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Ricovir-300mg

PRODUCT DETAILS

Brand Name : Ricovir
Active components : Tenofovir Disoproxil Fumarate
Strength of the components : 300mg
Manufactured by : Mylan Pharmaceuticals
Category : Anti-hepaciviral & Anti-retro viral agent
Package : 30 tablets in a container

for MORE INFORMATION !!!

Tenofovir Disoproxil Fumarate Ricovir is a Mylan which is FDA approved product, containing anti-viral activity against both HIV infection and HBV infection. Ricovir is a most dominant, first line therapy used by the patients only under the knowledge of medical practitioner who are well trained

TABLETS USED FOR

Ricovir tablets are primarily indicated in the conditions like :
HIV infection :
In HIV infection, Ricovir tablet is not used alone it may combined with other anti-retroviral medicines (like NNRTI or PI)
Chronic hepatitis B infection :
Ricovir is used in the treatment of severe hepatitis B viral infection mainly in adults

BODY WORKS FOR RICOVIR

Tenofovir disoproxil fumarate is a prodrug which is converted into an active form tenofovir in-vivo. The oral bioavailability of Ricovir tablet is reaches relatively at 25% The peak serum concentration occurs within 1.0 hours ± 0.4 hours Binding of tenofovir with human plasma protein or serum proteins is occurred in-vitro as less than 0.7% & 7.2% respectively The volume of distribution occurs at steady state 1.3±0.6L/kg The metabolism of Ricovir tablet occurs hepatically to form active tenofovir diphosphate which is pharmacologically active form with the help of cellular enzymes The terminal half life period of Ricovir occurs nearly 17 hours The effect of food with Ricovir tablet on oral administration, with high fat meals increase the oral bioavailability at 40 to 50%

DOSAGE

Tenofovir disoproxil fumarate is a prodrug which is converted into an active form tenofovir in-vivo. The oral bioavailability of Ricovir tablet is reaches relatively at 25% The peak serum concentration occurs within 1.0 hours ± 0.4 hours Binding of tenofovir with human plasma protein or serum proteins is occurred in-vitro as less than 0.7% & 7.2% respectively The volume of distribution occurs at steady state 1.3±0.6L/kg The metabolism of Ricovir tablet occurs hepatically to form active tenofovir diphosphate which is pharmacologically active form with the help of cellular enzymes The terminal half life period of Ricovir occurs nearly 17 hours The effect of food with Ricovir tablet on oral administration, with high fat meals increase the oral bioavailability at 40 to 50%

Depending on body weight of pediatrics

17 to <22kg: 150mg, 22 to <28kg: 200mg, 28 to <35: 250mg, ≥35kg: 300mg.
In adults: Depending on creatine clearance; ≥50ml/min: 300mg of Ricovir should be given every 24 hours 30 to 49ml/min: 300mg should be recommended for every 48 hours 10 to 29 ml/min: 300mg recommended dosage for every 72 to 96 hours In hemodialysis patients: Ricovir tablets should be taken every 7 days or after 12 hours of dialysis

WORK AS

Ricovir comprises of tenofovir disoproxil fumarate (TDF), acyclic nucleoside phosphonate diester analogue of adenosine monophosphate TDF desires initial diester hydrolysis for alteration of TDF into tenofovir Tenofovir is a parent compound, which is further phosphorylated into tenofovir diphosphate with the support of cellular enzymes. This active metabolite tenofovir diphosphate acts as chain dominator Ricovir exhibits its activity by insertion of tenofovir diphosphate into viral DNA and prohibits the effect of HIV-1 & HBV reverse transcriptase against the natural substrate deoxyadenosine 5’-triphosphate after insertion

PRECAUTION

In lactic acidosis or serious hepatomegaly with steatosis: To avoid this problem, patient must discontinue the therapy or postpone Severity of hepatitis B infection after conclusion of therapy: Patients who are discontinue the therapy, should be monitored frequently Continue the therapy if required Aggravation of renal impairment Mostly tenofovir is eliminated renally; creatinine clearance must be monitored periodically before starting the treatment Serum phosphorus, renal protein, creatine clearance, urine glucose values should be monitored before begin the therapy Avoid concurrent use of Ricovir with drugs which reduce the renal function or nephrotoxic agents Care should be taken while using in patients who are co infected with HIV-1 & HBV Major adverse effect is bone mineral density depletion, may leads to osteoporosis to avoid this condition calcium and vitamin D supplements should be provided Mineralization defects occurs

DRUG INTERACTION

Ricovir containing active component tenofovir disoproxil fumarate interacts with some drugs and produce adverse effects Ricovir tablet concomitant with Didanosine, while receiving these drug at same time may produce some adverse effects related to Didanosine to avoid this problem stop the Didanosine tablet immediately While concurrent use of Ricovir with HIV 1 protease inhibitor, increases the concentration of tenofovir Ricovir is a substrate of P-gp & BCRP transporters, whereas co administration of Ricovir with P-gp inhibitors may increase the absorption Ricovir with Lopinavir/ritonavir, ritonavir boosted atazanavir or ritonavir boosted darunavir should increase the tenofovir associated adverse effects Ricovir co administered with hepatitis C anti-viral agents may have a chance to increase the tenofovir exposure Ricovir is excreted through renal, if Ricovir tablet concomitant with drugs which decrease the renal function may elevates the serum concentration of tenofovir disoproxil fumarate. Some examples like acyclovir, cidofovir, valganciclovir, valaciclovir, amino glycosides

WARNING

Ricovir tablets used patients have chance to get; Lactic acidosis & severe hepatomegaly with steatosis After therapy, there is a chance of getting severe worsening of HBV viral infection

MISSED DOSE

Ricovir tablet should be used only under the guidance of medical practitioner, if patient fail to take the dose of Ricovir tablet, must consult the physician and take the dose as soon as possible Otherwise the missed dose should be discontinued and follow the regular dosing schedule Do not take over dose

CONTRAINDICATION

Ricovir tablet have no contraindication But some hypersensitivity reaction may occur if patients are contraindicated to the component of Ricovir tablet

SIDE EFFECTS

Some undesirable effects occur during or after the therapy; Immune restructuring syndrome
Serious acute aggravation of hepatitis B infection
New outbreak of renal impairment
Depletion of bone mineral density
Lactic acidosis or serious hepatomegaly with steatosis.
Some common effects :
Headache, Pain, Fever, Abdominal pain, Back pain, Asthenia, Diarrhea, Nausea, Dyspepsia, Vomiting, Arthralgia, Myalgia, Depression, Insomnia, Dizziness, Anxiety, Lipodystrophy, Pneumonia, Rashes.

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