Posid 50mg (Etoposide)

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Brand namePosidInternational trade nameVePesidActive substanceEtoposideStrength50mgCategoryAnti Cancer

Description of Posid 50mg (Etoposide 50mg)

Posid 50mg (Etoposide 50mg) is a cytotoxic chemotherapy regimen. This medicine belongs to type of classification as a "plant alkaloid" and "topoisomerase II inhibitor.
The accurate way which Posid 50mg (Etoposide 50mg) works against cancer is not known. However, it seems to inhibit the development of the cancer cells, which are ultimately destroyed.
Posid 50mg (Etoposide 50mg) is a prescription medicine provided under guidance of medical practioners.

Medical use /Indication of Posid 50mg (Etoposide 50mg)

Posid 50mg (Etoposide 50mg) Capsule indicated in concomitant with other chemotherapeutic agents for the treatment;
• Hodgkin's and non-Hodgkin's lymphoma, Testicular, bladder, Wilm's tumor, lung, stomach, and uterine, cancers, mycosis fungoides, Kaposi's sarcoma, rhabdomyosarcoma, Ewing's sarcoma, neuroblastoma, brain tumors.
• And for high-dose treatment in bone marrow transplant setting

Mechanism of Action Posid 50mg (Etoposide 50mg)

Etoposide prohibits DNA combination by forming a complex with topoisomerase II and DNA. This complex lead to breaks in double stranded DNA and inhibits repair by topoisomerase II binding. Collect breaks in DNA inhibits entry into the mitotic phase of cell division and causes cell death. Etoposide acts mainly in the G2 and S phases of the cell cycle.

ADME of Posid 50mg (Etoposide 50mg)

  • Peak plasma time is 1 hr
  • Bioavailability are 25-75%
  • Peak plasma concentration is 4.7 mcg/mL
  • Clearance: 13.4 mL/min
  • Protein bound: 94-98%
  • Vd: 7-17 L/m²
  • Metabolized in Liver
  • Half-Life: 4-11 hr
  • Excretion: Urine (35%)

Side effects of Posid 50mg (Etoposide 50mg)

Common side effects of Posid 50mg (Etoposide 50mg) :

  • Allergic reaction: Chills, Fever, tachycardia, bronchospasm, Dyspnea
  • Alopecia
  • Malaise
  • Dysphagia
  • Low WBC count
  • Low platelet count
  • Loss of hair
  • Menopause
  • Fertility loss
  • Vomiting and nausea
  • Hypotension.

Less common side effects of Posid 50mg (Etoposide 50mg) :

  • Cortical blindness
  • Interstitial pneumonitis
  • Mouth ulcers
  • Diarrhae
  • Stomatitis
  • Decreased appetite
  • Radiation Recall.

Other side effects :

  • Metallic taste during medicine infusion
  • Inflammation at Capsules site

Precautions of Posid 50mg (Etoposide 50mg)

The medicine causes Low blood pressure with rapid infusion of the medication

If platelet <50,000/mm³ or ANC <500/mm³, withhold further treatment

The Etosid will results in Severe bone marrow depression

Etosid may increase your risk of getting a second cancer, such as leukemia

If patient have hepatic impairment use with caution

During administration Capsule site reactions may occur; check closely

Drug interaction of Posid 50mg (Etoposide 50mg)

  • Concomitant use of Posid 50mg (Etoposide 50mg)with Apalutamide will reduces the level or effect of Etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
  • When concomitant use of Posid 50mg (Etoposide 50mg)with idelalisib will increase the level or effect of Etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
  • Posid 50mg (Etoposide 50mg) will decrease the effects of influenza virus vaccine trivalent adjuvanted by pharmacodynamic antagonism
  • When interaction of Posid 50mg (Etoposide 50mg) with Nefazodone will increase the level or effect of Etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Contraindication of Posid 50mg (Etoposide 50mg)

The medicine Posid 50mg (Etoposide 50mg) contraindicated to hypersensitivity to Etoposide or any component of the formulation

Pregnancy of Posid 50mg (Etoposide 50mg)

Posid 50mg (Etoposide 50mg) has pregnancy category D

Avoid the medicine during pregnancy because of potential harm to the fetus

Lactation of Posid 50mg (Etoposide 50mg)

Advice breastfeed mother about possible risk to the fetus. Avoid breastfeeding during treatment

Dosage of Posid 50mg (Etoposide 50mg)

The usual dose for testicular cancer is 50-100mg/m2/day Iv on days 1-5 or 100mg mg/ m2/day IV on days 1,3,5

Repeat the course for q3-4week

The usual dose for small-cell lung cancer is 35 mg/ m2/day IV for 4 days or 50 mg/ m2/day IV for 5 days

Repeat the course for q3-4week

Monitor the patients CBC, Hgb, LFTs, Renal function

Storage of Posid 50mg (Etoposide 50mg)

Posid 50mg (Etoposide 50mg) should be stored under refrigeration at 20 ℃- 80℃

Dispense the medicine in tight container

Missed dose of Posid 50mg (Etoposide 50mg)

If the patient fails to take a dose of medicine or missed to take a dose, then should not take an extra dose, but to take the next dose at the regular time, leave the missed dose.

Brand name:
International trade name:
Active substance:
Anti Cancer
Cadila Pharmaceuticals
8 Capsules
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