applepharmaceutical@gmail.com
drug

PRODUCT DETAILS

Generic : Bendamustine
Trade name : Purplz
Strength : 100mg
Manufactured by : Dr. Reddy’s Laboratories
Packing : 1 injection in a vial

for MORE INFORMATION !!!

Purplz belongs to bifunctional mechlorethamine derivative accomplished of forming electrophilic alkyl groups which covalently bond to other molecules. Over this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death.
It is active against both active and quiescent cells, even though the exact mechanism of action is unknown. Purplz is a prescription drug which is used under the guidance of medical supervision

INDICATION

Purplz 100mg is used for the treatment for Chronic lymphocytic Leukaemia in patients.
Purplz 100mg is used for the treatment for Indolent B-cell non-Hodgkin’s lymphoma in patients

DOSAGE

For chronic lymphocytic Leukaemia:
The Purplz usual dose is 100mg/m2 IV infusion on days 1 and 2 of 28-day cycle, repeated for up to 6 cycles
Non-Hodgkin Lymphoma:
The Purplz usual dose is 120mg/m2 IV infusion on days 1 and 2 of 21-day cycle repeated for up to 8 cycles

MECHANISM OF ACTION

Bendamustine belongs to alkylating agent, a chemical which can be internalized by cell and cause abnormal bonds between strands of DNA. This is an irreversible process which inhibits the cell from replicating and causes the affected cell to die.
Bendamustine works in both cancerous and healthy cells.

PHARMACOKINETICS

Time to peak plasma: At end of infusion
Protein bound: 94-96%
Volume of distribution: 25L
Metabolized by CYP1A2
Excretion: Feces 90%; Urine 1-10%
Half-life: 40min

PRECAUTION

Serious infusion and anaphylactic reactions resulted; check clinically and stops treatment; premeditate in consecutive cycles for milder reactions
While on treatment will causes tumor lysis syndrome occurs; acute renal failure and death may reported; anticipate and use supportive measures
Probably of anaphylactic/infusion reactions: serious in rare cases
Myelosuppression may report; decrease dose; restart treatment based on ANC and platelet count recovery; difficult situation of myelosuppression may lead to death
Check further fever and other signs of infection and treat promptly.

DRUG INTERACTION

Purplz co administration with CYP1A2 inhibitors will have probably to increase plasma concentration of bendamustine and decrease plasma concentration of active metabolites.
Purplz co administration with CYP1A2 inducers will have probably to decrease plasma concentration of bendamustine and increase plasma concentration of active metabolites.

CONTRAINDICATION

Known hypersensitivity to bendamustine and its metabolites

STORAGE

Store in refrigerator at 2℃ to 8℃
keep in original containers until time of use.

MISSED DOSE

If dose is missed, then have immediately before the reaching of next dose time or swap the missed dose and continue regular schedule. Consult the doctors for more information.

SIDE EFFECTS

Common side effects :
Nausea
Vomiting
Fatigue
Diarrhae
Rash
Decreased blood counts
Infusion reaction
Fever.
Some rare side effects :
Infertility.

We'd Like to Hear From You!

PRESCRIPTION POLICY

1. myapplepharma.com, a fully licensed and regulated pharmacy, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.
2. myapplepharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.
3. If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.
4. The drug information provided in the myapplepharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.
5. myapplepharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from myapplepharma.com.
6. At myapplepharma.com, a Caregiver can order prescription medicines on your behalf.


This information should not be used to decide whether to accept this product or any other medicine. Only a health care provider is knowledge and training to decide that a medicine suitable for a specific patient. This information does not support any drug as safe, are effective or approved for the treatment of any patient or health condition. It's simple a brief overview of general information about this product. It does not include all information on possible applications, indications, warnings, precautions, interactions, adverse effects or risks that may be relevant to this product. This information is not specific medical advice and does not replace information obtained from your health care provider. You should check with your health care provider for complete information about the risks and benefits of using this product.