Ricovir 300mg (Tenofovir Disoproxil Fumarate)

Tenofovir Disoproxil Fumarate
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Ricovir 300mg (Tenofovir Disoproxil Fumarate)

ManufacturerMylanBrand nameRicovirInternational trade nameVireadActive substanceTenofovir Disoproxil FumarateStrength300mgCategoryHEPATITIS B, HIV

Description of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg)

Tenofovir Disoproxil Fumarate Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) is FDA approved product, containing anti-viral activity against both HIV infection and HBV infection. Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) is a most dominant, first line therapy used by the patients only under the knowledge of medical practitioner who are well trained

Medical use /Indication of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg)

Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) tablets are primarily indicated in the conditions like :

HIV infection :

In HIV infection, Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) tablet is not used alone it may combined with other anti-retroviral medicines (like NNRTI or PI)

Chronic hepatitis B infection :

Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) is used in the treatment of severe hepatitis B viral infection mainly in adults

Body works for Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg)

Tenofovir disoproxil fumarate is a promedicine which is converted into an active form tenofovir in-vivo. The oral bioavailability of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) tablet is reaches relatively at 25% The peak serum concentration occurs within 1.0 hours ± 0.4 hours Binding of tenofovir with human plasma protein or serum proteins is occurred in-vitro as less than 0.7% & 7.2% respectively The volume of distribution occurs at steady state 1.3±0.6L/kg The metabolism of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) tablet occurs hepatically to form active tenofovir diphosphate which is pharmacologically active form with the help of cellular enzymes The terminal half life period of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) occurs nearly 17 hours The effect of food with Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) tablet on oral administration, with high fat meals increase the oral bioavailability at 40 to 50%

Side effects of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg)

  • Some undesirable effects occur during or after the therapy; Immune restructuring syndrome
  • Serious acute aggravation of hepatitis B infection
  • New outbreak of renal impairment
  • Depletion of bone mineral density
  • Lactic acidosis or serious hepatomegaly with steatosis.
  • Some common effects; Headache, Pain, Fever, Abdominal pain, Back pain, Asthenia, Diarrhea, Nausea, Dyspepsia, Vomiting, Arthralgia,
  • Myalgia, Depression, Insomnia, Dizziness, Anxiety, Lipodystrophy, Pneumonia, Rashes.

Drug interaction of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg)

Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) containing active component tenofovir disoproxil fumarate interacts with some medicines and produce adverse effects Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) tablet concomitant with Didanosine, while receiving these medicine at same time may produce some adverse effects related to Didanosine to avoid this problem stop the Didanosine tablet immediately While concurrent use of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) with HIV 1 protease inhibitor, increases the concentration of tenofovir Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) is a substrate of P-gp & BCRP transporters, whereas co administration of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) with P-gp inhibitors may increase the absorption Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) with Lopinavir/ritonavir, ritonavir boosted atazanavir or ritonavir boosted darunavir should increase the tenofovir associated adverse effects Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) co administered with hepatitis C anti-viral agents may have a chance to increase the tenofovir exposure Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) is excreted through renal, if Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) tablet concomitant with medicines which decrease the renal function may elevates the serum concentration of tenofovir disoproxil fumarate. Some examples like acyclovir, cidofovir, valganciclovir, valaciclovir, amino glycosides

Precaution of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg)

In lactic acidosis or serious hepatomegaly with steatosis: To avoid this problem, patient must discontinue the therapy or postpone Severity of hepatitis B infection after conclusion of therapy: Patients who are discontinue the therapy, should be monitored frequently Continue the therapy if required Aggravation of renal impairment Mostly tenofovir is eliminated renally; creatinine clearance must be monitored periodically before starting the treatment Serum phosphorus, renal protein, creatine clearance, urine glucose values should be monitored before begin the therapy Avoid concurrent use of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg)  with medicines which reduce the renal function or nephrotoxic agents Care should be taken while using in patients who are co infected with HIV-1 & HBV Major adverse effect is bone mineral density depletion, may leads to osteoporosis to avoid this condition calcium and vitamin D supplements should be provided Mineralization defects occurs

Contraindication of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg)

Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) tablet have no contraindication But some hypersensitivity reaction may occur if patients are contraindicated to the component of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) tablet 

Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg)   in PREGNANCY

Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg)  tablets should be safe to use But in some patients placental transformation occurs, in that condition Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg)  should not be recommended

Generally HIV infected women not breast feed the child, to avoid spreading of infection to babies through human milk

Dosage of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg)

Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg)  is used as a single dose regimen Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) tablets should be taken with or without food Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) tablets recommended dosage in the conditions like HIV-1 & HBV infections; In adults & pediatric around the age of 12 years or weight of 35kg or more in hepatitis B infection and 2 years of age in HIV condition; One Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) tablet 300mg should be administered orally as a single dose with or without food The dosage of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) should be calculated on the basis of creatinine clearance value and body weight of the patients In renal impairment patients, hemodialysis occurs weekly three sessions around 4 hours. Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) tablets should be taken only after conclusion of dialysis

Depending on body weight of pediatrics

17 to <22kg: 150mg , 22 to <28kg: 200mg , 28 to <35: 250mg , ≥35kg: 300mg.
In adults: Depending on creatine clearance; ≥50ml/min: 300mg of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg)  should be given every 24 hours 30 to 49ml/min: 300mg should be recommended for every 48 hours 10 to 29 ml/min: 300mg recommended dosage for every 72 to 96 hours In hemodialysis patients: Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) tablets should be taken every 7 days or after 12 hours of dialysis

Storage of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg)

Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) tablet container should be stored at room temperature at below 30℃ Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) should be kept in dry and cool place Container should be keep away from moisture, heat and light 

Missed dose of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg)

Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) tablet should be used only under the guidance of medical practitioner, if patient fail to take the dose of Ricovir 300mg (Tenofovir Disoproxil Fumarate 300mg) tablet, must consult the physician and take the dose as soon as possible Otherwise the missed dose should be discontinued and follow the regular dosing schedule Do not take over dose

Brand name:
Ricovir
International trade name:
Viread
Active substance:
Tenofovir Disoproxil Fumarate
Strength:
300mg
Category:
HEPATITIS B, HIV
Manufacturer:
Mylan
Packaging:
30 Tablet
Product form:
Tablet

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