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xbira-250mg

PRODUCT DETAILS

Generic : Abiraterone acetate
Trade name : Xbira 250mg
Manufactured by : Cipla Pvt ltd
INGREDIENT : abiraterone-acetate-Xbira-250mg
Container : 120 tablets

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Abiraterone is sold under brand name Xbira, the main ingredient which is used as abiraterone . Xbira is belongs to type of anti-cancer medicationthat will act by decline the androgen production in the body. Androgen is a male hormone that canmaintance the tumor cell in prostate glands. Actually thisdrug is given by co administration with prednisolone, a steroid which reduce the liability of side effects produced by Abiraterone.

DOSAGE

The prescribed dose of Xbira is initial as 4 tablets given orally once daily. The drug Xbira administrated combinationwith 5mg prednisolone twice daily in empty stomach. Xbira Tablets given on an empty stomach. Foodshould not be taken for at least 2 hours before and at least 1 hour after the dose of Xbira Tablets is taken. Swallowedwhole with water. Chew the tablets or Do not crush

MECHANISM OF ACTION

Androgens are balancethe production of malignant in prostate. Xbira (abiraterone acetate) is belongs to anti androgen drugs, thatcauses to suppress the enzyme 17α-hydroxylase C 17, 20-lyase (CYP17), it is involves in androgen conglomerate. Reduce the serum testosterone level. Declined the tumor cell occurred.

PHARMACOKINETICS

Absorption:
Time to maximum plasma concentration of Xbira tablet takes 12 hours.
Distribution:
Maximum bound to the human plasma protein like albumin and alpha-1 acid glycoprotein.
Metabolism:
Themain two metabolites of Abiraterone in human plasma are Abiraterone sulphate and N-oxide Abiraterone sulphate.
Excretion:
The drug mainly excreted in 88% feces and 5% in urine Half-life of tablet Xbira is 12 ± 5 hours.

MISSED DOSE

If patient missed the dose ofXbira, that missed dose will be skipped and follow the regular dosing schedule.

OVERDOSAGE

Xbira has no essential antidote, If overdose occurs end treatment with the drug and give general supportive measures such as monitoring arrhythmias and cardiac failure and assess liver function.

DRUG INTERACTION

Interaction ofXbira with dextromethorphan will raises the Cmax and AUC of dextromethorphan Interaction Xbira with strong CYP3A inhibitors or inducers , concomitant use with caution because pharmacokinetics is not evaluated.

SIDE EFFECTS

Common effects :
Fatigue, Arthralgia, Hypertension, Nausea, edema, Hypokalemia, Diarrhea, vomiting, Cough, headache, Glucocorticoid deficiency,Mineral corticoid deficiency, Hepatotoxicity, Hypertension, Decrease in ka level, Adrenocortical insufficiency Musculo skeletal and Connective tissue disorders:Joint swelling, discomfort, muscle discomfort General Disorder:Oedema
Cardiac disorders:Hot flush, hypertension, arrhythmias, chest pain, cardiac failure
GIT disorders:Diarrhea, dyspepsia
Infections and Infestation:UTI
Pulmonary disorder:Cough
Renal:Urinary frequency, nocturia
Injuries:Fractures

STORAGE

The drug stored at 15℃-30℃ Keep the drug in dry place.

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