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PRODUCT DETAILS

Generic : Tamoxifen
Trade name : Tamtero
Strength : 10mg
Manufactured by : Hetero drug Ltd
Packing : Pack of 30 tablets

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Tamtero 10mg is belongs to the anticancer agents and covered by film coated tablet, the drug also anonsteroidal antiestrogen and work as a modulator with tissue selective activities for the treatment.
Tamtero 10mg as a stimulating agent (estrogen) in metabolism of cholesterol, bone density, and cell replication in the endometrium.Tamtero 10mg will help for inhibition of estrogen receptor positive cancer.

INDICATION

Tamtero is usedto treat of early breast cancer in women whose been already treated with surgery, radiation, and chemotherapy.
Tamtero will help to reduce the risk of developing a more serious type of breast cancer in women who had breast cancer that will not spread outer part of the milk duct where it forms(ductal carcinoma).

DOSAGE

Regular adult dose for :
20 to 40mg for 5 years daily administer orally for breast cancer doses is > 20mg given by dividing dose (morning and evening) 20mg 5 years daily given orally for DCIS followed by surgery and radiation on breast
For 5 years administer20mg daily taken orally to decrease the action of breast cancer in women at increased risk for breast cancer 20mg OD orally or 10mg twice daily orally given for adult dose for adjuvant breast cancer and Duration: 5 years
Pediatric dose for:
girls 2 to 10 years :
20mg once daily via oral route; duration up to 12 months administrated for McCune- Albright syndrome
20mg once daily via oral route; duration up to 12 months given for Precocious Puberty

MECHANISM OF ACTION

Cytotam is a type of nonsteroidal agent which interlinked to estrogen receptors (ER), provoke a conformational change in the receptor. This results in a inhibits in the verbalization of estrogen based on genes.
Combine ofTamtero is extended to the nuclear chromatin of these consequence will reduced DNA polymerase action, repair thymidine discharge and restrictionuptake of estradiol, hencelowers estrogen response.
Tamteroenough that to concomitant with other co activators or co repressors in the tissue and fuse with different estrogen receptors.

PHARMACOKINETICS

Absorption :
The time to high plasma concentration is 40mg/ml and Tmax is 5 hours after dosing.
Distribution:
not available
Metabolism:
In hepatic Tamtero is metabolized.
Elimination:
Route of excretion is 30% via fecal and 65% was excreted from the body Half life is 5 to 7 days

PRECAUTION

Consult with the doctor or pharmacist as if you have allergic condition against Tamtero or any of the compound in Tamoxifen tablets.
Consult withthe doctor that you have or have ever had renal, hepatic, or cardiac problem
Consult withthe doctor that are you pregnant or plan to become pregnant. Do not have planfor children while on treatment with Tamtero. You must use a specific method of conceiving to prevent pregnancy in yourself or your partner during your treatment with Tamterothe drug will harm the fetus.
Avoid breast feeding while on treatment with Tamtero
Use drug with caution due to early breast cancer signs hence during treatment with tamoxifen aware about development of breast cancer.
Some important precautions should take care
Effects in Metastatic breast cancer Patients
Some breast cancer patients may report from hypercalcemia by starting few weeks treatment, if the condition occur and became severe then tamoxifen should discontinue.
Effects on the Uterus-Endometrial Cancer and Uterine Sarcoma
An incidence may increase with uterine malignancies and endometrial carcinoma is resulted with tamoxifen treatment.
Non-malignant Effects on the uterus
Due to estrogen properties of tamoxifen, an increased incidence of endometrial changes occurs involves like hyperplasia and polyps has been resulted. Hence the drug causes menstrual irregularity or amenorrhea.

DRUG INTERACTION

While interaction of Tamtero 10mg with coumarin type anticoagulants combination will leads to increase in anticoagulant effects may occur.
Concomitant use of Bromocriptine with Tamtero 10mg will increase the serum level of Tamtero and N-desmethyl tamoxifen.

CONTRAINDICATION

Tamtero 10mg is contraindicated in patients with as follows:
• Known hypersensitivity to the drug or its any ingredients
• Women concomitant use with coumarin- type anticoagulant treatment
• In women with deep vein thrombosis or pulmonary embolus history.

STORAGE

Keep away from children
Do not freeze
Keep the drug in a closed container at room temperature.

MISSED DOSE

Have the missed dose immediately before next dose duration
Next dose time arrived then left off the missed dose and follow regular schedule.
Avoid takingextra dose at same time.
Please consult the doctor for further details.

SIDE EFFECTS

COMMON SIDE EFFECT :
• High tumor pain
• Tumor site forming reddening
• Hair thinning
• Weight loss
• Stomach pains
• Sexual ability lost
• Hot flashes
• Vertigo
Serious side effects may be as follows, immediately inform the doctor :
• Thirst
• muscle weakness
• restlessness
• loss of appetite
• Vision difficulty
• Fever
• Blisters
• Abscess on the,throat, face,lips,eyes, tongue,ankles or lower legs.

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