Thalitero 50mg (Thalidomide)

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Hetero Drugs Ltd

Thalitero 50mg (Thalidomide)

ManufacturerHetero Drugs LtdBrand nameThaliteroInternational trade nameThalomidActive substanceThalidomideStrength50mgCategoryAnti Cancer

Description of Thalitero 50mg (Thalidomide 50mg)

Thalidomide is a generic of brand name of Thalitero 50mg (Thalidomide 50mg).
Thalitero 50mg (Thalidomide 50mg) appeared as a hopeful alternative to barbiturates which were then needed as sedatives, because it didn’t seem to be toxic nor have any side effects. The overdose would only cause deep sleep, as hostile to barbiturates which could cause death if taken in more quantity.It has been renewing and indicated for several immunological and inflammatory disorders. 

Thalitero 50mg (Thalidomide 50mg) displays immunosuppressive and anti-angiogenic activity. It prevents release of tumor necrosis factor-alpha from monocytes and modulates another cytokine action

Medical use /Indication of Thalitero 50mg (Thalidomide 50mg)

Thalitero 50mg (Thalidomide 50mg) is indicated for treatment of skin lesions associated with leprosy. 

Thalitero 50mg (Thalidomide 50mg) is indicated in various cancer conditions such as: multiple myeloma, renal cell carcinoma, glioblastoma multiforme and Waldenström macroglobulinemia.

As well as treatment of graft vs. host disease (GVHD) after bone marrow transplant.

Mechanism of Action Thalitero 50mg (Thalidomide 50mg)

Extra, thalidomide is known to have different effects on the immune system (immunomodulatory agent), which may provide to its healing effect. Thalidomide may also change the production and activity of cytokines (growth factors) contains in the growth and durability of certain cancer cells. There may be an effect on the genes which direct the cell's development and activity specifically those along with cytokines (growth factors), apoptosis (cell death), and metabolism.

Absorption of Thalitero 50mg (Thalidomide 50mg)

Time to peak plasma concentration is 2.9 to 5.7 hours

Distribution of Thalitero 50mg (Thalidomide 50mg)

plasma protein binding is 55% and 66% for the (+) R and (-) S enantiomers, respectively

Metabolism of Thalitero 50mg (Thalidomide 50mg)

Metabolized hepatically by enzymes of the cytochrome P450 enzyme system

Excretion of Thalitero 50mg (Thalidomide 50mg)

excreted in the urine as unchanged medicine is less than 0.7% of the dose.

Half-life of thalidomide is 5 to 7 hours.

Side effects of Thalitero 50mg (Thalidomide 50mg)

  • Neutropenia
  • Thrombocytopenia
  • Increased HIV viral load
  • Bradycardia
  • Seizures
  • Tumor Lysis
  • Hypersensitivity
  • Teratogenicity
  • Venous and arterial thromboembolism
  • Increased Mortality
  • Drowsiness and somnolence
  • Peripheral neuropathy
  • Dizziness and orthostatic hypotension

Precautions of Thalitero 50mg (Thalidomide 50mg)

For both men and women use contraceptives, and do not conceive a child (get pregnant) while taking Thalitero 50mg (Thalidomide 50mg). serious, life-threatening birth defects may have reported with even one 50 mg dose. Methods of contraception has two types, such as latex condoms and spermicides, are required.

For women of childbearing potential should use contraception 4 weeks before you can start Thalitero 50mg (Thalidomide 50mg). The manufacturer needed you to take a pregnancy test every month before you initiate a new prescription of thalidomide. This is to confirm that you or your significant other is not pregnant. Consult with your doctor when you may safely become pregnant or conceive a child after treatment.

Prior initiating Thalitero 50mg (Thalidomide 50mg) treatment, make sure to inform doctor about any other medications you are taking (containing prescription, over-the-counter, vitamins, herbal remedies, etc.). Avoid taking aspirin, or products including aspirin untilthe doctor especially permits this.
Avoid taking regimens that may cause drowsiness without first consulting your health care provider. Also avoid alcohol.
Do not breast feed while taking this medication.

Drug interaction of Thalitero 50mg (Thalidomide 50mg)

Combination of Thalitero 50mg (Thalidomide 50mg)  with opioids, antihistamines, antipsychotics, anti-anxiety agents, other CNS depressants may lead to additive sedative effect.

Concomitant use of Thalitero 50mg (Thalidomide 50mg)  with cardiovascular medication will cause an additive bradycardic effect and should be used with caution. Interaction with bortezomib, amiodarone, cisplatin, docetaxel, paclitaxel, vincristine etc will cause peripheral neuropathy and should be used with caution.

Unknown condition when concomitant use of hormonal contraceptives further increases the risk of thromboembolism with Thalitero 50mg (Thalidomide 50mg)

Contraindication of Thalitero 50mg (Thalidomide 50mg)

Pregnancy - the medicine cause risk to fetal

Pregnancy of Thalitero 50mg (Thalidomide 50mg)

Pregnancy category X: Thalitero 50mg (Thalidomide 50mg) may cause risk to fetal when administer to a pregnant woman. This medicine should not administer to a pregnant woman or a woman who aims to become pregnant.

Lactation of Thalitero 50mg (Thalidomide 50mg)

There has no data available for the presence of Thalitero 50mg (Thalidomide 50mg) in human milk and effects of medicine on breastfed infants.

Avoid breastfeeding during treatment with Thalitero 50mg (Thalidomide 50mg) 100mg

Dosage of Thalitero 50mg (Thalidomide 50mg)

The dosage recommendation of following condition as follows :

Multiple Myeloma :

The prescribed dose is 200mg PO qHS in 28-day cycles

Take 40 mg of dexamethasone on days 1-4,9-12,17-20 of 28 days.

Erythema Nodosum leprosum :

The initial prescribed dose is 100-300 mg PO qHS.

If more severe reaction then may initiate at 400mg. continue until active symptoms subsided, at least 2 weeks then titrate down by 50 mg increment q 2-4 weeks.

Storage of Thalitero 50mg (Thalidomide 50mg)

Store at 20℃ - 25℃.

Protect the medicine from light

Missed dose of Thalitero 50mg (Thalidomide 50mg)

Take the dose immediately before next dose duration. Next dose time reaches then left off the missed dose and continue regular schedule. Avoid taking double dose at same time. Please consult the doctor for further information.

Brand name:
International trade name:
Active substance:
Anti Cancer
Hetero Healthcare Ltd
10 Capsules
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