Penvir 250mg (Famciclovir)

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Hetero Drugs Ltd

Penvir 250mg (Famciclovir)

ManufacturerHetero Drugs LtdBrand namePenvirActive substanceFamciclovirStrength250mgCategoryAnti ViralManufacturerHetero Healthcare Ltd

Description of Penvir 250mg (Famciclovir 250mg)

Penvir 250mg (Famciclovir 250mg) belongs to antiviral medicines 

Penvir 250mg (Famciclovir 250mg) reduce the growth and spread of the herpes virus in which body can fight against infection.

No treatment for herpes and Penvir 250mg (Famciclovir 250mg) will not inhibits from growth of symptoms in the future.

Medical use /Indication of Penvir 250mg (Famciclovir 250mg)

  • Penvir 250mg (Famciclovir 250mg) used for the treatment or prevention of herpes infections
  • Penvir 250mg (Famciclovir 250mg) used for the treatment of cold sores
  • Penvir 250mg (Famciclovir 250mg) used for the treatment for shingles
  • Penvir 250mg (Famciclovir 250mg) used for the treatment of returning herpes simplex infections of the skin and mucus membranes (mouth, anus) in people with (HIV) infection.

Mechanism of Action Penvir 250mg (Famciclovir 250mg)

Famciclovir readily go through biotransformation to penciclovir, which has preventory activity against HSV types 1 (HSV-1) and 2 (HSV-2), varicella-zoster virus (VZV). Thymidine kinase then add phosphorus group to penciclovir to a monophosphate form, which is then converted to penciclovir triphosphate. This blocks HSV-2 DNA polymerase by competing with deoxyguanosine triphosphate, thus prohibiting herpes viral DNA synthesis and multiplication.

ADME of Penvir 250mg (Famciclovir 250mg)

Absorption of Penvir 250mg (Famciclovir 250mg)

Fastly absorbed from the GI tract. The Penvir 250mg (Famciclovir 250mg) has Bioavailability: 77% (penciclovir) and Time to peak plasma concentration 1 hr. Food may delay absorption.

Distribution of Penvir 250mg (Famciclovir 250mg)

Plasma protein binding of Penvir 250mg (Famciclovir 250mg)  is <20%.

Metabolism of Penvir 250mg (Famciclovir 250mg)

changed to penciclovir through deacetylation and oxidation.

Excretion of Penvir 250mg (Famciclovir 250mg)

Penvir 250mg (Famciclovir 250mg)  excreted through urine (73%); faces (27%). Elimination half-life of Penvir 250mg (Famciclovir 250mg): 1.6-3 hr.

Side effects of Penvir 250mg (Famciclovir 250mg)

Less common side effects of Penvir 250mg (Famciclovir 250mg)

  • Bloated, full feeling
  • Excess air or gas in the stomach or intestines
  • Redness of skin
  • Mood or mental changes
  • Hives or welts
  • Itching skin

More common side effects of Penvir 250mg (Famciclovir 250mg)

  • Heavy bleeding
  • Headache
  • Diarrhea
  • Cramps

Incident not known side effects of Penvir 250mg (Famciclovir 250mg)

  • Black stools
  • Bleeding gums
  • Blistering, peeling of the skin
  • Dizziness
  • Joint or muscle pain
  • Pinpoint red spots on the skin
  • Yellow eyes or skin
  • Sores, ulcers or white spot in the mouth or on the lips

Precautions of Penvir 250mg (Famciclovir 250mg)

  • Susceptible to famciclovir, penciclovir cream (Denavir), acyclovir (Zovirax), any other medications, or lactose. Consult your doctor
  • Consult your doctor if you had problems with your immune system, (HIV), (AIDS); inherited conditions where the body is not able to tolerate lactose; or kidney or liver disease.
  • Consult your doctor if you are pregnant, decide to become pregnant, or are breast-feeding. While taking Penvir 250mg (Famciclovir 250mg) treatment If you become pregnant, discuss with doctor about the condition.
  • Penvir 250mg (Famciclovir 250mg)  may produce drowsy, dizzy, confused, or disoriented. Avoid drive a car until reaction of medication you feel.

Drug interaction of Penvir 250mg (Famciclovir 250mg)

Interaction of Penvir 250mg (Famciclovir 250mg) with digoxin will slightly increase the digoxin in your blood.
Concomitant use of Famciclovir with probenecid will raise the level of Famciclovir in your blood and increase side effects.

Pregnancy of Penvir 250mg (Famciclovir 250mg)

Category B: In animal reproduction studies have not demonstrated a fetal risk but in human studies have no controlled studies carried out in the 1st trimester.

Lactation of Penvir 250mg (Famciclovir 250mg)

Excretion of famciclovir into human milk has no data. On the safety of penciclovir in nursing infants has no data available. The medicine should be avoided in breast feeding mother.

Dosage of Penvir 250mg (Famciclovir 250mg)

The recommended dose in Adult for tablet Famtrex

Herpes Simplex – Suppression

The usual dose is 250mg twice a day orally for Immunocompetent patients.

The usual dose is 500mg twice a day orally for HIV- Infected patients.

Herpes Zoster

Dose given 500mg every 8 hours for 7 days orally.

Herpes Simplex Labialis

Recurrent herpes labalis: 1500mg single dose orally.

Herpes Simplex – Mucocutaneous / immunocompetent Host

For 7 to 10 days 250mg administrated 3 times a day given orally.

Relapsed episodes: Given 1000mg twice a day for 1 day orally rather 125mg twice a day orally for 5 days.

Herpes Simplex – Mucocutaneous / immunocompromised Host

Relapsed episodes : 500mg twice a day for 7 days.

Over dosage of Penvir 250mg (Famciclovir 250mg)

Famtrex was well tolerated, If it occurs provide supportive and symptomatic treatment should be given as appropriately.

Storage of Penvir 250mg (Famciclovir 250mg)

Store the tablet in a closed container

Keep away from moisture, heat and direct light

Avoid freezing

Ask the pharmacist how to dispose the medicine left out.

Missed dose of Penvir 250mg (Famciclovir 250mg)

Immediately administer the medicine as you remember,If you missed any dose .If next dose time reaches swap the missed dose and continue the regular schedule. avoid taking double dose at a time. Please consult the doctor for further details.

Brand name:
Active substance:
Anti Viral
Hetero Healthcare Ltd
6 Tablets
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