Zidine 300mg (Zidovudine)
Description of Zidine 300mg (Zidovudine 300mg)
Zidine 300mg (Zidovudine 300mg) belongs to nucleoside reverse transcriptase inhibitor. Reverse transcriptase enzyme is effective for viral development. Zidine 300mg (Zidovudine 300mg) tablets are co administration with tablets which containing an active composition known as zidovudine as an anti-retroviral medications and is combine with other anti-retroviral drugs for better activity. Patients administrating Zidine 300mg (Zidovudine 300mg) tablets treatment should have better able to attach to multiple drug treatment drugs, thereby developing the compliance.
INDICATIONS of Zidine 300mg (Zidovudine 300mg)
Zidovudine is an antiviral medicine used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Zidovudine is also given during pregnancy to prevent an HIV-infected woman from passing the virus to her baby. Zidovudine is not a cure for HIV or AIDS.
MECHANISM OF ACTION of Zidine 300mg (Zidovudine 300mg)
The mechanism of action of zidovudine is also similar to lamivudine, like prohibition of viral reverse transcriptase by zidovudine triphosphate which is an active molecule of zidovudine. At last viral DNA chain ends occurs.
Absorption of Zidine 300mg (Zidovudine 300mg)
Quickly absorps and peak plasma level of Zidine 300mg (Zidovudine 300mg) is 0.5 to 1.5hours;
Distribution of Zidine 300mg (Zidovudine 300mg)
Highly distributed in body. The fundamental of Zidine 300mg (Zidovudine 300mg) tablets are binding to human plasma protein with the range of <38% for zidovudine. The binding serum ratio of Zidine 300mg (Zidovudine 300mg) is less.
Metabolism of Zidine 300mg (Zidovudine 300mg)
Zidovudine is go through metabolism by glucoronide conjugation.
Elimination of Zidine 300mg (Zidovudine 300mg)
Route of elimination of zidovudine is urine 29%; excreted as zidovudine metabolite 45%. The zidovudine half life period of is 0.5 to 3 hours.
SIDE EFFECTS of Zidine 300mg (Zidovudine 300mg)
Loss of appetite Dyspepsia Abdominal cramps Neuropathy Insomnia Myalgia Arthralgia Dizziness Depression Nasal signs Headache Malaise Fatigue Anorexia Cough Rashes Musculoskeletal pain
The most serious adverse effects are :
Hematological toxicity Symptomatic myopathy Lactic acidosis or hepatomegaly with steatosis Aggravation of hepatitis B Hepatic decompensated cirrhosis in patient with HCV/HIV co infection. Aggravation of anemia due to patients who are co infected with HIV-1/HCV getting ribavirin & zidovudine. Pancreatitis Immune reconstitution syndrome Lipoatrophy
PRECAUTION of Zidine 300mg (Zidovudine 300mg)
The possible adverse occurred during or after completion of therapy with Zidine 300mg (Zidovudine 300mg).
In case of neutropenia or thrombocytopenia, Zidine 300mg (Zidovudine 300mg) treatment should be postponed. Periodic blood cells count should be taken.
Lactic acidosis or hepatomegaly with steatosis :
This condition may leads to produce fatal cases, majorly in women. The most common adverse effect is obesity In severe condition treatment should be discontinued.
In HIV-1 infected patients who are receiving Duovir having a chance of getting myopathy. The prolonged use of zidovudine is responsible for onset of myopathy in patients.
Hepatitis B co infection :
To overcome the post treatment aggravation of hepatitis infection, patient should be monitored with hepatic function frequently after completion of treatment. The concurrent use of lamivudine may leads to cause this type of infection.
DRUG INTERACTION of Zidine 300mg (Zidovudine 300mg)
Drugs which are opposing the activity of zidovudine; The interaction of zidovudine with some drugs produces antagonist effects, like Stavudine Doxorubicin Nucleoside analogues like ribavirin Concurrent use with ribavirin, Ganciclovir, interferon alfa or other drugs may elevate the hematological toxicity effect of zidovudine. Avoid this concomitant treatment. Zidine 300mg (Zidovudine 300mg) should not be interact with Zalcitabine which may changes or prohibits the intracellular phosphorylation of one another.
CONTRAINDICATION of Zidine 300mg (Zidovudine 300mg)
The patient are contraindicated to the component present in Zidine 300mg (Zidovudine 300mg) tablets then Anaphylactic reaction may occur
OVERDOSAGE of Zidine 300mg (Zidovudine 300mg)
The over dosage of Zidine 300mg (Zidovudine 300mg) should be treated by undergoing hemodialysis. Hemodialysis helps to remove the content of zidovudine from the body. Provide supportive measures.
PREGNANCY & LACTATION of Zidine 300mg (Zidovudine 300mg)
The pregnancy category of Zidine 300mg (Zidovudine 300mg) is C
Animal reproduction studies have shown adverse effect on fetus while in human there are no sufficient and well tolerated studies, but possible use may warrant the in drug in pregnant women produce possible risk.
Generally HIV infected patients should not feed the baby. Zidine 300mg (Zidovudine 300mg) metabolites are eliminated via human breast milk.
DOSAGE of Zidine 300mg (Zidovudine 300mg)
In adult :
The recommended dose is 300mg Zidovudine capsules for twice daily in combination with other antiretroviral.
Pediatric patients (age of 4 weeks to < 18 years) :
The dose is usually calculated based on body weight(kg) and not to be exceed the usual adult dose The patient body weight 4 to <9 = 24mg/kg/day given as 12mg/kg twice daily; 8mg/kg three times daily >9 to >30 = 18mg/kg/day given as 9mg/kg for twice daily ; 6mg/kg three times daily ≥ 30 = 600mg/day given as 300mg for twice daily ; 200mg for three times daily
Prevention of maternal-fetal HIV-1 transmission :
Maternal dosing: Before start of labor administrate 100mg orally 5 times /day. During labor and delivery, administered 2mg/kg IV over 1 hour followed by a continuous IV infusion of 1mg/kg/hr until clamping of umbicalcord Neonatal dosing After birth Dosing within 12 hours and continue through 6 weeks of age Oral route = 8mg/kg/day total daily dose but given as 2mg/kg for every 6 hours Intrevenous route = 6mg/kg/day total daily dose but given as 1.5mg/kg infused over 30min, every 6hrs Zidine 300mg (Zidovudine 300mg) tablet should be administered with or without food.
STORAGE of Zidine 300mg (Zidovudine 300mg)
Stored at 20 to 25℃.
Store the drug away from moisture, heat & light.
MISSED DOSE of Zidine 300mg (Zidovudine 300mg)
If a dose is missed by the patient then have the dose as soon as possible or skip the medicine and follow regular schedule. Please consult with the doctor
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