Pirfenex 200mg (Pirfenedone)
Description of Pirfenex 200mg (Pirfenidone 200mg)
Tablet Pirfenex 200mg (Pirfenidone 200mg) is an effective medicine, but it causes some life threatening conditions. It causes an abnormal chromosomal structure, patient who are getting Tablet Pirfenex 200mg (Pirfenidone 200mg); exposing to light in genotoxicity tests. Patient must have knowledge about the potential of the medicine Pirfenex 200mg (Pirfenidone 200mg) which causes carcinogenesis in skin on exposed to light. Tablet Pirfenex 200mg (Pirfenidone 200mg) should be prescribed under the supervision of medical practitioner who is familiar with the idiopathic pulmonary fibrosis therapy. Tablet Pirfenex 200mg (Pirfenidone 200mg) is anti fibrotic agent involved in the treatment of idiopathic pulmonary fibrosis (lung disease).
Medical use /Indication of Pirfenex 200mg (Pirfenidone 200mg)
Pirfenex 200mg (Pirfenidone 200mg) tablet is primarily used in the condition of Idiopathic Pulmonary Fibrosis (IPF).
Mechanism of Action Pirfenex 200mg (Pirfenidone 200mg)
Pirfenex 200mg (Pirfenidone 200mg), the mechanism of action of the medicine is not completely established. Tablet Pirfenex 200mg (Pirfenidone 200mg) is an effective anti-fibrotic and anti inflammatory agent. Anti fibrotic activity of Pirfenex 200mg (Pirfenidone 200mg) is mainly taken into consideration. Pirfenex 200mg (Pirfenidone 200mg), number of cell based therapy takes place. It leads to reduce fibroblast proliferation, prohibits TGF-β accelerated collagen production, and decrease the synthesis of fibrogenic mediators like TGF-β (transforming growth factor). Pirfenex 200mg (Pirfenidone 200mg) has activity to reduce production of inflammatory mediators like TNF-α (tumor necrosis factor) and IL-1β (interleukin 1 beta).
ADME of Pirfenex 200mg (Pirfenidone 200mg)
Absorption of Pirfenex 200mg (Pirfenidone 200mg)
The absorption of medicine Pirfenidone is varying among the condition of the patient. In healthy persons, absorption occurs within 20-60mins. If tablet Pirfenex 200mg (Pirfenidone 200mg) taken with food somewhat decrease the absorption. But in older adults, tablet Pirfenex 200mg (Pirfenidone 200mg) is co administered with food leads to increase tolerability.
Distribution of Pirfenex 200mg (Pirfenidone 200mg)
Tablet Pirfenex 200mg (Pirfenidone 200mg) binds to plasma proteins, majorly with serum albumin. Within 1-3 hours of administration, protein binding was 54-62%.
Metabolism of Pirfenex 200mg (Pirfenidone 200mg)
Medicine Pirfenidone is metabolized by liver. Approximately 48% of medicine eis metabolized via CYP1A2 with other CYP isoenzymes. The major metabolite is 5-carboxy-pirfenidone.
Excretion of Pirfenex 200mg (Pirfenidone 200mg)
The elimination half life is around 2.4 hours. About 80% of the metabolites cleared in urine within 24 hours. Tablet Pirfenex 200mg (Pirfenidone 200mg) after administration, excreted as major metabolite 5-carboxy-pirfenidone (95%), with less than 1% of medicine Pirfenidone excreted consistent as well in the urine. Plasma concentration of the tablet Pirfenex 200mg (Pirfenidone 200mg) (with or without meals), because of food C¬¬max and AUC decreased, Tmax is significantly delayed.
Side effects of Pirfenex 200mg (Pirfenidone 200mg)
Most common side effects caused by Pirfenex 200mg (Pirfenidone 200mg) include :
Photosensitivity reactions like rashes, Loss of appetite, Stomach discomfort, Nausea, Increased AST and ALT levels, Fatigue, Diarrhea, Dyspepsia. ADVERSE
REACTIONS :
Infections and infestation: upper respiratory tract infections, UTI
Blood & lymphatic system: agranulocytosis
Immune system: angioedema
Metabolism & nutrition: anorexia, weight decreased, loss of appetite
Psychiatric: insomnia
CNS: headache, dizziness, somnolence, dysgeusia, lethargy
Heart problems: hot flush
Pulmonary: dyspnea, cough
GIT: gastro esophageal reflux, vomiting, constipation, gastritis.
