Bdenza 40mg (Enzalutamide 40mg) capsule

Description of Bdenza 40mg (Enzalutamide 40mg) capsule 

Bdenza 40mg capsule contains Enzalutamide 40mg are medication formulated to treat prostate cancer. It is considered an androgen receptor inhibitor that helps block the effects of androgens (male hormones) that can promote the growth of cancer cells.

Indications of Bdenza 40mg (Enzalutamide 40mg) capsule 

Bdenza 40mg (Enzalutamide 40mg) capsule is primarily indicated for use in adult men with metastatic castration-resistant prostate cancer. It may also be prescribed for non-metastatic castration-resistant prostate cancer based on individual patient circumstances.

Mechanism of Action of Bdenza 40mg (Enzalutamide 40mg) capsule

Enzalutamide works by inhibiting androgen receptor signaling, which prevents androgens from promoting the growth of prostate cancer cells. This blockade results in decreased cancer cell proliferation and increased cancer cell apoptosis.

How to Consume Bdenza 40mg (Enzalutamide 40mg) capsule

Take the enzalutamide capsules exactly as per the prescribed dose given by healthcare physician. It is typically consumed once daily, with or without food. It is important to swallow the capsules whole and not to open, crush, or chew them.

Side Effects of Bdenza 40mg (Enzalutamide 40mg) capsule

  1. Common Side Effects

– Fatigue

– Hot flashes

– Diarrhea

– Joint pain

– Decreased appetite

2. Serious Side Effects

– Seizures

– Signs of liver problems (such as jaundice)

– Allergic reactions (rash, itching, swelling)

3. Rare Side Effects

– Cardiovascular events (e.g., myocardial infarction)

– Bone fractures

– Changes in mood or behavior

Safety Advice for Bdenza 40mg (Enzalutamide 40mg) capsule

Patients taking Enzalutamide should be monitored for potential side effects, especially neurological effects like seizures. Regular liver function tests may also be recommended.

Alcohol: Alcohol consumption should be limited, as it may increase the risk of certain side effects.

Liver: Patients with liver dysfunction should use Enzalutamide with caution.

Lungs: If there are any existing lung conditions, patients should discuss this with their doctor prior to starting treatment.

Driving: Enzalutamide may cause fatigue and dizziness; caution is advised when driving or operating machinery.

Interaction of Bdenza 40mg (Enzalutamide 40mg) capsule

• Drug-Drug Interaction : 

1. CYP2C8 and CYP3A4 Inhibitors: Medications that inhibit these enzymes can increase the concentration of enzalutamide in the bloodstream. Examples include certain antifungal agents and antibiotics.
2. CYP2C8 and CYP3A4 Inducers: On the other hand, drugs that induce these enzymes can reduce the effectiveness of enzalutamide. Examples include certain anticonvulsants and herbal supplements like St. John’s Wort.
3. Other Antineoplastic Agents: Using enzalutamide alongside other cancer treatments can also lead to increased toxicity or altered efficacy, so careful monitoring is required.
4. Anticoagulants: There may be increased bleeding risks when enzalutamide is used with blood thinners; close observation is necessary.
5. Hormonal Therapies: Other hormonal treatments could potentially interact with enzalutamide, affecting its action.

• Drug-Food Interaction: High-fat meals can increase the absorption of Enzalutamide.
• Drug-Disease Interaction: Enzalutamide should be used cautiously in patients with a history of seizures or liver disorders.

Contraindication of Bdenza 40mg (Enzalutamide 40mg) capsule

Enzalutamide is contraindicated in patients with a known hypersensitivity to the drug or its components. It should also be avoided in women who are pregnant or breastfeeding due to potential harm to the fetus or infant.

Enzalutamide is contraindicated in patients with a history of seizures and in women who are pregnant or breastfeeding. Avoid use with strong CYP2C8 or CYP3A4 inhibitors.

Dosage of Bdenza 40mg (Enzalutamide 40mg) capsule

The typical prescribed dosage is 160 mg orally once daily (four 40 mg capsules). Your healthcare provider may adjust the dosage based on individual tolerance and response to treatment.

Storage of Bdenza 40mg (Enzalutamide 40mg) capsule

Enzalutamide capsules should be stored at room temperature, away from excess heat and moisture. Always keep this medicine in its original pack and away from children.

Missed Dose of Bdenza 40mg (Enzalutamide 40mg) capsule

If you miss a dose, take the next dose as scheduled—do not take two doses at once. Do not double up on doses to make up for a missed one.

Other General Information of Bdenza 40mg (Enzalutamide 40mg) capsule

Bdenza 40mg Capsule causes skin dryness so it is advised to use an effective moisturiser for your skin. Ensure that you stay hydrated and maintain a balanced diet. It is important to attend regular follow-up appointments with your healthcare provider while on Enzalutamide and to report any unusual side effects immediately.

For more detailed information about Enzalutamide and personalized treatment plans, please consult your healthcare provider.

FAQs about Bdenza 40mg (Enzalutamide 40mg) capsule

1. What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember but skip it if it’s almost time for the next dose.

2. Can Enzalutamide be taken with other medications?

Always inform your doctor about all medications you are taking to avoid potential interactions.

3. What should I do in case of an overdose?

In the event of an overdose, contact a physician or go to the nearest emergency department     immediately.

References

• PubChem. Enzalutamide. [Accessed 27 Mar. 2019] (online) Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Enzalutamide
• Enzalutamide. Netherlands: Astellas Pharma Europe B.V.; [Accessed on 27 Mar. 2019] (online) Available from: https://www.ema.europa.eu/en/documents/product-information/xtandi-epar-product-information_en.pdf
• [Internet]. Medlineplus.gov. 2018 [cited 19 December 2018]. Available from: https://medlineplus.gov/druginfo/meds/a612033.html
• [Internet]. Drugbank.ca. 2018 [cited 19 December 2018]. Available from: https://go.drugbank.com/drugs/DB08899