Bosutris 400 Tablet

Description of Bosutris 400 (Bosutinib 400mg) tablet

Bosutinib 400mg is an anticancer therapeutic used in the treatment of particular hematologic cancer. The compound is sold as a tablet by various commercial names such as Bosutris 400. It is a Tyrosine Kinase Inhibitor (TKI) and its antitumor activity is due to selective inhibition of malignant cellular proliferation through the selective blockage of the aberrant protein signaling pathways. As a result, the agent decreases the tumor mass and retards the development of malignant cells.

Indications of Bosutris 400 (Bosutinib 400mg) tablet

Bosutris 400 tablet is used in the treatment of some cancers including Chronic Myeloid Leukaemia (CML), and Acute Lymphoblastic Leukemia (ALL), The drug is widely used in the treatment of patients with these types of malignancies, and it can also be administered in case other forms of treatment are ineffective or unsuitable.

Mechanism of action of Bosutris 400 (Bosutinib 400mg) tablet 

Bosutinib is a Tyrosine Kinase Inhibitor that inhibits the catalytic function of dysregulated kinases like BCR-ABL and Src that play a central role in the dysregulated mitotic activity of leukemic cells. Blockage of these enzymes blocks the passage of proliferation and survival messages to the cancerous cells. The result is a reduction in cellular proliferation, and hence it eases the control and management of diseases.

How to consume of Bosutris 400 (Bosutinib 400mg) tablet

Use of Bosutinib must be in the correct dosing and time as prescribed by a certified medical practitioner. The medicine is usually administered once per day, and it is best using meals and one full glass of water to reduce gastrointestinal irritation. The tablet should also not be crushed or chewed nor broken unless such a directive is given by the prescribing physician.

Side Effects of Bosutris 400 (Bosutinib 400mg) tablet

1. Common side effects

• Feeling tired
• Nausea or vomiting
• Problems with diarrhea
• Mild swelling in hands or feet
• Appetite gets lower

2. Serious side effects

• Chest pain, arrhythmia
• Abnormalities of hepatic functioning
• Severe anemia or major decrease of the peripheral blood cell counts
• Severe bleeding

3. Rare side effects

• Irregular heart rhythmical conduction
• Muscle spasm
• Severe stomach pain

Safety Advice for Bosutris 400 (Bosutinib 400mg) tablet

Individuals who are under Bosutinib must be subjected to regular medical care comprising of complete blood counts, hepatic panel, kidney tests, and fluid status. The treating physician recommends serial laboratory assessments on a regular basis.

Breastfeeding: Bosutinib should not be administered during lactation and this agent may leak through the breast milk and be harmful to the baby. The decision should be approved by consulting a healthcare expert.

Pregnancy: During pregnancy, Bosutinib should also be avoided because it is teratogenic. Reproductive potential women are expected to use good birth control and consult medical help prior to the initiation.

Alcohol: The use of alcohol should be reduced or avoided because alcohol can increase hepatic-related adverse events.

Liver: The Bosutinib should be used with great caution in people who already have a hepatic impairment under strict physician supervision.

Lungs: Patients who have a history of lung disorders are expected to report the same to their clinician before commencing treatment.

Kidney: Patients who have renal insufficiency should exercise caution, and changes in the dosage can be required.

Driving: Sometimes the drug can also cause dizziness or blurring of sight. When such symptoms manifest, patients are advised not to drive or do heavy machinery.

Interaction of Bosutris 400 (Bosutinib 400mg) tablet

• Drug-Drug Interaction :

Lefamulin x Bosutinib

It is contraindicated to use this medicine because the use of bosutinib affect the effect of heaptic enzyme metabolism.

Famotidine x Bosutinib

Use alternative drug because the use of famotidine will decrease the effect of bosutinib by increasing its gastric pH.

Atorvastatin x Bosutinib

Use alternative drug because the use of atorvastatin will increase the effect of Bosutinib by P-glycoprotein efflux transporter.

Chlorpromazine x Bosutinib

Therapy should be administered with caution because the combination of this medicine increases the QTc interval.

Dichlorphenamide x Bosutinib

Therapy should be administered with caution because the combination of this medicine may decrease the serum potassium level.

• Drug-Food Interaction:

Food:

Do not take grapefruit while you are receiving this medicine because grapefruit may increase the blood levels which leads to slow heart rate. Kindly contact doctor if you have experience dizziness, lightheadedness, shortness of breath, bleeding, weight loss, chills, and diarrhea.