Hepatobiliary: ALT, AST increased, serum albumin increased.
Precautions of Pirfenex 200mg (Pirfenidone 200mg)
Pirfenex 200mg (Pirfenidone 200mg) tablets should be taken with caution; In the conditions like; While patient taking tablet Pirfenex 200mg (Pirfenidone 200mg), they may leads to, Elevation of liver enzymes Photosensitivity and rash Gastro intestinal disorder Consumption of grapefruit juice: leads to inhibit CYP1A2. It should be avoided during the treatment.
Drug interaction of Pirfenex 200mg (Pirfenidone 200mg)
Tablet Pirfenex 200mg (Pirfenidone 200mg) has some of drug interactions, which is propitiating by cytochrome enzymes :
Tablet Pirfenex 200mg (Pirfenidone 200mg) is metabolized through the CYP1A2 enzyme pathway. The various medicine which inhibits this cytochrome enzyme leads to accumulation of toxicity of Pirfenidone. Some of the CYP1A2 inhibitors medicines like Fluoxamine, ciprofloxacin, amiodarone etc. CYP inhibitors: these are strong inhibitors like paroxetine, fluconazole, and chloramphenicol
CYP1A2 inducers :
Omeprazole is used cautiously with tablet Pirfenex 200mg (Pirfenidone 200mg), might have chance to reduce the plasma level of the medicine Pirfenidone.
Cigarette smoking :
Smoking during the treatment with tablet Pirfenex 200mg (Pirfenidone 200mg) causes increased clearance of Pirfenidone.
Contraindication of Pirfenex 200mg (Pirfenidone 200mg)
Pirfenex 200mg (Pirfenidone 200mg) tablets are contraindicated to the patient having hypersensitivity to active ingredient Pirfenidone. Other conditions : Angioedema with Pirfenidone Adjuvant use of Fluoxamine Severe hepatic and renal impairment
Pregnancy & Lactation of Pirfenex 200mg (Pirfenidone 200mg)
Tablet Pirfenex 200mg (Pirfenidone 200mg) should be comes under pregnancy category C.
Nursing mothers who receive tablet Pirfenex 200mg (Pirfenidone 200mg) must advice to avoid breastfeeding.
Dosage of Pirfenex 200mg (Pirfenidone 200mg)
The recommended dose of tablet Pirfenex 200mg (Pirfenidone 200mg) in adolescent is 200mg for three times a day (TID), 600mg/day. Depending upon the severity of the condition (IPF), dosage may adjust up to 1800mg/day. Dosage of the tablet Pirfenex 200mg (Pirfenidone 200mg) depending up on symptom. Initially patient starts with 200mg TID, after 2 weeks, dose may gradually increase to 600mg at a time (1800mg/day).
Dose adjustment and other consideration for safe use :
Gastro intestinal events :
Patient, during therapy with tablet Pirfenex 200mg (Pirfenidone 200mg) may affected by gastrointestinal side effects, so patient advice by taking tablet Pirfenex 200mg (Pirfenidone 200mg) with food. If a symptom endures means, dose may reduce to 1-2 tablets given for 2-3 times a day with food. Photo sensitive reactions: If rashes sustains for 7 days, tablet Pirfenex 200mg (Pirfenidone 200mg) should be discontinued for 14 days. It is continued by the guidance of health care providers.
Storage of Pirfenex 200mg (Pirfenidone 200mg)
Pirfenex 200mg (Pirfenidone 200mg) should be stored at the temperature below 25℃. The container should be kept in cool and dry place.
Missed dose of Pirfenex 200mg (Pirfenidone 200mg)
If a dose is missed, then have the dose as soon as possible before the next dose timing or skip the missed dose and continue daily schedule. Do have extra dose for any cost Please consult with the doctor for further details.
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