Entax 20 Tablet

Description of Entax 20 (Tamoxifen 20 mg) tablet

One of the ingredients of Entax 20 tablet, called Tamoxifen, is an antineoplastic drug, and falls under the category of drugs known as selective estrogen receptor modulators ( SERMs ) category of drugs. It extensively finds use in the treatment and prevention of the hormone receptor-positive breast cancer. Tamoxifen is an estrogen antagonist of the breast tissue thus averting the growth of estrogen stimulated cancer cell in the breast tissue. In the meantime it may be a partial agonist of other tissues e.g. bone and endometrium.Such selective behavior renders it useful in minimizing tumor progression although retaining good bone density.

Indications of Entax 20 (Tamoxifen 20 mg) tablet

Some of the uses of Tamoxifen are the treatment of estrogen receptor-positive breast cancer, metastatic breast cancer and as a preventive agent to high-risk people against breast cancer.

Mechanism of action of Entax 20 (Tamoxifen 20 mg) tablet

Tamoxifen attaches to the estrogen receptor preventing the connection of the estrogen receptor towards the breast tissue. This inhibits growth of cancer cells, which happens due to the influence of estrogen. It can imitate to a certain extent estrogen, in other tissues and this is one of the reasons as to why it has both negative and positive effects.

How to consume Entax 20 (Tamoxifen 20 mg) tablet

It can be administered with or without food, but is best administered at the same time every day to be more effective.

Side Effects of Entax 20 (Tamoxifen 20 mg) tablet

1. Common Side Effects

• Hot flashes
• Nausea
• Fatigue
• Menstrual irregularities
• Vaginal discharge

2. Serious Side Effects

• Thromboembolic events
• Endometrial cancer
• Stroke
• Visual disturbances

3. Rare Side Effects

• Liver dysfunction
• Hypersensitivity reactions

Safety Advice for Entax 20 (Tamoxifen 20 mg) tablet

Tamoxifen affects other tissues and patients on Tamoxifen with both estrogenic and anti-estrogenic, should be under constant monitoring including gynecological examination and liver functioning tests.

Breastfeeding: Tamoxifen is not recommended during breastfeeding as it can cause disruption of hormonal possibility of the baby.

Pregnancy: Contracended, because this could result to the unborn baby contracting sickness because of the hormone disorders.

Alcohol: Although consuming alcohol is minimal, it can cause some of them such as dizziness and tiredness; hence, it is important to limit its consumption.

Liver: Since Tamoxifen is hepatically excreted, liver disease patients will need close monitoring to avoid accumulation and toxicity.

Lungs: Any sudden shortness of breath or chest pain needs to be reported immediately as it could be a symptom of pulmonary embolism.

Kidney: No kidney monitoring but the special attention should be followed in the case of unnaturally erroneous kidney activity.

Driving: Patients might become dizzy or have visual impairments, therefore, they should not drive due to any of the reasons.

Interaction of Entax 20 (Tamoxifen 20 mg) tablet

• Drug–Drug Interaction

Warfarin × Tamoxifen

Tamoxifen has the potential to increase the anticoagulant effect of warfarin and hence the risk of bleeding. INR should be carefully monitored.

Paroxetine × Tamoxifen

These medications block the action of CYP2D6 enzyme that is needed to transform Tamoxifen into an active drug. This makes Tamoxifen less effective and could cause the failure of treatment.

Aromatase inhibitors × Tamoxifen

The effects of Tamoxifen can be decreased by concurrent use as both drugs influence estrogen pathways in a different manner.

Ketoconazole × Tamoxifen

May augment Tamoxifen and chance of side effects.

Carbamazepine × Tamoxifen

May lower Tamoxifen concentration decreasing therapeutic efficacy.

• Drug–Food Interaction

It can be given with and without food although more effective when given at the same time on a daily basis.

• Drug–Disease Interaction of Entax 20 (Tamoxifen 20 mg) tablet

Thromboembolic disorders:

Tamoxifen makes the risk of blood clotting by altering the manner in which it will coagulate. Those who are at risk and those that have history of deep vein thrombosis or pulmonary embolism. Tamoxifen can modify the lipid metabolism and patients with lipid disorder require follow-ups.

Endometrial disorders:

Tamoxifen is a partial estrogen agonist within the uterus and which is capable of stimulating an endometrial growth and elevating the chances of endometrial cancer. The check-up of the gynaecology should be periodically.

Liver disease:

Tamoxifen is broken down by the liver and liver dysfunctions can cause an accumulation of tamoxifen and liver toxicity. The blood enzymes of the liver are advised to be monitored.

Hyperlipidemia:

Tamoxifen can modify the lipid metabolism and patients with lipid disorder need follow-ups.

Contraindications of Entax 20 (Tamoxifen 20 mg) tablet

Should not be used during pregnancy, a history of thromboembolic disorders and hypersensitivity.

Dosage of Entax 20 (Tamoxifen 20 mg) tablet

The usual dosage is 20-40 mg/day but the dosage depends on the condition and the patient response.

Storage of Entax 20 (Tamoxifen 20 mg) tablet

Store in dry, warm and damp free conditions.

Missed Dose of Entax 20 (Tamoxifen 20 mg) tablet

If missed dose take it as soon as possible. Do not double dose.

Other General Information of Entax 20 (Tamoxifen 20 mg) tablet

If any of the symptoms (abnormal bleeding, leg pains or breathlessness) are reported, this should be reported immediately.

FAQs of Entax 20 (Tamoxifen 20 mg) tablet

1. What is the mechanism of action of Tamoxifen that causes uterine cancer?

Since it is a partial estrogen agonist within the endometrium, it stimulates cell growth and elevates the risk of cancer at a prolonged use.

2. Why is it important to avoid SSRIs with Tamoxifen?

Since they block CYP2D6 enzyme, lowering the transformation of Tamoxifen to its active form and lowering its efficacy.

3. What is the reason why Tamoxifen causes blood clots?

It modifies estrogen action and influences clotting factors, putting the risk of thromboembolic occurrences.

4. Is it possible to use Tamoxifen to prevent?

Yes, it is applied to high-risk people in order to minimize the risk of getting breast cancer.

5. What is the reason why long-term therapy is necessary?

Due to the fact that continuous estrogen suppression will have to be done to avoid the recurrence of hormone dependent cancer.

Fact Box of Entax 20 (Tamoxifen 20 mg) tablet:

References

• FDA Prescribing Information – Tamoxifen
  https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/017970s068lbl.pdf
• European Medicines Agency (EMA) – Tamoxifen Product Information
  https://www.ema.europa.eu/en/documents/product-information/tamoxifen-epar-product-information_en.pdf
• DrugBank – Tamoxifen
  https://go.drugbank.com/drugs/DB00675
• National Cancer Institute (NCI) – Tamoxifen
  https://www.cancer.gov/about-cancer/treatment/drugs/tamoxifen