• Drug-Disease Interaction:

Cardiovascular disease:

There should be caution in the administration of this therapeutic agent and its administration has been linked to arterial and peripheral vascular occlusive events, and ischemic cerebrovascular incidents.

Fluid retention:

Therapy should be administered with caution in patients with congestive heart failure because the use of this medicine may cause pericardial effusion, pleural effusion, pulmonary edema and peripheral edema.

Bone marrow suppression:

Pharmacologic exposure to this agent in persons with a history of bone marrow suppression will cause thrombocytopenia, aplastic anemia, agranulocytosis, and neutropenia and thus therapeutic intervention should be done cautiously. Pulmonary arterial hypertension: The use of this agent has been linked to a high incidence of developing pulmonary arterial hypertension and this may occur through symptoms that include dyspnea, fatigue, hypoxia and retention of fluid.

Pulmonary arterial hypertension:

The clinical information suggests that the exposure to its agent is associated with an increased risk of pulmonary arterial hypertension that has such symptoms as dyspnea, fatigue, hypoxia, and fluid retention.

Contraindication of Bosutris 400 (Bosutinib 400mg) tablet

It is contraindicated to use this medicine in patients with hepatic impairment.

The use of this medicine is cautious in patients who are having history of diarrhea, vomiting, anemia.

Dosage of Bosutris 400 (Bosutinib 400mg) tablet

Dose depends on the type of cancer. The doctor may make changes depending upon personal tolerance and how the treatment is working.

Storage of Bosutris 400 (Bosutinib 400mg) tablet

Tablets of Bosutinib need to be kept somewhere with average room temperature conditions, protecting it from too much moisture or heat. You should always have them inside packet they are in and out of reach of children.

Missed Dose of Bosutris 400 (Bosutinib 400mg) tablet

If you miss one tablet, just use planned next dose on the regular schedule. Taking two tablets together to replace a missed one is not required. Do not try to increase your next dose for this.

Other General Information of Bosutris 400 (Bosutinib 400mg) tablet 

The use of Bosutris 400 tablet might create dry skin, so using proper moisturizer is recommended by the doctors. Stay hydrated by drinking water and eat with more balanced as much as you can. Attending frequent checkups with doctor is important during treatment; you should notify any strange side effects as soon as possible. If you want further instructions or details for your case, contact your doctor.

FAQs of Bosutris 400 (Bosutinib 400mg) tablet 

1. What can be done in case one feels significantly tired or slightly dizzy?

Patients who have a severe level of fatigue or vertigo must inform their doctor immediately, and the specialist will subsequently alter the dosage.

2. Can Bosutinib be administered together with other drugs?

All concomitant medications should be reported to the prescribing doctor to enable the prescribing physician to know about the possibilities of drug-drug interactions and avert the issues.

3. What should be the duration of Bosutinib?

Patients are expected to take Bosutinib as per their dose and period as given by their clinician. Acute withdrawal can trigger harmful consequences.

4. Is it possible to concomitant Bosutinib with other medicine?

You should tell your doctor about the history of your medication on consultation given that there are drugs that can amplify the side effects.

5. Does Bosutinib have an impact on fertility?

No, the prescription of this drug can lower the fertility rates of both men and women. Please also advise your physician in case you are going to have a baby.

Fact Box of Bosutris 400 (Bosutinib 400mg) tablet:

Field	Details
Generic/Molecule Name	Bosutinib
Therapeutic Class	Anti-neoplastic agent
Pharmacological Class	Tyrosine kinase inhibitor
Dosage form	tablet
Habit forming	No
Indication	Blood cancer

 

References

• Bosutinib [FDA Label]. New York, NY: Pfizer Labs; 2017. [Accessed 18 Dec. 2020] (online) Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/20334s007s008lbl.pdf
• Bosutinib [FDA Label]. Silver Spring, MD: U.S. Food and Drug Administration; 2023. [Accessed 12 Feb 2026]. (Online) Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/203341s0xxlbl.pdf
• Bosulif (Bosutinib) Summary of Product Characteristics. New York, NY: Pfizer Labs; 2022. [Accessed 12 Feb 2026]. (Online) Available from: https://labeling.pfizer.com/ShowLabeling.aspx?id=884
• Bosutinib – Drug Information. National Center for Biotechnology Information (NCBI). [Accessed 12 Feb 2026]. (Online) Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Bosutinib