Trade name : Stavir
Active ingredient : Stavudine
Strength availability : 30mg
Manufactured by : Cipla
Package : 60 tablets in a container
Dosage Form : Tablets


Stavir is type of synthetic thymidine nucleoside analogue, and exist as antiretroviral agents. Primarily the drug Stavir is effective against the human immunodeficiency virus type 1 (HIV-1) and AIDS and it’s not applicable for first line treatment Stavir belongs to an dideoxynucleoside analog which prohibits the reverse transcriptase and has in vitro activity against HIV. Stavir is not a cure for HIV or AIDS. Stavir is a prescription drug which is used under guidance of physician


Stavir capsules in concomitant use with other antiretroviral drugs which are used to treat the human immunodeficiency virus (HIV)-1 infection. Stavir is may also required for inhibition after a needlestick injury or other potential exposure.


The usual dose of the adult to treat of HIV infection The dosage of Stavir is primarily depends on body weight as follows: Administer 30mg every 12 hours for the patients weighing < 60kg. Administered 40mg every 12 hours for the patients weighing at least 60kg .
Usual dose for pediatrics : For newborns from birth to 13 days old given 0.5mg/kg given 12 hours For pediatric patients at least 14 days old administered 1mg/kg given every 12 hours Use same adult dose for pediatric patients weighing at least 30kg


Stavudine, is belongs to nucleoside analogue of thymidine, and by cellular kinases to the active metabolite is phosphorylated to Stavudine triphosphate. Stavudine triphosphate prohibits the activity of HIV-1 reverse transcriptase (RT) by battle with the natural substrate thymidine triphosphate (Ki=0.0083 to 0.032 μM) and by resulting DNA chain termination following its fusion into viral DNA. Stavudine triphosphate prohibits cellular DNA polymerases β and γ and markedly decreases the coalescence of mitochondrial DNA.


Absorption: Fastly absorped with high serum concentrations occurring within 1 hour after dosing.
Distribution: Human plasma protein bounding is negligible
Metabolism :
The active substrate for HIV- reverse transcriptase is phosphorylated intracellularly to Stavudine triphosphate.
Elimination :
The total radioactivity was eliminated in urine 95% and feces 3% respectively. Stavudine administrating to healthy subjects following 80mg dose.


Neurologic symptoms : Motor weakness has been resulted rarely in patients getting combination with antiretroviral treatment involving Stavudine and patients should be monitored for the growth of peripheral neuropathy.
Hepatic toxicity : HIV patients with significant underlying liver disease, the safety and efficacy of stavudine have not been established. If combination with antiretroviral therapy, some serious problem arises and potentially fatal hepatic adverse events and should be checked according to standard practice.
Lactic acidosis : Severe hepatomegaly with steatosis and lactic acidosis with the use in combination or nucleoside analogues involves stavudine and other antiretrovirals.
Fat redistribution : Redistribution/aggregation of body fat involving central obesity, dorsocervical fat augmentation (buffalo hump), peripheral wasting, facial wasting, breast enlargement, and “cushingoid appearance” have been observed in patients getting antiretroviral therapy.


Interaction of Stavir with zidovudine will competitively prohibits the intracellular phosphorylation of Stavudine . Concomitant use of Stavir with doxorubicin should be taken with caution, it will cause to the phosphorylation of Stavudine is prohibit at relevant concentrations by doxorubicin. While co administration of Stavir with ribavirin will decrease phosphorylation of Lamivudine, Stavudine and zidovudine.


In patients Stavir capsules is contraindicated with hypersensitivity to Stavudine or to any of the components.


If a dose is missed by patient then have the dose you remember before next dose or leave the missed dose then follow the regular schedule. Please consult with the doctor.


The recommended daily dosage exposes no acute anitoxin. The chronic dosage complexity includes peripheral neuropathy and hepatic toxicity. Stavudine can be removed by hemodialysis


While using with drug most people affect with some side effect. Some of them are listed below :
Decreased in platelets count , Elevation of blood glucose level, Increased bilirubin, Increased serum AST, ALT, Increased alkaline phosphatase, Insomnia, Abnormal dreams, Fatigue, Neutropenia, Anemia, Headache, Nausea, Asthenia, Abdominal pain, Gastritis, Hepatitis, Hypersensitivity, Stevens Johnson syndrome, Herpes zoster, Dizziness, Renal failure, Suicidal ideation, Rash.

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