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PRODUCT DETAILS

Brand Name : Xovoltib
Composition : Afatinib
Strength availability : 40mg
Manufactured by : Boehringer
Pack : 7 tablets in a strip
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Xovoltib 40mg belongs to quinazoline and butanamide derivative which acts as a tyrosine kinase inhibitor of epidermal growth factor receptors (ERBB RECEPTORS) and is used in the treatment of metastatic NON-SMALL CELL LUNG CANCER.
Xovoltib 40mg is a prescription drugs which is used under the guidance of medical practioners.

INDICATION

Xovoltib 40mg is indicated for treatment a certain type of lung cancer (non-small cell lung cancer) which has spread to other parts of the body.

DOSAGE

Xovoltib the prescribed dose for the treatment of non-small cell lung cancer as follows :
For adult :
The prescribed dose is 40mg taken once per day.
For child dosage :
Ages of 0-17 years is not being studied in children.
The drug should not be used age under 18 years of age
For renal impairment:
prescribed dose is 30mg taken once per day
Take Xovoltib on an empty stomach. Consume the drug 1 hour before or 2 hours after a meal
Avoid cutting or crushing the tablet.

MECHANISM

Xovoltib 20mg blocking the activating sites called tyrosine kinases of various proteins within the cell. These proteins are most likely to develop cancer growth when the tumor includes the EGFR gene mutation. By stopping these targets, it will target the cancer will shrink.

PRECAUTIONS

Diarrhae:
mostnormal condition for people administrating this drug to have diarrhea. Certain situation this diarrhea can be serious. Severe diarrhea can cause dehydration and renal problems which can sometimes lead to death. During your treatment with Xovoltib 40mg, your doctor should also to treat diarrhea primarily.
Hepatic toxicity : Xovoltib 40mg can worsen liver problems. Doctor will take blood tests to monitor the liver function before and during your treatment with this drug.
Keratitis: if patients confirm with suspected keratitis or ulcerative keratitis then stop or discontinue the drug
Interstitial lung disease (ILD) : Xovoltib 40mg drug can leads to lung and breathing problems. Inform doctor right away about new or worsening lung problems while taking this drug. These problems can involveDyspnea, cough, or fever.
Bullous and exfoliative skin disorder : Xovoltib 40mg can affect skin severely and show redness, rash, and acne. Inform doctor right away if you affected by severe skin reactions such as peeling or blistering.
Embryo-fetal toxicity:
Xovoltib 40mg will cause harm to the foetus when administrated to pregnant women.

DRUG INTERACTION

Concomitant of Xovoltib 40mg with P-gpinhibitors (cyclosporine A, ketoconazole verapamil) will increase exposure to Afatinib
Interaction of Xovoltib 40mg with P-gpinducers (carbamazepine, phenytoin, phenobarbital) will decrease exposure to Afatinib

STORAGE

Xovoltib 40mg Store at 25℃.
Keep Xovoltib 40mg away from children.

MISSED DOSE

If patient missed to take the dose of Xovoltib 40mg,the missed dose should be skipped and follow the regular dosing schedule. Do not self-medicate. Do not double the dose.

SIDE EFFECTS

• Loss of appetite
• Nausea
• Vomiting
• Diarrhoea
• Mouth sores
• Acne
• Itchiness
• Rash
• Dry skin
• Nail infection
Serious side effects :
• Breathing trouble
• Cough and fever
• Yellowing the skins
• Brown coloured urine
• Bleeding or bruising
• Weakness
• Blurred vision
• Fast heartbeat

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This information should not be used to decide whether to accept this product or any other medicine. Only a health care provider is knowledge and training to decide that a medicine suitable for a specific patient. This information does not support any drug as safe, are effective or approved for the treatment of any patient or health condition. It's simple a brief overview of general information about this product. It does not include all information on possible applications, indications, warnings, precautions, interactions, adverse effects or risks that may be relevant to this product. This information is not specific medical advice and does not replace information obtained from your health care provider. You should check with your health care provider for complete information about the risks and benefits of using this product.