Ramiven 100 Tablet

Description of Ramiven 100 (Abemaciclib 100mg) tablet

Abemaciclib is an oral anticancer agent used in the treatment of particular subtypes of breast carcinoma among adult patients. It belongs to the family of Cyclin−Dependent Kinase 4 and 6 (CDK4/6) inhibitors, which has the antineoplastic action of selectively inhibiting the activity of the enzymes that stimulate deregulated cell growth. The drug inhibits the growth of the tumour and disease progression in the hormone-receptor-positive (HR+) breast cancer by blocking these signalling pathways.

Indications of Ramiven 100 (Abemaciclib 100mg) tablet

The main indications of Abemaciclib include the use of the drug in the treatment of Hormone receptor plus (HR+), HER2 negative (HER2 -) advanced or metastatic breast cancer combined with endocrine treatment (aromatase inhibitor or fulvestrant). It is used where the progression of the disease has already taken place after hormone therapy or first-line metastatic case, depending on the evaluation of the physician.

Mechanism of action of Ramiven 100 (Abemaciclib 100mg) tablet 

Abemaciclib is a selective inhibitor of the Cyclin-Dependent Kinase (CDK4/6) which play a crucial role in the progression of the G1 to the S phase in cells. Blocking of these kinases inhibits the process of phosphorylating retinoblastoma protein (Rb) and causes cell cycle arrest in malignant cells and decreases their proliferation ability.

How to consume of Ramiven 100 (Abemaciclib 100mg) tablet

Patients are required to take Abemaciclib as prescribed by their clinician following the due schedule, dose, and duration. The drug is usually administered at a single dose, usually with food, at a similar time of day. Tablets should be swallowed entirely in water and they should not be crushed, chewed or broken. The treatment cycle typically goes through 21 days of consecutive administration followed by 7 days of no intake with the exception that it may be otherwise ordered by the physician.

Side Effects of Ramiven 100 (Abemaciclib 100mg) tablet

1. Common side effects

• Neutropenia
• Fatigue or weakness
• Mild diarrhea
• Nausea or vomiting
• Reduced appetite
• Oral mucositis

2. Serious side effects

• Cardiac dysfunction
• Infusion reactions
• Liver enzyme abnormalities
• Fatal anaphylactic reactions

3. Rare side effects

• Dermatologic reactions which are severe
• Muscle spasm
• Considerable dermatologic eruptions

Safety Advice for Ramiven 100 (Abemaciclib 100mg) tablet

Clinical monitoring of patients under the treatment of Abemaciclib is necessary, full blood counts (neutrophils, erythrocytes, platelets), a hepatic and renal functional evaluation periodically to detect the development of adverse effects at an early stage.

Breastfeeding: Abemaciclib should not be used in lactation, which may result in the breast milk excretion of the drug and the metabolites of the drug.

Pregnancy: Abemaciclib is contraindicated when pregnant and teratogenic. Females who are capable of giving birth must use effective birth control during the course of treatment and also meet with a clinician to be a advised.

Alcohol: Intake of alcohol should be limited since it could increase the effect of hepatotoxicity.

Liver: Patients who have a history of hepatic disorders must use Abemaciclib cautiously and with strict medical care as the drug may increase the level of hepatic enzymes.

Lungs: New cough, dyspnea and chest discomfort should be reported as soon as possible.

Kidney: Care should be taken in patients with severe renal failure.

Driving: It is possible that patients feel dizzy or fatigued, in this case the patients should avoid driving.

Interaction of Ramiven 100 (Abemaciclib 100mg) tablet

• Drug-Drug Interaction:

Aniodarone x Abemaciclib

Use alternative drug because the use of amiodarone will increase the effect of Abemaciclib by P-glycoprotein efflux transporter.

Riociguat x Palbociclin

Use alternative drug because the use of Abemaciclib will increase the effect of riociguat by decreasing it metabolism.

Dichlorphenamide x Abemaciclib

The combination should be used with caution as the interaction lowers the levels of serum potassium.

Siponimod x Abemaciclib

It is recommended that clinical vigilance be observed because the combination might increase the risk of infection.

• Drug-Food Interaction:

Food:

Thera is no reported food interaction that is significant however, a balanced diet should be maintained.

• Drug-Disease Interaction:

Lung toxicity:

The treatment plan must be used with a careful attitude in the patients with a history of interstitial pneumonitits because the drug may cause extreme pulmonary fibrosis. The drug should be stopped in case of the confirmed diagnosis of pneumonitis.

Congestive Heart Failure:

The medication must be used carefully in patients having a history of heart disease since consumption of this drug may lower the left ventricular ejection fraction.

Peripheral neuropathy:

The therapy should be administered with care, as it may cause the development of peripheral neuropathy.

Contraindication of Ramiven 100 (Abemaciclib 100mg) tablet

Abemaciclib should not be used in patients with the established hypersensitivity to the drug, and its use is not recommended in pregnant women. The drug should be administered with caution in patients who have severe hepatic impairment.

Dosage of Ramiven 100 (Abemaciclib 100mg) tablet

The dosage depends on the type of cancer, weight of the body and clinical response. Depending on tolerance and efficacy of therapy, the oncologist can modify treatment.

Storage of Ramiven 100 (Abemaciclib 100mg) tablet

Tablet of Ramiven 100 need to be kept somewhere with average room temperature conditions, protecting it from too much moisture or heat. You should always have them inside packet they are in and out of reach of children.

Missed Dose of Ramiven 100 (Abemaciclib 100mg) tablet

In case of a missed infusion, call the healthcare provider so as to reschedule. Do not give two ties its dose.

Other General Information of Ramiven 100 (Abemaciclib 100mg) tablet 

The long-term treatment can cause fatigue or xerosis, it is necessary to stay hydrated, have a balanced diet, and have frequent follow-ups. Any abnormal symptoms are to be reported immediately by patients and personal guidance provided by the clinician in charge.

FAQs of Ramiven 100 (Abemaciclib 100mg) tablet 

1. Why is heart monitoring important during Abemaciclib therapy?

Due to the possibility of Abemaciclib to diminish cardiac contractility, frequent cardiac assessment helps in the prompt identification of alterations. .

2. Can Ramiven 100 cause severe lung issues?

Yes, the use of this medicine may cause pleural effusion which leads to difficulty in breathing, chest pain, and cough. Kindly inform your doctor if you have developed this symptoms.

3. Does Ramiven 100 have any impact on breathing?

In some extreme cases, pulmonary inflammation can present. The clinician must be informed immediately on the occurrence of new onset cough, chest tightness, or dyspnea.

4. What about when one feels extremely tired or lightheaded?

It is advisable that the person should alert his doctor when he experiences such symptoms. The doctor will then alter the dose of the same.

5. Can I continue normal activities?

Yes, expect in the case of grave fatigue or light headedness.

Fact Box of Ramiven 100 (Abemaciclib 100mg) tablet:

References

• Abemaciclib [Prescribing Information]. Indianapolis, IN: Lilly USA, LLC; 2021. [Accessed 20 Feb. 2024] (online) Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/208716s006s007s008lbl.pdf
• Abemaciclib [Prescribing Information]. Madrid, Spain: Eli Lilly and Company (Ireland) Ltd.; [Accessed 14 Oct. 2025] (online)  https://www.ema.europa.eu/en/documents/product-information/verzenios-epar-product-information_en.pdf