BRAND : Veenat
STRENGTH : 400mg
COMPANY NAME : Natco pharmaceuticals
TAB COUNT : 28 tablets in a container
Veenat 400mg is a antineoplastic agents and used by alone regimen or together with other medicines for the treatment of different types of cancer or bone marrow conditions, the main ingredient which is used as imatinib . Veenat 400mg will prevents the development of cancer cells in the body. Veenat 400mg is manufactured by Natco Pharma Ltd with 120 capsules in a container. Veenat 400mg strength available is 400mg, 100mg.
Chronic myeloid leukaemia
• Chronic phase:
The patients with Chronic phase the drug administrated 400 mg per day, given up to 600 mg/day or 400 mg bid if needed. The patients with Blast crisis or accelerated phase administrated 600 mg per day, up to 400 mg bid if required. Acute lymphoblastic leukaemia :Dose of 600 mg per day with induction, consolidation or maintenance therapy ; Monotherapy in relapsed or refractory acute lymphoblastic leukaemia 400 mg per day up to 400 mg bid is administrated for Unresectable, metastatic GI stromal tumours 400 mg/day. starting with100 mg/day in patients w/ith FIP1L1-PDGF-α fusion kinase is given for Hypereosinophilic syndrome
MECHANISM OF ACTION
Imatinib is a protein-tyrosine kinase inhibitor which inhibits the Bcr-Abl tyrosine kinase, the constitutive abnormal tyrosine kinase created by the Philadelphia chromosome abnormality in chronic myeloid leukemia (CML).
Myelodysplastic disease: 400 mg per day.
Mastocytosis 400 mg per day. starting with100 mg/day if there is analog eosinophilia.
Dermatofibrosarcoma protuberans: 400 mg bid.
Veenat 400mg should be taken with food by oral route.
Veenat 400mg is a antineoplastic drug which inhibits the growth of cancer cells and bone marrow condition. Veenat 400mg is also knowns as tyrosine kinase inhibitor that interferes with the BCR-ABL tyrosine kinase produced by the Philadelphia chromosome abnormality in chronic myeloid (blood cancer) leukaemia(CML). It stops the multiplication and induces suppress in BCR-ABL positive cell lines, thereby leukaemic cells from Philadelphia chromosome positive CML. Veenat 400mg also prevent receptor kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF), c-kit, PDGF- and SCF-mediated cellular effects.
rapid and complete absorbed from the GI tract. Bioavailability of Veenat 400mg is Approx 98%. Duration of peak plasma concentration: 2-4 hr.
Plasma protein binding of Veenat 400mg Approx 95%.
Veenat 400mg metabolized in CYP3A4 isoenzyme and to a lesser extent through CYP1A2, CYP2D6, CYP2C9 and CYP2C19 isoenzymes.active metabolite of Veenat 400mg is N-demethylated piperazine derivative.
excreted via faeces (68%) and urine (13%) within 7 days; excreted mainly as metabolites, with 25% as unchanged drug. Elimination half-life: Approx 18 hr Veenat 400mg and approx 40 hr (N-demethylated piperazine derivative).
BEFORE USE OF Veenat 400mg
CARE TO BE TAKEN
While taking Veenat 400mg, Inform your doctor about previously taking medicine involved in prescription and non prescription, over the counter, vitamins, herbal, nutritional supplements.
• Do not consume the aspirin, or products containing aspirin until doctor specifically permit may decrease the effectiveness of this medication.
• Acetominophen (Tylenol®) may not be recommended. Inform your doctor
• Before starting this treatment.discuss with health care professional if you are pregnant or chance of to be pregnant
• Both of the men and women: avoid conceive a child (get pregnant) while on treatment with Veenat 400mg. Barrier methods of contraception, such as condoms, are recommended. Inform the consultants , it will be safe to become pregnant or conceive a child after treatment.
• Avoid breast feed while on medication therapy.
Veenat 400mg+ CYP3A4 inhibitor( azole antifungal, macrolide) → increased serum levels Veenat 400mg + CYP3A4 inducers → reduced serum concentration Food interaction: with grape fruit Veenat 400mg reduce serum levels.
Hypersensitivity and lactation contraindicated with Veenat 400mg
if a single dose is missed, have the drug probably soon Next dose time reaches then leave the missed dose and continue the regular schedule Please consult with the doctor.
Veenat 400mg store below 30℃. Store in a tight container, protected from sunlight, moisture and freezing Keep out of the children’s Discard the drug after the expiry date. Dispose the unused drug by asking to the Pharmacist.
The following side effects of Veenat 400mg occurring in >30% for patients
• Low RBC,WBC and platelets: May increased risk for infection, anemia or bleeding; Nausea and vomiting; Swelling of the face, feet, hands (edema) ; Muscle cramps and bone pain; Diarrhea; bleeding problem; Skin rash; Fever.
Less common side effects of Veenat 400mg
• Dyspnea; fatigue; athralagia; stomach cramping; heartburn; cold; decreased appetite; constipation, night sweat; weakness; problems in fertility
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