Trade name : Zepdon
Active ingredient : Raltegravir
Strength availability : 400mg
Manufactured by : Cipla
Package : 60 tablets in a container
Category : Anti-retroviral drug.


Raltegravir is chemically sort by type as derivative of pyrrolidinone. Zepdon tablets are belongs to as anti-retroviral medicine by involving an active ingredient known as Raltegravir which is efficient against HIV infection. Zepdon tablets are pharmacologically classified as an inhibitor of integrase. Zepdon may used in Co-administration with other anti-retroviral drugs for producing beneficial activity. Zepdon tablets are prescription regimen, which is used only under guidance of medical practitioner.


Zepdon tablets are indicated to treat of HIV-1 infection by concomitant use with other anti-retroviral medicines. Hence the evidence is based on investigating the plasma HIV-1 RNA levels. The usage of Zepdon is based on evalution of safety, tolerability, pharmacokinetic parameters & efficacy of Raltegravir.


Isentress tablet should be taken with or without food. Zepdon tablet should be taken with or without food. In adult, the usual dose is 400mg of Zepdon should be given as a two times a day. In pediatrics; 12 years or older: The usual dose is 400mg of Zepdon should be consumed as two times a day. 6 to less than 12 years of age: At least 25kg: One tablet of Zepdon 400mg should be taken orally administer as two times a day ≥ 40kg: the drug Zepdon 400mg should be administered two times a day.


Zepdon consist of Raltegravir targeted the integrase which is an enzyme that assimilate the viral genetic material into human chromosome, a demanding step in HIV pathogenesis.


Absorption: high plasma concentration time is almost 3 hours.
Distribution: Raltegravir is largely bound to human serum protein by 83%. The drug is dispersed in red blood cells at minor range.
Metabolism :
Majorly in liver metabolism of Zepdon is occurs
Excretion :
The Raltegravir excretion route is occurs through feces & urine. The Raltegravir half life period is 9 hours.


Immune reconstitution syndrome: This lethal condition is generally occurred in patients who are receiving anti-retroviral treatment. Give safety measures In severe condition, stop the treatment. Phenylketonurics: Raltegravir is a chewable medication which consist of a component like phenylalanine (aspartame component) which is responsible for this fatal case. Severe skin reactions & anaphylactic reactions: Skin reactions like Stevens Johnson syndrome & toxic epidermal necrolysis are some of fatal cases occur. Provided life threatening condition, therapy should be discontinue and provide the general supportive therapy. Clinical wise status should be suitably monitored for decreasing the manifestations.


Interaction with atazanavir causes increasing the concentration of Raltegravir. The drug Raltegravir is not prevents the CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 or 3A. Raltegravir not prevents the P-gp mediated transport. Zepdon tablets are interaction with rifampin leads to depletion of plasma concentration of Raltegravir. In case of this consolidation, the dose of Zepdon should be increased for lowering this adverse problem. Interaction of Zepdon with atazanavir/ritonavir, causes increasing concentration of Raltegravir Concurrently use of Zepdon tablets with Efavirenz leads to cause decreasing the concentration of Raltegravir. Interaction of Zepdon tablets with tipranavir/ritonavir, causes deminish the effect of concentration of Raltegravir. Co administration with gastric regulators should be avoided, because this combination leads to increase the effect of concentration of Raltegravir.


The highest dose of Zepdon is 1600mg as a single dose The highest dose of Zepdon is 800mg as two times a day. Even if over dosage of Zepdon occur patient must be; Start with supportive measures and excrete the unabsorbed dose from GI tract. Monitor the manifestation occurs due to over dosage


Zepdon is an anti-retroviral medicine, On condition of missed dose, the patient should be consult with medical practitioner and maintain the guidance Or skip missed dose and Maintain the regular dosing schedule


While using with drug most people affect with some side effect. Some of them are listed below :
Decreased in platelets count Elevation of blood glucose level Increased bilirubin Increased serum AST, ALT Increased alkaline phosphatase Insomnia Abnormal dreams Fatigue Neutropenia Anemia Headache Nausea Asthenia Abdominal pain Gastritis Hepatitis Hypersensitivity Stevens Johnson syndrome Herpes zoster Dizziness Renal failure Suicidal ideation Rash

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