Brand Name : Tenvir
Active components : Tenofovir Disoproxil Fumarate
Strength of the components : 300mg
Manufactured by : Cipla
Category : Anti-hepaciviral & Anti-retro viral agent
Package : 30 tablets in a container


Tenofovir Disoproxil Fumarate Tenvir is a cipla product which is FDA approved product, containing anti-viral activity against both HIV infection and HBV infection. Tenvir is a most dominant, first line therapy used by the patients only under the knowledge of medical practitioner who are well trained


Tenvir tablets are primarily indicated in the conditions like :
HIV infection :
In HIV infection, Tenvir tablet is not used alone it may combined with other anti-retroviral medicines (like NNRTI or PI)
Chronic hepatitis B infection :
Tenvir is used in the treatment of severe hepatitis B viral infection mainly in adults


Tenofovir disoproxil fumarate is a prodrug which is converted into an active form tenofovir in-vivo. The oral bioavailability of Tenvir tablet is reaches relatively at 25% The peak serum concentration occurs within 1.0 hours ± 0.4 hours Binding of tenofovir with human plasma protein or serum proteins is occurred in-vitro as less than 0.7% & 7.2% respectively The volume of distribution occurs at steady state 1.3±0.6L/kg The metabolism of Tenvir tablet occurs hepatically to form active tenofovir diphosphate which is pharmacologically active form with the help of cellular enzymes The terminal half life period of Tenvir occurs nearly 17 hours The effect of food with Tenvir tablet on oral administration, with high fat meals increase the oral bioavailability at 40 to 50%


Tenvir is used as a single dose regimen Tenvir tablets should be taken with or without food Tenvir tablets recommended dosage in the conditions like HIV-1 & HBV infections; In adults & pediatric around the age of 12 years or weight of 35kg or more in hepatitis B infection and 2 years of age in HIV condition; One Tenvir tablet 300mg should be administered orally as a single dose with or without food The dosage of Tenvir should be calculated on the basis of creatinine clearance value and body weight of the patients In renal impairment patients, hemodialysis occurs weekly three sessions around 4 hours. Tenvir tablets should be taken only after conclusion of dialysis

Depending on body weight of pediatrics

17 to <22kg: 150mg , 22 to <28kg: 200mg , 28 to <35: 250mg , ≥35kg: 300mg.
In adults: Depending on creatine clearance; ≥50ml/min: 300mg of Tenvir should be given every 24 hours 30 to 49ml/min: 300mg should be recommended for every 48 hours 10 to 29 ml/min: 300mg recommended dosage for every 72 to 96 hours In hemodialysis patients: Tenvir tablets should be taken every 7 days or after 12 hours of dialysis


Tenvir comprises of tenofovir disoproxil fumarate (TDF), acyclic nucleoside phosphonate diester analogue of adenosine monophosphate TDF desires initial diester hydrolysis for alteration of TDF into tenofovir Tenofovir is a parent compound, which is further phosphorylated into tenofovir diphosphate with the support of cellular enzymes. This active metabolite tenofovir diphosphate acts as chain dominator Tenvir exhibits its activity by insertion of tenofovir diphosphate into viral DNA and prohibits the effect of HIV-1 & HBV reverse transcriptase against the natural substrate deoxyadenosine 5’-triphosphate after insertion


In lactic acidosis or serious hepatomegaly with steatosis: To avoid this problem, patient must discontinue the therapy or postpone Severity of hepatitis B infection after conclusion of therapy: Patients who are discontinue the therapy, should be monitored frequently Continue the therapy if required Aggravation of renal impairment Mostly tenofovir is eliminated renally; creatinine clearance must be monitored periodically before starting the treatment Serum phosphorus, renal protein, creatine clearance, urine glucose values should be monitored before begin the therapy Avoid concurrent use of Tenvir with drugs which reduce the renal function or nephrotoxic agents Care should be taken while using in patients who are co infected with HIV-1 & HBV Major adverse effect is bone mineral density depletion, may leads to osteoporosis to avoid this condition calcium and vitamin D supplements should be provided Mineralization defects occurs


Tenvir containing active component tenofovir disoproxil fumarate interacts with some drugs and produce adverse effects Tenvir tablet concomitant with Didanosine, while receiving these drug at same time may produce some adverse effects related to Didanosine to avoid this problem stop the Didanosine tablet immediately While concurrent use of Tenvir with HIV 1 protease inhibitor, increases the concentration of tenofovir Tenvir is a substrate of P-gp & BCRP transporters, whereas co administration of Tenvir with P-gp inhibitors may increase the absorption Tenvir with Lopinavir/ritonavir, ritonavir boosted atazanavir or ritonavir boosted darunavir should increase the tenofovir associated adverse effects Tenvir co administered with hepatitis C anti-viral agents may have a chance to increase the tenofovir exposure Tenvir is excreted through renal, if Tenvir tablet concomitant with drugs which decrease the renal function may elevates the serum concentration of tenofovir disoproxil fumarate. Some examples like acyclovir, cidofovir, valganciclovir, valaciclovir, amino glycosides


Tenvir tablets used patients have chance to get; Lactic acidosis & severe hepatomegaly with steatosis After therapy, there is a chance of getting severe worsening of HBV viral infection


Tenvir tablet should be used only under the guidance of medical practitioner, if patient fail to take the dose of Tenvir tablet, must consult the physician and take the dose as soon as possible Otherwise the missed dose should be discontinued and follow the regular dosing schedule Do not take over dose


Tenvir tablet have no contraindication But some hypersensitivity reaction may occur if patients are contraindicated to the component of Tenvir tablet


Some undesirable effects occur during or after the therapy; Immune restructuring syndrome
Serious acute aggravation of hepatitis B infection
New outbreak of renal impairment
Depletion of bone mineral density
Lactic acidosis or serious hepatomegaly with steatosis.
Some common effects; Headache, Pain, Fever, Abdominal pain, Back pain, Asthenia, Diarrhea, Nausea, Dyspepsia, Vomiting, Arthralgia, Myalgia, Depression, Insomnia, Dizziness, Anxiety, Lipodystrophy, Pneumonia, Rashes.

We'd Like to Hear From You!


1., a fully licensed and regulated pharmacy, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.
2. will not dispense any prescription medication without a valid prescription from a licensed physician.
3. If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.
4. The drug information provided in the is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.
5. requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from
6. At, a Caregiver can order prescription medicines on your behalf.

This information should not be used to decide whether to accept this product or any other medicine. Only a health care provider is knowledge and training to decide that a medicine suitable for a specific patient. This information does not support any drug as safe, are effective or approved for the treatment of any patient or health condition. It's simple a brief overview of general information about this product. It does not include all information on possible applications, indications, warnings, precautions, interactions, adverse effects or risks that may be relevant to this product. This information is not specific medical advice and does not replace information obtained from your health care provider. You should check with your health care provider for complete information about the risks and benefits of using this product.