

Contraindication of  Nelvir 250mg (Nelfinavir 250mg)

Nelfinavir combination with CYP3A for clearance is contraindicated

Dosage of  Nelvir 250mg (Nelfinavir 250mg)

For adult the usual dose for HIV infections in patients administered as 1250 mg given orally twice a day or 750mg given orally 3 times a day The drug administer in combination with other antiretroviral agents for treatment of HIV-1 Infection. For Non occupational Exposure the dose US CDC prescribed as 1250mg two times a day orally or 750mg three times a day orally given for 28 days. For pediatric dose age 2 to less than 13 years prescribed dose is 45 to 55 mg/kg given orally twice a day Or 25 to 35 mg/kg given orally three times a day. Maximum dose is 2500mg/day. Age 13 years or older = 1250mg given orally twice times a day or 750mg taken orally three times a day. The children weighing 16 kg or more administer 250mg for twice-daily

Storage of  Nelvir 250mg (Nelfinavir 250mg)

Store at 15℃ to 30℃

Store the container closed tightly

Dispense in original container

Missed dose of  Nelvir 250mg (Nelfinavir 250mg)

If patients missed a dose then have the drug while you remember before next dose timing or skip the missed dose and follow regular schedule Please consult with the doctor 

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