Vilban 10 Injection

Description of Vilban 10 (Vinblastine 10 mg) injection

Vinblastine, a part of Vilban 10 injection, is a type of antineoplastic drug, a member of vinca alkaloids. It is a derivative of periwinkle plant and is commonly used in treating different cancers particularly lymphomas and solid tumors. Vinblastine interferes with cell division by disrupting the formation of microtubules which play a crucial role in cell division. It prevents cancer cells by blocking the formation of mitotic spindles, and causes cell death. Vinblastine has greater bone marrow suppression than Vincristine, and less neurotoxicity.

Indications of Vilban 10 (Vinblastine 10 mg) injection

Vinblastine is administered in the management of Hodgkin lymphoma, non-Hodgkin lymphoma, testicular cancer, breast cancer and Kaposi sarcoma. It is used mostly in combination chemotherapy.

Mechanism of action of Vilban 10 (Vinblastine 10 mg) injection

The tubulin binds with vinblastine and prevents the formation of microtubules, which are needed in forming mitotic spindle. This interferes with the separation of the chromosomes during mitosis and blocks the cell cycle in the M-phase eventually causing cell death.

How to consume Vilban 10 (Vinblastine 10 mg) injection

Vinblastine is intravenous and has to be administered under strict medical supervision. Never should it be intrathecally because this could be fatal. It is administered in cycles with a dosage that is dependent on body surface area and is combined with other therapies.

Side Effects of Vilban 10 (Vinblastine 10 mg) injection

1.Common side effects

• Nausea
• Vomiting
• Fatigue
• Hair Loss
• Loss Of Appetite

2. Serious side effects

• Bone Marrow Suppression
• Severe Infections
• Anemia
• Leukopenia

3. Rare side effects

• Neurotoxicity
• Hypersensitivity Reactions

Safety Advice for Vilban 10 (Vinblastine 10 mg) injection

Vinblastine is normally used in the treatment of cancer and its use should be closely supervised by conducting regular blood counts since the drug usually leads to suppression of the bone marrow. Such initial signs of infection like fever should be reported at once.

Breastfeeding: Vinblastine is contraindicated during breast feeding since it can be transferred to breast milk and cause adverse effects to the baby.

Pregnancy: Contraindicated because it may cause damage to the fetus.

Alcohol: Alcohol is not permitted, since it can cause liver stress, and aggravate side effects.

Liver: Vinblastine is hepatically metabolized and thus patients with liver dysfunction must be adjusted in dosage and monitored closely.

Lungs: Any symptoms such as breathlessness should be reported, although pulmonary toxicity is rare.

Kidney: Renal surveillance is recommended, but kidney involvement is not so important.

Driving: Fatigue or weakness may be experienced by patients and therefore driving should be avoided in case of symptoms.

Interaction of Vilban 10 (Vinblastine 10 mg) injection

• Drug–Drug Interaction

Ketoconazole × Vinblastine
These medications suppress Metabolism of Vinblastine and cause high levels of drug and toxicity.

Erythromycin × Vinblastine

May raise the concentration of drugs and danger of side effects.

Others myelosuppressives drugs × Vinblastine.

May predisposes to serious bone marrow depression.

Phenytoin × Vinblastine

May lower the levels of phenytoin and reduce the level of seizure control.

Live vaccines × Vinblastine

It should not be used as it exposes one to greater chances of infection.

• Drug–Food Interaction

Vinblastine is not greatly influenced by food as it is intravenously administered. Grapefruit juice is also to be avoided since it can raise the drug levels by acting on liver enzymes.

• Drug–Disease Interaction of Vilban 10 (Vinblastine 10 mg) injection

Bone marrow disorders:

Vinblastine may have a great impact on bone marrow, causing anemia, infections, and bleeding.

Liver disease:

Liver function can be impaired and consequently produce a higher level of drug and toxicity because of the decreased metabolism.

Infections:

Immunosuppression can contribute to the worsening of patients who have active infections.

Gastrointestinal disorders:

May aggravates nausea and vomiting.

Contraindication of Vilban 10 (Vinblastine 10 mg) injection

Should not be used in hypersensitivity, extreme bone marrow suppression, and intrathecal use.

Dosage of Vilban 10 (Vinblastine 10 mg) injection

It is a dosage that depends on the body surface area and is given intravenously in cycles as a combination therapy. Dose should be adjusted according to blood counts and tolerance of the patient.

Storage of Vilban 10 (Vinblastine 10 mg) injection

Keep in recommended conditions and not exposed to light or heat and not accessible to children.

Missed Dose of Vilban 10 (Vinblastine 10 mg) injection

Keep in recommended conditions and not exposed to light or heat and not accessible to children.

Other General Information of Vilban 10 (Vinblastine 10 mg) injection

Follow-up visits to monitor blood are required of the patients. Reporting of any symptoms like fever, unusual bleeding or extreme weakness should be prompt.

FAQs of Vilban 10 (Vinblastine 10 mg) injection

1.What is the main toxicity of Vinblastine?

The most severe toxicity of this drug is bone marrow suppression.

2.What is the difference between Vinblastine and Vincristine?

Vinblastine induces greater bone marrow suppression but less neurotoxicity than that of Vincristine.

3.Why not be administered intrathecally?

Toxicity can be fatal in case of intrathecal administration.

4.Does Vinblastine augment infection risk?

Yes, because of decreased white blood cell count.

5.What is the purpose of monitoring the blood?

To monitor bone marrow suppression in its early stages and avoid complications.

 Fact Box of Vilban 10 (Vinblastine 10 mg) injection

References

• FDA Prescribing Information – Vinblastine
  https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/009314s041lbl.pdf
• European Medicines Agency (EMA) – Vinblastine Product Information
  https://www.ema.europa.eu/en/documents/product-information/vinblastine-epar-product-information_en.pdf
• DrugBank – Vinblastine
  https://go.drugbank.com/drugs/DB00570
• National Cancer Institute (NCI) – Vinblastine
  https://www.cancer.gov/about-cancer/treatment/drugs/vinblastine