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PRODUCT DETAILS

Generic : Abiraterone acetate
Trade name : Zelgor
Strength : 500mg
Container : 120 tablets
Manufactured by : Sun Pharmaceuticals Ltd

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Abiraterone is sold under brand name Zelgor 500mg
Zelgor 500mg is belongs to type of anti-cancer medication that will act by decline the androgen production in the body.
Androgen is a male hormone that can maintained the tumor cell in prostate glands.
This drug is given by co administration with prednisolone, a steroid which reduce the liability of side effects produced by Abiraterone.

DOSAGE

The prescribed dose of Zelgor is initial as 4 tablets given orally once daily.
The drug Zelgor administrated combination with 5mg prednisolone twice daily in empty stomach.
• Zelgor Tablets given on an empty stomach.
• Food should not be taken for at least 2 hours before and at least 1 hour after the dose of Zelgor Tablets is taken. • Swallowed whole with water. • Chew the tablets or Do not crush

MECHANISM OF ACTION

Androgens are balance the production of malignant in prostate.
Zelgor 500mg belongs to anti androgen drugs, that causes to suppress the enzyme 17α-hydroxylase C 17, 20-lyase (CYP17), it is involving in androgen conglomerate.
Reduce the serum testosterone level.
Declined the tumor cell occurred.

PHARMACOKINETICS

Absorption:
Time to maximum plasma concentration of Zelgor 500mg tablet takes 12 hours.
Distribution:
Maximum bound to the human plasma protein like albumin and alpha-1 acid glycoprotein.
Metabolism:
The main two metabolites of Abiraterone in human plasma are Abiraterone sulphate and N-oxide Abiraterone sulphate.
Excretion:
The drug mainly excreted in 88% feces and 5% in urine
Half-life of tablet Zelgor 500mg is 12 ± 5 hours.

SAFETY AND WARNING

Any allergy, serious liver problem or pregnant in patient, Zelgor 500mg therapy should be stopped Avoid taking of other medications, i.e. prescription, over-the-counter, vitamins, herbal remedies, etc. be sure to inform the doctors before the treatment.
Do not take Aspirin administrated and products containing aspirin till doctor particularly allow the drug.

DRUG INTERACTION

Interaction of Zelgor 500mg with dextromethorphan will raises the Cmax and AUC of dextromethorphan Interaction Zelgor 500mg with strong CYP3A inhibitors or inducers, concomitant use with caution because pharmacokinetics is not evaluated.

STORAGE

The drug stored at 15℃-30℃ Keep the drug in dry place.

MISSED DOSE

If patient missed the dose of Zelgor 500mg, that missed dose will be skipped and follow the regular dosing schedule.

SIDE EFFECTS

Common effects :
Fatigue, Arthralgia, Hypertension, Nausea, edema, Hypokalemia, Diarrhea, vomiting, Cough, headache, Glucocorticoid deficiency, Mineral corticoid deficiency, Hepatotoxicity, Hypertension, Decrease in ka level, Adrenocortical insufficiency Muscular skeletal and Connective tissue disorders: Joint swelling, discomfort, muscle discomfort
General Disorder: Edema
Cardiac disorders: Hot flush, hypertension, arrhythmias, chest pain, cardiac failure
GIT disorders: Diarrhea, dyspepsia
Infections and Infestation: UTI
Pulmonary disorder: Cough
Renal: Urinary frequency, nocturia
Injuries: Fractures.

OVERDOSAGE

Zelgor 500mg has no essential antidote, If overdose occurs end treatment with the drug and give general supportive measures such as monitoring arrhythmias and cardiac failure and assess liver function.

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