applepharmaceutical@gmail.com
drugs

PRODUCT DETAILS

Brand Name : Sutent
Composition : Sunitinib
Strength availability : 12.5mg
Manufactured by : Pfizer’s Ltd
Pack : 28 capsules in a bottle
for MORE INFORMATION !!!

Sutent 12.5mg is an antineoplastic drug which prevents the growth and spread of cancer cells in the body.
Sutent 12.5mg belongs to targeted therapy and is a receptor protein-tyrosine kinase inhibitor. It prohibits the actions of vascular endothelial growth factor (VEGF) and is an angiogenesis inhibitor.
Sutent 12.5mg is a prescription drugs which is used under the guidance of medical practioners

INDICATION

Sutent 12.5mg is used for the treatment in patients having Gastrointestinal stromal tumor
Sutent 12.5mg is used for the treatment in patients having Advanced pancreatic neuroendocrine tumor
Sutent 12.5mg is used for the treatment in patients having Advanced renal cell cancer

DOSAGE

The recommended dosage for following condition as follows :
Dose after disease progression on or intolerance to imatinib mesylate
The usual dose for patients with Gastrointestinal Stromal Tumor is 50 mg PO qDay for 4 weeks, followed by 2 weeks drug-free, repeat cycle
The usual dose for patients with Renal Cell Carcinoma is 50 mg PO qDay for 4 weeks, followed by 2 weeks drug-free, repeat cycle
Adjuvant treatment of RCC :
• used for the adjuvant therapy of adult patients at high risk of recurrent RCC following nephrectomy
• The recommended dose is 50 mg PO qDay for 4 weeks, followed by 2 weeks drug-free, repeat cycle for a maximum of nine 6-week cycles totally
The usual dose for patients with Pancreatic Neuroendocrine Tumor
is 37.5 mg PO qDay continuously without a scheduled off-treatment period

MECHANISM

Sunitinib belong to type of small molecule which prohibits multiple RTKs, some of which are involved in tumor growth, pathologic angiogenesis, and metastatic progression of cancer. Sunitinib was judge for its inhibitory activity against a variety of kinases (>80 kinases) and was identified as an inhibitor of platelet-derived growth factor receptors (PDGFRa and PDGFRb), vascular endothelial growth factor receptors (VEGFR1, VEGFR2 and VEGFR3), stem cell factor receptor (KIT), Fms-like tyrosine kinase-3 (FLT3), colony stimulating factor receptor Type 1 (CSF-1R), and the glial cell-line derived neurotrophic factor receptor (RET)

ADME

High plasma concentration of sunitinib is between 6 and 12 hours and the bioavailability of sunitinib has no effect on food.
Human plasma protein binding was 95 % and 90 % respectively.
Primarily metabolized by cytochrome P450 enzyme, CYP3A4
The drug sunitinib is eliminated primarily through feces 61% and renal excretion is 16% of administrated dose. Sunitinib half-life is 40 – 60 hours
Primary active metabolite half-life was 80 – 110 hours

PRECAUTION

• Adrenal haemorrhage resulted in animal studies; follow the adrenal function in case of stress such as surgery, trauma or severe infection
• Control urine protein; interfere with treatment for 24-hr urine protein ≥3 g; stop for repeat episodes of protein ≥3 g despite dose reductions or nephrotic syndrome
Sutent 12.5mg treatment will causes severe hepatotoxicity involving liver failure; check liver function tests before starting treatment.
• Haemorrhagic events involving tumor-related haemorrhage resulted; test the serial complete blood counts and physical examinations
• Hypothyroidism resulted; follow the baseline thyroid function in patients with hypothyroidism or hyperthyroidism and treat per standard medical practice prior to initiating therapy

DRUG INTERACTION

Sutent 12.5mg combination with CYP3A4 inhibitors (ketoconazole0 will increase the sunitinib plasma concentrations.
Sutent 12.5mg combination with CYP3A4 inducers (rifampin) will decrease Sunitinib plasma concentration

CONTRAINDICATION

Patients are contraindicated with Sutent 12.5mg due to hypersensitivity and renal impairment.

MISSED DOSE

If dose is missed the have the dose immediately before next dose timing reaches or skip the missed dose and continue the regular schedule.
Consult doctors regarding missed dose.

STORAGE

Stored at controlled temperature at 25℃ Keep away from children’s resistance Dispense only in its original carton

SIDE EFFECTS

Common side effects :
Signs of allergic reactions: hives, breathing difficulty, sore throat, skin pain, red or purple skin rash Liver problem: upper stomach pain, itching, tried feeling, decreased appetite, dark urine, jaundice.
Serious side effects :
Swelling in ankles or feet
Fast heart beats
Sudden dizziness
Shortness of breath
Unusual bruising
Signs of tumor cell breakdown - muscle cramps, tiredness, decreased urination, slow heart rate. Thyroid problem - severe tiredness, depression, rapid heart rate, , feeling nervous, sweating, nausea, vomiting, diarrhea, loss of hair, weight changes, irregular menstrual periods.

We'd Like to Hear From You!

PRESCRIPTION POLICY

1. myapplepharma.com, a fully licensed and regulated pharmacy, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.
2. myapplepharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.
3. If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.
4. The drug information provided in the myapplepharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.
5. myapplepharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from myapplepharma.com.
6. At myapplepharma.com, a Caregiver can order prescription medicines on your behalf.


This information should not be used to decide whether to accept this product or any other medicine. Only a health care provider is knowledge and training to decide that a medicine suitable for a specific patient. This information does not support any drug as safe, are effective or approved for the treatment of any patient or health condition. It's simple a brief overview of general information about this product. It does not include all information on possible applications, indications, warnings, precautions, interactions, adverse effects or risks that may be relevant to this product. This information is not specific medical advice and does not replace information obtained from your health care provider. You should check with your health care provider for complete information about the risks and benefits of using this product.